ID   TPPC5_MOUSE             Reviewed;         188 AA.
AC   Q9CQA1; Q8BJX6;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 131.
DE   RecName: Full=Trafficking protein particle complex subunit 5;
GN   Name=Trappc5;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Head, Pancreas, and Wolffian duct;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Heart, Kidney, Liver, Lung, Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May play a role in vesicular transport from endoplasmic
CC       reticulum to Golgi.
CC   -!- SUBUNIT: Component of the multisubunit TRAPP (transport protein
CC       particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3,
CC       TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and
CC       TRAPPC12. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q9CQA1; Q9Y296: TRAPPC4; Xeno; NbExp=2; IntAct=EBI-1172213, EBI-722888;
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}.
CC       Endoplasmic reticulum {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAPP small subunits family. BET3 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AK003633; BAB22901.1; -; mRNA.
DR   EMBL; AK007989; BAB25393.1; -; mRNA.
DR   EMBL; AK076212; BAC36257.1; -; mRNA.
DR   EMBL; AK078451; BAC37280.1; -; mRNA.
DR   EMBL; BC049179; AAH49179.1; -; mRNA.
DR   CCDS; CCDS22070.1; -.
DR   RefSeq; NP_079977.3; NM_025701.4.
DR   AlphaFoldDB; Q9CQA1; -.
DR   SMR; Q9CQA1; -.
DR   BioGRID; 211642; 7.
DR   ComplexPortal; CPX-4764; TRAPP II complex.
DR   ComplexPortal; CPX-4766; TRAPP III complex.
DR   IntAct; Q9CQA1; 5.
DR   MINT; Q9CQA1; -.
DR   STRING; 10090.ENSMUSP00000036541; -.
DR   iPTMnet; Q9CQA1; -.
DR   PhosphoSitePlus; Q9CQA1; -.
DR   SwissPalm; Q9CQA1; -.
DR   EPD; Q9CQA1; -.
DR   MaxQB; Q9CQA1; -.
DR   PaxDb; Q9CQA1; -.
DR   PeptideAtlas; Q9CQA1; -.
DR   PRIDE; Q9CQA1; -.
DR   ProteomicsDB; 259171; -.
DR   Antibodypedia; 24583; 102 antibodies from 24 providers.
DR   Ensembl; ENSMUST00000044857; ENSMUSP00000036541; ENSMUSG00000040236.
DR   Ensembl; ENSMUST00000207787; ENSMUSP00000146674; ENSMUSG00000040236.
DR   GeneID; 66682; -.
DR   KEGG; mmu:66682; -.
DR   UCSC; uc009ksk.2; mouse.
DR   CTD; 126003; -.
DR   MGI; MGI:1913932; Trappc5.
DR   VEuPathDB; HostDB:ENSMUSG00000040236; -.
DR   eggNOG; KOG3315; Eukaryota.
DR   GeneTree; ENSGT00390000000976; -.
DR   HOGENOM; CLU_073154_2_0_1; -.
DR   InParanoid; Q9CQA1; -.
DR   OMA; VPELQNK; -.
DR   OrthoDB; 1279541at2759; -.
DR   PhylomeDB; Q9CQA1; -.
DR   TreeFam; TF313795; -.
DR   Reactome; R-MMU-204005; COPII-mediated vesicle transport.
DR   Reactome; R-MMU-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR   BioGRID-ORCS; 66682; 24 hits in 71 CRISPR screens.
DR   ChiTaRS; Trappc5; mouse.
DR   PRO; PR:Q9CQA1; -.
DR   Proteomes; UP000000589; Chromosome 8.
DR   RNAct; Q9CQA1; protein.
DR   Bgee; ENSMUSG00000040236; Expressed in lens of camera-type eye and 256 other tissues.
DR   Genevisible; Q9CQA1; MM.
DR   GO; GO:0005737; C:cytoplasm; IC:ComplexPortal.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0030008; C:TRAPP complex; IDA:MGI.
DR   GO; GO:1990070; C:TRAPPI protein complex; IBA:GO_Central.
DR   GO; GO:1990071; C:TRAPPII protein complex; IBA:GO_Central.
DR   GO; GO:1990072; C:TRAPPIII protein complex; IBA:GO_Central.
DR   GO; GO:0048208; P:COPII vesicle coating; IC:ComplexPortal.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0006901; P:vesicle coating; IC:ComplexPortal.
DR   GO; GO:0099022; P:vesicle tethering; IC:ComplexPortal.
DR   CDD; cd14943; TRAPPC5_Trs31; 1.
DR   InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR   InterPro; IPR016696; TRAPP-I_su5.
DR   InterPro; IPR007194; TRAPP_component.
DR   PANTHER; PTHR20902; PTHR20902; 1.
DR   Pfam; PF04051; TRAPP; 1.
DR   PIRSF; PIRSF017479; TRAPP_I_complex_Trs31; 1.
DR   SUPFAM; SSF111126; SSF111126; 1.
PE   1: Evidence at protein level;
KW   Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; Phosphoprotein;
KW   Reference proteome; Transport.
FT   CHAIN           1..188
FT                   /note="Trafficking protein particle complex subunit 5"
FT                   /id="PRO_0000211580"
FT   MOD_RES         10
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8IUR0"
FT   CONFLICT        101
FT                   /note="E -> K (in Ref. 1; BAC37280)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   188 AA;  20795 MW;  AA5E3CA45DDD02C9 CRC64;
     MEARFTRGKS ALLERALVRP RTEVSLSAFA LLFSELVQHC QSRVFSVAEL QARLAALGRQ
     VGARVLDALV AREKGARRET KVLGALLFVK GAVWKALFGK EADKLEQAND DARTFYIIER
     EPLINTYISV PKENSTLNCA SFTAGIVEAV LTHSGFPAKV TAHWHKGTTL MIKFEEAVIA
     RDRALEGR