ID   TPPC2_PONAB             Reviewed;         140 AA.
AC   Q5RES6;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Trafficking protein particle complex subunit 2;
GN   Name=TRAPPC2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Prevents ENO1-mediated transcriptional repression and
CC       antagonizes ENO1-mediated cell death. May play a role in vesicular
CC       transport from endoplasmic reticulum to Golgi (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Part of the multisubunit TRAPP (transport protein particle)
CC       complex. Interacts with ENO1, PITX1, SF1, TRAPPC2L and TRAPPC3.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region
CC       {ECO:0000250|UniProtKB:P0DI81}. Nucleus {ECO:0000250|UniProtKB:P0DI81}.
CC       Endoplasmic reticulum-Golgi intermediate compartment
CC       {ECO:0000250|UniProtKB:P0DI81}. Cytoplasm
CC       {ECO:0000250|UniProtKB:P0DI81}. Note=Localized in perinuclear granular
CC       structures. {ECO:0000250|UniProtKB:P0DI81}.
CC   -!- SIMILARITY: Belongs to the TRAPP small subunits family. Sedlin
CC       subfamily. {ECO:0000305}.
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DR   EMBL; CR857440; CAH89731.1; -; mRNA.
DR   RefSeq; NP_001124790.1; NM_001131318.2.
DR   AlphaFoldDB; Q5RES6; -.
DR   SMR; Q5RES6; -.
DR   STRING; 9601.ENSPPYP00000011724; -.
DR   Ensembl; ENSPPYT00000012170; ENSPPYP00000011724; ENSPPYG00000010463.
DR   GeneID; 100171643; -.
DR   KEGG; pon:100171643; -.
DR   CTD; 6399; -.
DR   eggNOG; KOG3487; Eukaryota.
DR   GeneTree; ENSGT00510000047168; -.
DR   HOGENOM; CLU_085828_3_0_1; -.
DR   InParanoid; Q5RES6; -.
DR   Proteomes; UP000001595; Chromosome 19.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0005793; C:endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell.
DR   GO; GO:0005640; C:nuclear outer membrane; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0001222; F:transcription corepressor binding; IEA:Ensembl.
DR   GO; GO:0140416; F:transcription regulator inhibitor activity; IEA:Ensembl.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:InterPro.
DR   GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   InterPro; IPR006722; Sedlin.
DR   PANTHER; PTHR12403; PTHR12403; 1.
DR   Pfam; PF04628; Sedlin_N; 1.
DR   SUPFAM; SSF64356; SSF64356; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; ER-Golgi transport; Nucleus; Reference proteome; Transcription;
KW   Transport.
FT   CHAIN           1..140
FT                   /note="Trafficking protein particle complex subunit 2"
FT                   /id="PRO_0000260209"
SQ   SEQUENCE   140 AA;  16431 MW;  B099942B64E534FC CRC64;
     MSGSFYFVIV GHHDNPVFEM EFLPAGKAES KDDHRHLNQF IAHAALDLVD ENMWLSNNMY
     LKTVDKFNEW FVSAFVTAGH MRFIMLHDVR QEDGIKNFFT DVYDLYIKFS MNPFYEPNSP
     IRSSAFDRKV QFLGKKHLLS