ID   TPPC4_BOVIN             Reviewed;         219 AA.
AC   Q2TBL9;
DT   28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Trafficking protein particle complex subunit 4;
GN   Name=TRAPPC4;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Core component of the TRAPP complexes which has a function of
CC       guanine nucleotide exchange factor activity for Rab1 GTPase. Plays a
CC       role in vesicular transport from endoplasmic reticulum to Golgi and
CC       autophagy (By similarity). May play a role in dendrite postsynaptic
CC       membrane trafficking (By similarity). {ECO:0000250|UniProtKB:Q9ES56,
CC       ECO:0000250|UniProtKB:Q9Y296}.
CC   -!- SUBUNIT: Component of the multisubunit TRAPP (transport protein
CC       particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3,
CC       TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and
CC       TRAPPC12 (By similarity). Interacts with SDC2 (By similarity).
CC       {ECO:0000250|UniProtKB:Q9ES56, ECO:0000250|UniProtKB:Q9Y296}.
CC   -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane
CC       {ECO:0000250|UniProtKB:Q9ES56}. Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q9ES56}. Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q9ES56}. Vesicle {ECO:0000250|UniProtKB:Q9ES56}.
CC       Note=Associated with postsynaptic membranes and in intracellular
CC       cisterns and vesicles (Golgi). {ECO:0000250|UniProtKB:Q9ES56}.
CC   -!- SIMILARITY: Belongs to the TRAPP small subunits family. TRAPPC4
CC       subfamily. {ECO:0000305}.
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DR   EMBL; BC109939; AAI09940.1; -; mRNA.
DR   RefSeq; NP_001033591.1; NM_001038502.2.
DR   RefSeq; NP_001178133.1; NM_001191204.1.
DR   AlphaFoldDB; Q2TBL9; -.
DR   SMR; Q2TBL9; -.
DR   STRING; 9913.ENSBTAP00000010619; -.
DR   PaxDb; Q2TBL9; -.
DR   PRIDE; Q2TBL9; -.
DR   Ensembl; ENSBTAT00000010619; ENSBTAP00000010619; ENSBTAG00000008075.
DR   GeneID; 785345; -.
DR   KEGG; bta:785345; -.
DR   CTD; 51399; -.
DR   VEuPathDB; HostDB:ENSBTAG00000008075; -.
DR   VGNC; VGNC:36290; TRAPPC4.
DR   eggNOG; KOG3369; Eukaryota.
DR   GeneTree; ENSGT00940000153761; -.
DR   HOGENOM; CLU_053380_1_0_1; -.
DR   InParanoid; Q2TBL9; -.
DR   OMA; GQRDGIN; -.
DR   OrthoDB; 1504863at2759; -.
DR   TreeFam; TF314561; -.
DR   Reactome; R-BTA-204005; COPII-mediated vesicle transport.
DR   Reactome; R-BTA-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR   Proteomes; UP000009136; Chromosome 15.
DR   Bgee; ENSBTAG00000008075; Expressed in pituitary gland and 107 other tissues.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005795; C:Golgi stack; IEA:Ensembl.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008021; C:synaptic vesicle; IEA:Ensembl.
DR   GO; GO:0030008; C:TRAPP complex; ISS:UniProtKB.
DR   GO; GO:0006914; P:autophagy; ISS:UniProtKB.
DR   GO; GO:0016358; P:dendrite development; IEA:Ensembl.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   InterPro; IPR007233; TRAPPC.
DR   PANTHER; PTHR23249; PTHR23249; 1.
DR   Pfam; PF04099; Sybindin; 1.
DR   SMART; SM01399; Sybindin; 1.
DR   SUPFAM; SSF64356; SSF64356; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW   Membrane; Postsynaptic cell membrane; Reference proteome; Synapse;
KW   Transport.
FT   CHAIN           1..219
FT                   /note="Trafficking protein particle complex subunit 4"
FT                   /id="PRO_0000260210"
SQ   SEQUENCE   219 AA;  24264 MW;  CF74CB56A12D1793 CRC64;
     MAIFSVYVVN KAGGLIYQLD SYAPRAEAEK TFSYPLDLLL KLHDERVLVA FGQRDGIRVG
     HAVLAINGVD VNGKYTADGK EVLEYLGNPA NYPVSIRFGR PRLTSNEKLM LASMFHSLFA
     IGSQLSPEQG SSGIEMLETD TFKLHCFQTL TGIKFVVLAD PRQAGIDSLL RKIYEIYSDF
     ALKNPFYSLE MPIRCELFDQ NLKLALEVAE KAGTFGPGS