TPPE_ARATH
ID TPPE_ARATH Reviewed; 354 AA.
AC Q67X99; Q9SIE5;
DT 13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Probable trehalose-phosphate phosphatase E;
DE Short=AtTPPE;
DE EC=3.1.3.12;
DE AltName: Full=Trehalose 6-phosphate phosphatase;
GN Name=TPPE; OrderedLocusNames=At2g22190; ORFNames=T26C19.15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 86-354.
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Carninci P., Hayashizaki Y.,
RA Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA Shinozaki K., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=12508064; DOI=10.1093/jxb/erg039;
RA Eastmond P.J., Li Y., Graham I.A.;
RT "Is trehalose-6-phosphate a regulator of sugar metabolism in plants?";
RL J. Exp. Bot. 54:533-537(2003).
RN [6]
RP INDUCTION, AND NOMENCLATURE.
RX PubMed=15181209; DOI=10.1104/pp.104.039503;
RA Schluepmann H., van Dijken A.J.H., Aghdasi M., Wobbes B., Paul M.,
RA Smeekens S.C.M.;
RT "Trehalose mediated growth inhibition of Arabidopsis seedlings is due to
RT trehalose-6-phosphate accumulation.";
RL Plant Physiol. 135:879-890(2004).
CC -!- FUNCTION: Removes the phosphate from trehalose 6-phosphate to produce
CC free trehalose. Trehalose accumulation in plant may improve abiotic
CC stress tolerance (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-
CC trehalose + phosphate; Xref=Rhea:RHEA:23420, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:16551, ChEBI:CHEBI:43474, ChEBI:CHEBI:58429; EC=3.1.3.12;
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000250};
CC -!- PATHWAY: Glycan biosynthesis; trehalose biosynthesis.
CC -!- INDUCTION: Not induced by trehalose. {ECO:0000269|PubMed:15181209}.
CC -!- SIMILARITY: Belongs to the trehalose phosphatase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD23621.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC007168; AAD23621.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC07276.1; -; Genomic_DNA.
DR EMBL; AK176920; BAD44683.1; -; mRNA.
DR EMBL; BT010648; AAQ89670.1; -; mRNA.
DR PIR; A84610; A84610.
DR RefSeq; NP_179809.2; NM_127787.3.
DR AlphaFoldDB; Q67X99; -.
DR SMR; Q67X99; -.
DR BioGRID; 2106; 1.
DR IntAct; Q67X99; 1.
DR STRING; 3702.AT2G22190.1; -.
DR PaxDb; Q67X99; -.
DR PRIDE; Q67X99; -.
DR DNASU; 816753; -.
DR EnsemblPlants; AT2G22190.1; AT2G22190.1; AT2G22190.
DR GeneID; 816753; -.
DR Gramene; AT2G22190.1; AT2G22190.1; AT2G22190.
DR KEGG; ath:AT2G22190; -.
DR Araport; AT2G22190; -.
DR TAIR; locus:2060390; AT2G22190.
DR eggNOG; KOG1050; Eukaryota.
DR HOGENOM; CLU_037265_1_1_1; -.
DR InParanoid; Q67X99; -.
DR OMA; EEHAAWM; -.
DR OrthoDB; 974358at2759; -.
DR PhylomeDB; Q67X99; -.
DR UniPathway; UPA00299; -.
DR PRO; PR:Q67X99; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q67X99; baseline and differential.
DR Genevisible; Q67X99; AT.
DR GO; GO:0009507; C:chloroplast; IDA:TAIR.
DR GO; GO:0004805; F:trehalose-phosphatase activity; IDA:TAIR.
DR GO; GO:0005992; P:trehalose biosynthetic process; IBA:GO_Central.
DR Gene3D; 3.40.50.1000; -; 2.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR006379; HAD-SF_hydro_IIB.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR044651; OTSB-like.
DR InterPro; IPR003337; Trehalose_PPase.
DR PANTHER; PTHR43768; PTHR43768; 1.
DR Pfam; PF02358; Trehalose_PPase; 1.
DR SUPFAM; SSF56784; SSF56784; 1.
DR TIGRFAMs; TIGR01484; HAD-SF-IIB; 1.
DR TIGRFAMs; TIGR00685; T6PP; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Reference proteome; Stress response.
FT CHAIN 1..354
FT /note="Probable trehalose-phosphate phosphatase E"
FT /id="PRO_0000417647"
SQ SEQUENCE 354 AA; 40251 MW; AC1577029B7F2EC8 CRC64;
MVRFIEENIT KMLETKAISN SEVLYVGGDD GDTSPTTKVL HDFQINSGGG LIRSWVDSMR
ACSPTRPKSF NSQSCWIKEH PSALNMFEEI LHKSEGKQIV MFLDYDGTLS PIVDDPDRAF
MSKKMRNTVR KLAKCFPTAI VSGRCREKVS SFVKLTELYY AGSHGMDIKG PEQGSKYKKE
NQSLLCQPAT EFLPVINEVY KKLVENTQSI PGAKVENNKF CASVHFRCVE ENKWSDLAHQ
VRSVLKNYPK LMLTQGRKVL EIRPIIKWDK GKALEFLLES LGYDNCTDVF PIYIGDDRTD
EDAFKILRDK KQGLGILVSK YAKETNASYS LQEPDEVMVF LERLVEWKQS RCGA
