ID   TPPC4_RAT               Reviewed;         219 AA.
AC   Q69BT7; Q4G098;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Trafficking protein particle complex subunit 4 {ECO:0000305};
DE   AltName: Full=Synbindin {ECO:0000250|UniProtKB:Q9ES56};
GN   Name=Trappc4 {ECO:0000312|RGD:1302991};
GN   Synonyms=Sbdn {ECO:0000250|UniProtKB:Q9ES56};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Wistar;
RA   Karasawa T., Koike H., Han G.D., Miyauchi N., Harita Y., Suzuki K.,
RA   Shimizu F., Kawachi H.;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Core component of the TRAPP complexes which has a function of
CC       guanine nucleotide exchange factor activity for Rab1 GTPase. Plays a
CC       role in vesicular transport from endoplasmic reticulum to Golgi and
CC       autophagy (By similarity). May play a role in dendrite postsynaptic
CC       membrane trafficking (By similarity). {ECO:0000250|UniProtKB:Q9ES56,
CC       ECO:0000250|UniProtKB:Q9Y296}.
CC   -!- SUBUNIT: Component of the multisubunit TRAPP (transport protein
CC       particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3,
CC       TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and
CC       TRAPPC12 (By similarity). Interacts with SDC2 (By similarity).
CC       {ECO:0000250|UniProtKB:Q9ES56, ECO:0000250|UniProtKB:Q9Y296}.
CC   -!- SUBCELLULAR LOCATION: Postsynaptic cell membrane
CC       {ECO:0000250|UniProtKB:Q9ES56}. Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q9ES56}. Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q9ES56}. Vesicle {ECO:0000250|UniProtKB:Q9ES56}.
CC       Note=Associated with postsynaptic membranes and in intracellular
CC       cisterns and vesicles (Golgi). {ECO:0000250|UniProtKB:Q9ES56}.
CC   -!- SIMILARITY: Belongs to the TRAPP small subunits family. TRAPPC4
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AY373378; AAR19042.1; -; mRNA.
DR   EMBL; BC098628; AAH98628.1; -; mRNA.
DR   RefSeq; NP_001003708.1; NM_001003708.1.
DR   AlphaFoldDB; Q69BT7; -.
DR   SMR; Q69BT7; -.
DR   STRING; 10116.ENSRNOP00000016145; -.
DR   PhosphoSitePlus; Q69BT7; -.
DR   jPOST; Q69BT7; -.
DR   PaxDb; Q69BT7; -.
DR   PRIDE; Q69BT7; -.
DR   GeneID; 367073; -.
DR   KEGG; rno:367073; -.
DR   UCSC; RGD:1302991; rat.
DR   CTD; 51399; -.
DR   RGD; 1302991; Trappc4.
DR   eggNOG; KOG3369; Eukaryota.
DR   InParanoid; Q69BT7; -.
DR   OrthoDB; 1504863at2759; -.
DR   PhylomeDB; Q69BT7; -.
DR   TreeFam; TF314561; -.
DR   Reactome; R-RNO-204005; COPII-mediated vesicle transport.
DR   Reactome; R-RNO-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR   PRO; PR:Q69BT7; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0030425; C:dendrite; ISO:RGD.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005795; C:Golgi stack; ISO:RGD.
DR   GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0045202; C:synapse; ISO:RGD.
DR   GO; GO:0008021; C:synaptic vesicle; ISO:RGD.
DR   GO; GO:0030008; C:TRAPP complex; ISS:UniProtKB.
DR   GO; GO:0006914; P:autophagy; ISS:UniProtKB.
DR   GO; GO:0016358; P:dendrite development; ISO:RGD.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; ISS:UniProtKB.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   InterPro; IPR007233; TRAPPC.
DR   PANTHER; PTHR23249; PTHR23249; 1.
DR   Pfam; PF04099; Sybindin; 1.
DR   SMART; SM01399; Sybindin; 1.
DR   SUPFAM; SSF64356; SSF64356; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW   Membrane; Postsynaptic cell membrane; Reference proteome; Synapse;
KW   Transport.
FT   CHAIN           1..219
FT                   /note="Trafficking protein particle complex subunit 4"
FT                   /id="PRO_0000330744"
FT   CONFLICT        86
FT                   /note="P -> L (in Ref. 2; AAH98628)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   219 AA;  24359 MW;  14CCF0E31C5E5282 CRC64;
     MAIFSVYVVN KAGGLIYQWD SYSPRAEAEK TFSYPLDLLL KLHDERVLVA FGQRDGIRVG
     HAVLAINGMD VNGKYTADGK EVLEYPGNSA NYPVSIRFGR PRLTSNEKLM LASMFHSLFA
     IGSQLSPEQG SSGIEMLETD TFKLHCFQTL TGIKFVVLAD PRQAGIDSLL RKIYEIYSDF
     ALKNPFYSLE MPIRCELFDQ NLKLALEVAE KAGTFGPGS