ID   TPPC3_DICDI             Reviewed;         186 AA.
AC   Q86K94; Q550D8;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JAN-2010, sequence version 2.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Trafficking protein particle complex subunit 3;
GN   Name=trappc3; ORFNames=DDB_G0277135;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: May play a role in vesicular transport from endoplasmic
CC       reticulum to Golgi. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Part of the multisubunit TRAPP (transport protein
CC       particle) complex (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}.
CC       Endoplasmic reticulum {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAPP small subunits family. BET3 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000019; EAL68879.3; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_642804.3; XM_637712.3.
DR   AlphaFoldDB; Q86K94; -.
DR   SMR; Q86K94; -.
DR   STRING; 44689.DDB0252667; -.
DR   PaxDb; Q86K94; -.
DR   EnsemblProtists; EAL68879; EAL68879; DDB_G0277135.
DR   GeneID; 8620867; -.
DR   KEGG; ddi:DDB_G0277135; -.
DR   dictyBase; DDB_G0277135; trappc3.
DR   eggNOG; KOG3330; Eukaryota.
DR   HOGENOM; CLU_087110_0_0_1; -.
DR   InParanoid; Q86K94; -.
DR   OMA; WTSDNKQ; -.
DR   PhylomeDB; Q86K94; -.
DR   Reactome; R-DDI-204005; COPII-mediated vesicle transport.
DR   Reactome; R-DDI-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR   PRO; PR:Q86K94; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0033106; C:cis-Golgi network membrane; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0030008; C:TRAPP complex; IBA:GO_Central.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:dictyBase.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR   CDD; cd14942; TRAPPC3_bet3; 1.
DR   InterPro; IPR016721; Bet3.
DR   InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR   InterPro; IPR007194; TRAPP_component.
DR   PANTHER; PTHR13048; PTHR13048; 1.
DR   Pfam; PF04051; TRAPP; 1.
DR   PIRSF; PIRSF018293; TRAPP_I_complex_Bet3; 1.
DR   SUPFAM; SSF111126; SSF111126; 1.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW   Reference proteome; Transport.
FT   CHAIN           1..186
FT                   /note="Trafficking protein particle complex subunit 3"
FT                   /id="PRO_0000330747"
SQ   SEQUENCE   186 AA;  21211 MW;  4AA937467803BC72 CRC64;
     MSKKYDKLGN DVFNKVEKIN SELFTLTYGA LVTQLIKDYE DIEQVNIKLE QMGYNIGIRL
     IEEFLAKSGI GRCSDFIETA EVIAKVGFKM FLGVNAHVGD WDANRKEFHL TIEDNPLIDF
     VELPDQYKHK LYYSNILCGV MRGALEMVQM KVKCTFVKCT LSDDSTSEIK VVLEEVLSDM
     IPVGYD