ID   TPPC9_BOVIN             Reviewed;        1138 AA.
AC   Q32PH0; A1L534;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Trafficking protein particle complex subunit 9;
DE   AltName: Full=NIK- and IKBKB-binding protein;
GN   Name=TRAPPC9; Synonyms=NIBP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thymus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 366-1138.
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: Functions as an activator of NF-kappa-B through increased
CC       phosphorylation of the IKK complex. May function in neuronal cells
CC       differentiation. May play a role in vesicular transport from
CC       endoplasmic reticulum to Golgi.
CC   -!- SUBUNIT: Component of the multisubunit TRAPP (transport protein
CC       particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3,
CC       TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and
CC       TRAPPC12. Directly interacts with IKBKB and MAP3K14 (By similarity).
CC       {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q32PH0; PRO_0000038035 [P19711]; Xeno; NbExp=7; IntAct=EBI-9522367, EBI-9350549;
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250}.
CC       Endoplasmic reticulum {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC       Note=Processes and cell bodies of neurons. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NIBP family. {ECO:0000305}.
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DR   EMBL; BC108119; AAI08120.1; -; mRNA.
DR   EMBL; BT029821; ABM06084.1; -; mRNA.
DR   RefSeq; NP_001032551.1; NM_001037474.2.
DR   AlphaFoldDB; Q32PH0; -.
DR   IntAct; Q32PH0; 1.
DR   STRING; 9913.ENSBTAP00000037206; -.
DR   PaxDb; Q32PH0; -.
DR   PRIDE; Q32PH0; -.
DR   GeneID; 533451; -.
DR   KEGG; bta:533451; -.
DR   CTD; 83696; -.
DR   eggNOG; KOG1953; Eukaryota.
DR   InParanoid; Q32PH0; -.
DR   OrthoDB; 71855at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   InterPro; IPR013935; TRAPP_II_complex_Trs120.
DR   PANTHER; PTHR21512; PTHR21512; 1.
DR   Pfam; PF08626; TRAPPC9-Trs120; 2.
PE   1: Evidence at protein level;
KW   Cytoplasm; Differentiation; Endoplasmic reticulum; Golgi apparatus;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..1138
FT                   /note="Trafficking protein particle complex subunit 9"
FT                   /id="PRO_0000341585"
FT   MOD_RES         557
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96Q05"
FT   MOD_RES         944
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96Q05"
FT   CONFLICT        708
FT                   /note="K -> E (in Ref. 2; ABM06084)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        912
FT                   /note="G -> R (in Ref. 2; ABM06084)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1138 AA;  127004 MW;  9D51594839EB4E72 CRC64;
     MSVPDYMQCA EDHQTLLVVV QPVGIVSEEN FFRIYKRISS VSQISVRDSQ RALYIRYRHH
     YPPENSEWGD FQTHRKVVGL ITITDCFSAK DWPQIFEKFH VQKEIYGSTL YDSRLFVFGL
     QGEIAEQPRT DVAFYPSYED CATVEKRIED FVESLFIVLE SKRLDRATDK SGDKIPLLCV
     PFEKKDFVGL DTDSRHYKKR CQGRMRKHVG DLCLQAGMLQ DSLVHYHMSV ELLRSVNDFL
     WLGAALEGLC SASVIYHYPG GTGGKAGARR FPGSALPAEA ANRHRPGALT TNGINADTST
     EIGRAKNCLS PEDIIEKYKE AISYYSKYKN AGVIELEACV KAVRVLAIQK RSMEASEFLQ
     NAVYINLRQL SEEEKIQRYS ILSELYELIG FHRKSAFFKR VAAMQCVAPS ISEPGWRACY
     KLLLETLPGY SLSLDPQDFN KGTHRGWAAV QMRLLHELVY ASRRMGNPAL SVRHLSFLLQ
     TMLDFLSDQE KKDVTQSLEN YTSKCPGTME LLTLPDGLTL PPVPFTKLPI VRRVKLLDLP
     ASLRPQKMKS SLGPSVSAKS PFIYSPIIAH SRGEERSKKI DFQWVQGDVC EVQLMVYNPM
     PFELRVENMG LLTSGVEFES LPAALSLPAE SGLYPVTLVG VPQTTGTITV SGYHTTVFGV
     FSDCLLDSLP GIKTSGSTVE VIPALPRLQI STSLPRSAHS LQPSSGDKIS TNVSVQLYNG
     ETQQLVVRLE NIGMEPLEKL EVTSKILTTK EKLYGDFLSW KLEDTLAQFP LQPGKVATFT
     ISIKVKLDFS CQENLLQDLS DDGISVSGFP LCSPFRQVVR PRVESKPVNA AEGGRPGEPC
     HVKTLEAVLN FKYSGGPGHV EGYYRNLALG LHVEVEPSVF FTRVSTLPAT STRQCHLLLD
     VFNATEHELS VGARSDEELI LHAGECQRMA IQVDKFNFES FPESPADKGQ FANSKHLEEE
     RQEARGLEIN SKLDIHWTIP SLKRTGEASV EGLLNQLVLE HLQLAPLLWD VLVDGQPCDC
     QAAACRVGDP VRLEVRLTNR SPRSVGPFAL SVVPFQDHQN GVHSYDLRHA VSFVGSGTFY
     LDKVQPSGQA ACLGALLFLY TGDFFLHIRF HEDGPSKELP PSWFCLPSVH VRALEAQA