ID   TPPC2_PIG               Reviewed;         140 AA.
AC   F1SRI0;
DT   21-SEP-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 2.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Trafficking protein particle complex subunit 2;
GN   Name=TRAPPC2;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15679890; DOI=10.1186/1741-7007-3-2;
RA   Jorgensen F.G., Hobolth A., Hornshoj H., Bendixen C., Fredholm M.,
RA   Schierup M.H.;
RT   "Comparative analysis of protein coding sequences from human, mouse and the
RT   domesticated pig.";
RL   BMC Biol. 3:2-2(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=14681463; DOI=10.1093/nar/gkh037;
RA   Uenishi H., Eguchi T., Suzuki K., Sawazaki T., Toki D., Shinkai H.,
RA   Okumura N., Hamasima N., Awata T.;
RT   "PEDE (Pig EST Data Explorer): construction of a database for ESTs derived
RT   from porcine full-length cDNA libraries.";
RL   Nucleic Acids Res. 32:D484-D488(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Prevents ENO1-mediated transcriptional repression and
CC       antagonizes ENO1-mediated cell death. May play a role in vesicular
CC       transport from endoplasmic reticulum to Golgi (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Part of the multisubunit TRAPP (transport protein particle)
CC       complex. Interacts with ENO1, PITX1, SF1, TRAPPC2L and TRAPPC3.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC       {ECO:0000250|UniProtKB:P0DI81}. Nucleus {ECO:0000250|UniProtKB:P0DI81}.
CC       Endoplasmic reticulum-Golgi intermediate compartment
CC       {ECO:0000250|UniProtKB:P0DI81}. Cytoplasm
CC       {ECO:0000250|UniProtKB:P0DI81}. Note=Localized in perinuclear granular
CC       structures. {ECO:0000250|UniProtKB:P0DI81}.
CC   -!- SIMILARITY: Belongs to the TRAPP small subunits family. Sedlin
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AY610478; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AK344004; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; CU633939; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001231738.1; NM_001244809.1.
DR   AlphaFoldDB; F1SRI0; -.
DR   SMR; F1SRI0; -.
DR   STRING; 9823.ENSSSCP00000012907; -.
DR   PaxDb; F1SRI0; -.
DR   PeptideAtlas; F1SRI0; -.
DR   Ensembl; ENSSSCT00005028002; ENSSSCP00005017070; ENSSSCG00005017658.
DR   Ensembl; ENSSSCT00055038261; ENSSSCP00055030396; ENSSSCG00055019457.
DR   Ensembl; ENSSSCT00070037883; ENSSSCP00070031684; ENSSSCG00070019186.
DR   GeneID; 100513447; -.
DR   KEGG; ssc:100513447; -.
DR   CTD; 6399; -.
DR   eggNOG; KOG3487; Eukaryota.
DR   HOGENOM; CLU_085828_0_2_1; -.
DR   InParanoid; F1SRI0; -.
DR   OMA; VDKFNQW; -.
DR   OrthoDB; 1426075at2759; -.
DR   Reactome; R-SSC-204005; COPII-mediated vesicle transport.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unassembled WGS sequence.
DR   Genevisible; F1SRI0; SS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0030008; C:TRAPP complex; IBA:GO_Central.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   InterPro; IPR006722; Sedlin.
DR   PANTHER; PTHR12403; PTHR12403; 1.
DR   Pfam; PF04628; Sedlin_N; 1.
DR   SUPFAM; SSF64356; SSF64356; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; ER-Golgi transport; Nucleus; Reference proteome; Transcription;
KW   Transport.
FT   CHAIN           1..140
FT                   /note="Trafficking protein particle complex subunit 2"
FT                   /id="PRO_0000412462"
SQ   SEQUENCE   140 AA;  16415 MW;  9EF9942B64E527DD CRC64;
     MSGSFYFVIV GHHDNPVFEM EFLPAGKAES KDDHRHLNQF IAHAALDLVD ENMWLSNNMY
     LKTVDKFNEW FVSAFVTAGH MRFIMLHDVR QEDGIKNFFT DVYDLYIKFA MNPFYEPNSP
     IRSSAFDRKV QFLGKKHLLS