ID   TPPC3_CAEEL             Reviewed;         181 AA.
AC   P34605;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 153.
DE   RecName: Full=Trafficking protein particle complex subunit 3 homolog {ECO:0000250|UniProtKB:O43617};
GN   Name=trpp-3; ORFNames=ZK1098.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   FUNCTION.
RX   PubMed=16862146; DOI=10.1038/ncbl439;
RA   Saleh M.-C., van Rij R.P., Hekele A., Gillis A., Foley E., O'Farrell P.H.,
RA   Andino R.;
RT   "The endocytic pathway mediates cell entry of dsRNA to induce RNAi
RT   silencing.";
RL   Nat. Cell Biol. 8:793-802(2006).
CC   -!- FUNCTION: May play a role in vesicular transport from endoplasmic
CC       reticulum to Golgi (By similarity). Required for the systemic spread of
CC       the RNAi response (PubMed:16862146). {ECO:0000250|UniProtKB:O43617,
CC       ECO:0000269|PubMed:16862146}.
CC   -!- SUBUNIT: Homodimer. Part of the multisubunit TRAPP (transport protein
CC       particle) complex (By similarity). {ECO:0000250|UniProtKB:O43617}.
CC   -!- INTERACTION:
CC       P34605; Q9U389: allo-1; NbExp=2; IntAct=EBI-312149, EBI-312154;
CC       P34605; Q20100: trpp-4; NbExp=6; IntAct=EBI-312149, EBI-321262;
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network
CC       {ECO:0000250|UniProtKB:Q04183}. Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q9CQP2}.
CC   -!- SIMILARITY: Belongs to the TRAPP small subunits family. BET3 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; Z22176; CAA80133.1; -; Genomic_DNA.
DR   PIR; S40928; S40928.
DR   RefSeq; NP_499100.1; NM_066699.4.
DR   AlphaFoldDB; P34605; -.
DR   SMR; P34605; -.
DR   BioGRID; 41539; 8.
DR   DIP; DIP-25615N; -.
DR   IntAct; P34605; 7.
DR   STRING; 6239.ZK1098.5; -.
DR   EPD; P34605; -.
DR   PaxDb; P34605; -.
DR   PeptideAtlas; P34605; -.
DR   EnsemblMetazoa; ZK1098.5.1; ZK1098.5.1; WBGene00014222.
DR   GeneID; 176344; -.
DR   KEGG; cel:CELE_ZK1098.5; -.
DR   UCSC; ZK1098.5; c. elegans.
DR   CTD; 176344; -.
DR   WormBase; ZK1098.5; CE00368; WBGene00014222; trpp-3.
DR   eggNOG; KOG3330; Eukaryota.
DR   GeneTree; ENSGT00390000003880; -.
DR   HOGENOM; CLU_087110_0_0_1; -.
DR   InParanoid; P34605; -.
DR   OMA; WTSDNKQ; -.
DR   OrthoDB; 1334804at2759; -.
DR   PhylomeDB; P34605; -.
DR   Reactome; R-CEL-204005; COPII-mediated vesicle transport.
DR   Reactome; R-CEL-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR   PRO; PR:P34605; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00014222; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0033106; C:cis-Golgi network membrane; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0030008; C:TRAPP complex; IBA:GO_Central.
DR   GO; GO:0042338; P:cuticle development involved in collagen and cuticulin-based cuticle molting cycle; IMP:WormBase.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0035264; P:multicellular organism growth; IMP:WormBase.
DR   GO; GO:0009306; P:protein secretion; IMP:WormBase.
DR   CDD; cd14942; TRAPPC3_bet3; 1.
DR   InterPro; IPR016721; Bet3.
DR   InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR   InterPro; IPR007194; TRAPP_component.
DR   PANTHER; PTHR13048; PTHR13048; 1.
DR   Pfam; PF04051; TRAPP; 1.
DR   PIRSF; PIRSF018293; TRAPP_I_complex_Bet3; 1.
DR   SUPFAM; SSF111126; SSF111126; 1.
PE   1: Evidence at protein level;
KW   Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Lipoprotein;
KW   Palmitate; Reference proteome; Transport.
FT   CHAIN           1..181
FT                   /note="Trafficking protein particle complex subunit 3
FT                   homolog"
FT                   /id="PRO_0000211577"
FT   LIPID           70
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250|UniProtKB:O43617"
SQ   SEQUENCE   181 AA;  19699 MW;  58340B5911AEDB3C CRC64;
     MSKAIKQNLA DSKKMSAELF CLTYGAMVTE MLKDYEDPKD VTIQLDKMGF NMGTRLADDF
     LAKNANVPRC VDTRQIADVL CRNAIPCYLG ISATASSWTS GDREFTITLE ANPLTELVQV
     PAHLVSAGLS YSQLIAGAIR GALEAVHFKV YASATDTGAN TEIRIRFDQV LKDSLPAGED
     D