ID   TPPC3_RAT               Reviewed;         180 AA.
AC   Q5U1Z2;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Trafficking protein particle complex subunit 3;
GN   Name=Trappc3 {ECO:0000312|RGD:1309135};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in vesicular transport from endoplasmic
CC       reticulum to Golgi. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Component of the multisubunit transport protein
CC       particle (TRAPP) complex, which includes at least TRAPPC2, TRAPPC2L,
CC       TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10,
CC       TRAPPC11 and TRAPPC12. Heterodimer with TRAPPC6A. The heterodimer
CC       TRAPPC3-TRAPPC6A interacts with TRAPPC2L. Heterodimer with TRAPPC6b.
CC       The heterodimer TRAPPC6B-TRAPPC3 interacts with TRAPPC1 likely
CC       providing a core for TRAPP complex formation.
CC       {ECO:0000250|UniProtKB:O43617}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}.
CC       Endoplasmic reticulum {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAPP small subunits family. BET3 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; BC086377; AAH86377.1; -; mRNA.
DR   RefSeq; NP_001008377.1; NM_001008376.1.
DR   AlphaFoldDB; Q5U1Z2; -.
DR   SMR; Q5U1Z2; -.
DR   BioGRID; 263569; 2.
DR   IntAct; Q5U1Z2; 2.
DR   MINT; Q5U1Z2; -.
DR   STRING; 10116.ENSRNOP00000014383; -.
DR   SwissPalm; Q5U1Z2; -.
DR   jPOST; Q5U1Z2; -.
DR   PaxDb; Q5U1Z2; -.
DR   PRIDE; Q5U1Z2; -.
DR   GeneID; 362599; -.
DR   KEGG; rno:362599; -.
DR   UCSC; RGD:1309135; rat.
DR   CTD; 27095; -.
DR   RGD; 1309135; Trappc3.
DR   VEuPathDB; HostDB:ENSRNOG00000010550; -.
DR   eggNOG; KOG3330; Eukaryota.
DR   HOGENOM; CLU_087110_0_0_1; -.
DR   InParanoid; Q5U1Z2; -.
DR   OMA; WTSDNKQ; -.
DR   OrthoDB; 1334804at2759; -.
DR   PhylomeDB; Q5U1Z2; -.
DR   TreeFam; TF300091; -.
DR   Reactome; R-RNO-204005; COPII-mediated vesicle transport.
DR   Reactome; R-RNO-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR   PRO; PR:Q5U1Z2; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000010550; Expressed in cerebellum and 20 other tissues.
DR   Genevisible; Q5U1Z2; RN.
DR   GO; GO:0033106; C:cis-Golgi network membrane; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; ISO:RGD.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; ISO:RGD.
DR   GO; GO:0030008; C:TRAPP complex; ISO:RGD.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISO:RGD.
DR   GO; GO:0006891; P:intra-Golgi vesicle-mediated transport; IBA:GO_Central.
DR   CDD; cd14942; TRAPPC3_bet3; 1.
DR   InterPro; IPR016721; Bet3.
DR   InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR   InterPro; IPR007194; TRAPP_component.
DR   PANTHER; PTHR13048; PTHR13048; 1.
DR   Pfam; PF04051; TRAPP; 1.
DR   PIRSF; PIRSF018293; TRAPP_I_complex_Bet3; 1.
DR   SUPFAM; SSF111126; SSF111126; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Lipoprotein;
KW   Palmitate; Reference proteome; Transport.
FT   CHAIN           1..180
FT                   /note="Trafficking protein particle complex subunit 3"
FT                   /id="PRO_0000211574"
FT   LIPID           68
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   180 AA;  20302 MW;  B8D57A33D68C0D94 CRC64;
     MSRQANRGTE SKKMSSELFT LTYGALVTQL CKDYENDEDV NKQLDRMGYN IGVRLIEDFL
     ARSNVGRCHD FRETADVIAK VAFKMYLGIT PSITNWSPAG DEFSLILENN PLVDFVELPD
     NHSALIYSNL LCGVLRGALE MVQMAVEAKF VQDTLKGDGV TEIRMRFIRR IEDNLPAGEE