ID   TPPC5_PLAF7             Reviewed;         184 AA.
AC   Q7KQM2; A0A144A213;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Trafficking protein particle complex subunit 5;
DE   AltName: Full=41-2 protein antigen {ECO:0000250|UniProtKB:P15847};
GN   Name=TRAPPC5 {ECO:0000305}; ORFNames=PF14_0358, PF3D7_1437800;
OS   Plasmodium falciparum (isolate 3D7).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=36329;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=3D7;
RX   PubMed=12368864; DOI=10.1038/nature01097;
RA   Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA   Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA   Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA   Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA   Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA   Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA   Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA   Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT   "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL   Nature 419:498-511(2002).
CC   -!- FUNCTION: May play a role in vesicular transport from endoplasmic
CC       reticulum to Golgi. {ECO:0000250|UniProtKB:Q03337}.
CC   -!- SUBUNIT: Part of the multisubunit TRAPP (transport protein particle)
CC       complex. {ECO:0000250|UniProtKB:Q03337}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network
CC       {ECO:0000250|UniProtKB:Q03337}. Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q03337}. Cell membrane
CC       {ECO:0000250|UniProtKB:P15847}; Peripheral membrane protein
CC       {ECO:0000305}. Host membrane {ECO:0000250|UniProtKB:P15847}; Peripheral
CC       membrane protein {ECO:0000305}. Note=Schizont membrane, internal
CC       surface of parasitized erythrocytes and on membranous structures in the
CC       erythrocyte cytoplasm. {ECO:0000250|UniProtKB:P15847}.
CC   -!- MISCELLANEOUS: Blood stage antigen transported to the erythrocyte
CC       surface. {ECO:0000250|UniProtKB:P15847}.
CC   -!- SIMILARITY: Belongs to the TRAPP small subunits family. BET3 subfamily.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LN999946; CZU00076.1; -; Genomic_DNA.
DR   RefSeq; XP_001348532.1; XM_001348496.1.
DR   AlphaFoldDB; Q7KQM2; -.
DR   SMR; Q7KQM2; -.
DR   STRING; 5833.PF14_0358; -.
DR   PRIDE; Q7KQM2; -.
DR   EnsemblProtists; CZU00076; CZU00076; PF3D7_1437800.
DR   GeneID; 811940; -.
DR   KEGG; pfa:PF3D7_1437800; -.
DR   VEuPathDB; PlasmoDB:PF3D7_1437800; -.
DR   HOGENOM; CLU_073154_2_0_1; -.
DR   InParanoid; Q7KQM2; -.
DR   OMA; VPELQNK; -.
DR   PhylomeDB; Q7KQM2; -.
DR   Reactome; R-PFA-204005; COPII-mediated vesicle transport.
DR   Reactome; R-PFA-8876198; RAB GEFs exchange GTP for GDP on RABs.
DR   Proteomes; UP000001450; Chromosome 14.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0020002; C:host cell plasma membrane; TAS:GeneDB.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:1990070; C:TRAPPI protein complex; IBA:GO_Central.
DR   GO; GO:1990071; C:TRAPPII protein complex; IBA:GO_Central.
DR   GO; GO:1990072; C:TRAPPIII protein complex; IBA:GO_Central.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   CDD; cd14943; TRAPPC5_Trs31; 1.
DR   InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR   InterPro; IPR016696; TRAPP-I_su5.
DR   InterPro; IPR007194; TRAPP_component.
DR   PANTHER; PTHR20902; PTHR20902; 1.
DR   Pfam; PF04051; TRAPP; 1.
DR   PIRSF; PIRSF017479; TRAPP_I_complex_Trs31; 1.
DR   SUPFAM; SSF111126; SSF111126; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW   Host membrane; Malaria; Membrane; Reference proteome; Transport.
FT   CHAIN           1..184
FT                   /note="Trafficking protein particle complex subunit 5"
FT                   /id="PRO_0000211583"
SQ   SEQUENCE   184 AA;  21512 MW;  DB16CD15E8355963 CRC64;
     MDKSKSSIEK ELNRIKQDVS LSAFSILFSE MVQYCLYKSK RGYRIEDCLH EMGLRVGYKL
     NEYLTYKNKV KRSINIINIL TFISKHVWKY LFQHSSDLLK SQDSIYEYMI CDKNILLNKF
     INVPKDYGNI NCAAFAAGIV EGFLCSSEFQ ADVTAHTIHE GDDNYNTTIF IKFYPEVVER
     EKNH