TPPD_ARATH
ID TPPD_ARATH Reviewed; 369 AA.
AC Q67XC9; Q8LCM4; Q9C8B3;
DT 13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Probable trehalose-phosphate phosphatase D;
DE Short=AtTPPD;
DE EC=3.1.3.12;
DE AltName: Full=Trehalose 6-phosphate phosphatase;
GN Name=TPPD; OrderedLocusNames=At1g35910; ORFNames=F10O5.8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=12508064; DOI=10.1093/jxb/erg039;
RA Eastmond P.J., Li Y., Graham I.A.;
RT "Is trehalose-6-phosphate a regulator of sugar metabolism in plants?";
RL J. Exp. Bot. 54:533-537(2003).
RN [6]
RP NOMENCLATURE.
RX PubMed=15181209; DOI=10.1104/pp.104.039503;
RA Schluepmann H., van Dijken A.J.H., Aghdasi M., Wobbes B., Paul M.,
RA Smeekens S.C.M.;
RT "Trehalose mediated growth inhibition of Arabidopsis seedlings is due to
RT trehalose-6-phosphate accumulation.";
RL Plant Physiol. 135:879-890(2004).
CC -!- FUNCTION: Removes the phosphate from trehalose 6-phosphate to produce
CC free trehalose. Trehalose accumulation in plant may improve abiotic
CC stress tolerance (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-
CC trehalose + phosphate; Xref=Rhea:RHEA:23420, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:16551, ChEBI:CHEBI:43474, ChEBI:CHEBI:58429; EC=3.1.3.12;
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000250};
CC -!- PATHWAY: Glycan biosynthesis; trehalose biosynthesis.
CC -!- SIMILARITY: Belongs to the trehalose phosphatase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG51089.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC027032; AAG51089.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE31836.1; -; Genomic_DNA.
DR EMBL; AK176890; BAD44653.1; -; mRNA.
DR EMBL; AY086513; AAM63513.1; -; mRNA.
DR PIR; A86481; A86481.
DR RefSeq; NP_564464.1; NM_103289.5.
DR AlphaFoldDB; Q67XC9; -.
DR SMR; Q67XC9; -.
DR STRING; 3702.AT1G35910.1; -.
DR PaxDb; Q67XC9; -.
DR PRIDE; Q67XC9; -.
DR ProteomicsDB; 228296; -.
DR EnsemblPlants; AT1G35910.1; AT1G35910.1; AT1G35910.
DR GeneID; 840493; -.
DR Gramene; AT1G35910.1; AT1G35910.1; AT1G35910.
DR KEGG; ath:AT1G35910; -.
DR Araport; AT1G35910; -.
DR TAIR; locus:2007651; AT1G35910.
DR eggNOG; KOG1050; Eukaryota.
DR HOGENOM; CLU_037265_1_2_1; -.
DR InParanoid; Q67XC9; -.
DR OMA; FQAANEF; -.
DR OrthoDB; 974358at2759; -.
DR PhylomeDB; Q67XC9; -.
DR UniPathway; UPA00299; -.
DR PRO; PR:Q67XC9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q67XC9; baseline and differential.
DR Genevisible; Q67XC9; AT.
DR GO; GO:0009507; C:chloroplast; IDA:TAIR.
DR GO; GO:0015927; F:trehalase activity; IDA:TAIR.
DR GO; GO:0004805; F:trehalose-phosphatase activity; IDA:TAIR.
DR GO; GO:0006970; P:response to osmotic stress; IMP:TAIR.
DR GO; GO:0006979; P:response to oxidative stress; IMP:TAIR.
DR GO; GO:0009651; P:response to salt stress; IMP:TAIR.
DR GO; GO:0005992; P:trehalose biosynthetic process; IBA:GO_Central.
DR Gene3D; 3.40.50.1000; -; 2.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR006379; HAD-SF_hydro_IIB.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR044651; OTSB-like.
DR InterPro; IPR003337; Trehalose_PPase.
DR PANTHER; PTHR43768; PTHR43768; 1.
DR Pfam; PF02358; Trehalose_PPase; 1.
DR SUPFAM; SSF56784; SSF56784; 1.
DR TIGRFAMs; TIGR01484; HAD-SF-IIB; 1.
DR TIGRFAMs; TIGR00685; T6PP; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Reference proteome; Stress response.
FT CHAIN 1..369
FT /note="Probable trehalose-phosphate phosphatase D"
FT /id="PRO_0000417646"
FT REGION 63..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 79
FT /note="P -> T (in Ref. 4; AAM63513)"
FT /evidence="ECO:0000305"
FT CONFLICT 266
FT /note="R -> S (in Ref. 4; AAM63513)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 369 AA; 41598 MW; FB606D1627C9AAC7 CRC64;
MTNHNALISD AKGSIGVAVR VPNQSLFSPG GGRYISIPRK KLVQKLEADP SQTRIHTWIE
AMRASSPTRT RPGNISPLPE SDEEDEYSSW MAQHPSALTM FEEIAEASKG KQIVMFLDYD
GTLSPIVENP DRAYMSEEMR EAVKGVARYF PTAIVTGRCR DKVRRFVKLP GLYYAGSHGM
DIKGPSKRNK HNKNNKGVLF QAANEFLPMI DKVSKCLVEK MRDIEGANVE NNKFCVSVHY
RCVDQKDWGL VAEHVTSILS EYPKLRLTQG RKVLEIRPTI KWDKGKALEF LLESLGFANS
NDVLPIYIGD DRTDEDAFKV LRNKGQGFGI LVSKIPKETS ATYSLQEPSE VGEFLQRLVE
WKQMSLRGR
