TPPC_ARATH
ID TPPC_ARATH Reviewed; 320 AA.
AC F4I1A6; Q9LM17;
DT 13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Probable trehalose-phosphate phosphatase C;
DE Short=AtTPPC;
DE EC=3.1.3.12;
DE AltName: Full=Trehalose 6-phosphate phosphatase;
GN Name=TPPC; OrderedLocusNames=At1g22210; ORFNames=F16L1.6;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=12508064; DOI=10.1093/jxb/erg039;
RA Eastmond P.J., Li Y., Graham I.A.;
RT "Is trehalose-6-phosphate a regulator of sugar metabolism in plants?";
RL J. Exp. Bot. 54:533-537(2003).
RN [4]
RP NOMENCLATURE.
RX PubMed=15181209; DOI=10.1104/pp.104.039503;
RA Schluepmann H., van Dijken A.J.H., Aghdasi M., Wobbes B., Paul M.,
RA Smeekens S.C.M.;
RT "Trehalose mediated growth inhibition of Arabidopsis seedlings is due to
RT trehalose-6-phosphate accumulation.";
RL Plant Physiol. 135:879-890(2004).
CC -!- FUNCTION: Removes the phosphate from trehalose 6-phosphate to produce
CC free trehalose. Trehalose accumulation in plant may improve abiotic
CC stress tolerance (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-
CC trehalose + phosphate; Xref=Rhea:RHEA:23420, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:16551, ChEBI:CHEBI:43474, ChEBI:CHEBI:58429; EC=3.1.3.12;
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000250};
CC -!- PATHWAY: Glycan biosynthesis; trehalose biosynthesis.
CC -!- SIMILARITY: Belongs to the trehalose phosphatase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF87852.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC073942; AAF87852.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE30212.1; -; Genomic_DNA.
DR PIR; G86354; G86354.
DR RefSeq; NP_173640.1; NM_102071.2.
DR AlphaFoldDB; F4I1A6; -.
DR SMR; F4I1A6; -.
DR STRING; 3702.AT1G22210.1; -.
DR PaxDb; F4I1A6; -.
DR PRIDE; F4I1A6; -.
DR ProteomicsDB; 228320; -.
DR DNASU; 838826; -.
DR EnsemblPlants; AT1G22210.1; AT1G22210.1; AT1G22210.
DR GeneID; 838826; -.
DR Gramene; AT1G22210.1; AT1G22210.1; AT1G22210.
DR KEGG; ath:AT1G22210; -.
DR Araport; AT1G22210; -.
DR TAIR; locus:2015051; AT1G22210.
DR eggNOG; KOG1050; Eukaryota.
DR HOGENOM; CLU_037265_1_1_1; -.
DR InParanoid; F4I1A6; -.
DR OMA; AYITDEM; -.
DR OrthoDB; 974358at2759; -.
DR UniPathway; UPA00299; -.
DR PRO; PR:F4I1A6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; F4I1A6; baseline and differential.
DR Genevisible; F4I1A6; AT.
DR GO; GO:0004805; F:trehalose-phosphatase activity; IBA:GO_Central.
DR GO; GO:0005992; P:trehalose biosynthetic process; IBA:GO_Central.
DR Gene3D; 3.40.50.1000; -; 2.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR006379; HAD-SF_hydro_IIB.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR044651; OTSB-like.
DR InterPro; IPR003337; Trehalose_PPase.
DR PANTHER; PTHR43768; PTHR43768; 1.
DR Pfam; PF02358; Trehalose_PPase; 1.
DR SUPFAM; SSF56784; SSF56784; 1.
DR TIGRFAMs; TIGR01484; HAD-SF-IIB; 1.
DR TIGRFAMs; TIGR00685; T6PP; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Reference proteome; Stress response.
FT CHAIN 1..320
FT /note="Probable trehalose-phosphate phosphatase C"
FT /id="PRO_0000417645"
SQ SEQUENCE 320 AA; 36363 MW; 4A1066386F63CD41 CRC64;
MKITDISGKI ETLVDSLRDM SPTRVRSSFS DEHVSENDDE RSSWIALHPS ALDMFEQIMR
DAEGKQIIMF LDYDGTLSLI TEDHDRAYIT DEMREVVKEV ATYFKTAIIS GRSTDKVQSF
VKLTGIHYAG SHGMDIKGPT NTDQSNQEEV MFQPASDYLP MIDEVVNVLK EKTKSIPGAT
VEHNKFCLTV HFRRVDETGW AALAEQVRLV LIDYPKLRLT QGRKVLELRP SIKWDKGKAL
EFLLNSLGIA ESKDVLPVYI GDDRTDEDAF KVLCERGQGF GIIVSKTIKE TYASYSLQDP
SQVKEFLERL VKWKKQTLGE
