ID   TPPI_ARATH              Reviewed;         369 AA.
AC   F4KFG5; Q9LX18;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Probable trehalose-phosphate phosphatase I;
DE            Short=AtTPPI;
DE            EC=3.1.3.12;
DE   AltName: Full=Trehalose 6-phosphate phosphatase;
GN   Name=TPPI; OrderedLocusNames=At5g10100; ORFNames=T31P16.90;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA   Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA   Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA   O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA   Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA   Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA   Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA   Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA   Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA   Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA   Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA   McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA   Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA   Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA   Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA   Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA   Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL   Nature 408:823-826(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY.
RX   PubMed=12508064; DOI=10.1093/jxb/erg039;
RA   Eastmond P.J., Li Y., Graham I.A.;
RT   "Is trehalose-6-phosphate a regulator of sugar metabolism in plants?";
RL   J. Exp. Bot. 54:533-537(2003).
RN   [4]
RP   NOMENCLATURE.
RX   PubMed=15181209; DOI=10.1104/pp.104.039503;
RA   Schluepmann H., van Dijken A.J.H., Aghdasi M., Wobbes B., Paul M.,
RA   Smeekens S.C.M.;
RT   "Trehalose mediated growth inhibition of Arabidopsis seedlings is due to
RT   trehalose-6-phosphate accumulation.";
RL   Plant Physiol. 135:879-890(2004).
CC   -!- FUNCTION: Removes the phosphate from trehalose 6-phosphate to produce
CC       free trehalose. Trehalose accumulation in plant may improve abiotic
CC       stress tolerance (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-
CC         trehalose + phosphate; Xref=Rhea:RHEA:23420, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:16551, ChEBI:CHEBI:43474, ChEBI:CHEBI:58429; EC=3.1.3.12;
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000250};
CC   -!- PATHWAY: Glycan biosynthesis; trehalose biosynthesis.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences.;
CC       Name=1;
CC         IsoId=F4KFG5-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the trehalose phosphatase family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB92051.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL356332; CAB92051.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002688; ANM70969.1; -; Genomic_DNA.
DR   PIR; T50014; T50014.
DR   RefSeq; NP_196572.2; NM_121048.3. [F4KFG5-1]
DR   AlphaFoldDB; F4KFG5; -.
DR   SMR; F4KFG5; -.
DR   STRING; 3702.AT5G10100.1; -.
DR   PaxDb; F4KFG5; -.
DR   PRIDE; F4KFG5; -.
DR   ProteomicsDB; 228321; -. [F4KFG5-1]
DR   EnsemblPlants; AT5G10100.3; AT5G10100.3; AT5G10100. [F4KFG5-1]
DR   GeneID; 830874; -.
DR   Gramene; AT5G10100.3; AT5G10100.3; AT5G10100. [F4KFG5-1]
DR   KEGG; ath:AT5G10100; -.
DR   Araport; AT5G10100; -.
DR   TAIR; locus:2184063; AT5G10100.
DR   eggNOG; KOG1050; Eukaryota.
DR   HOGENOM; CLU_037265_1_1_1; -.
DR   InParanoid; F4KFG5; -.
DR   UniPathway; UPA00299; -.
DR   PRO; PR:F4KFG5; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; F4KFG5; baseline and differential.
DR   Genevisible; F4KFG5; AT.
DR   GO; GO:0004805; F:trehalose-phosphatase activity; IBA:GO_Central.
DR   GO; GO:0005992; P:trehalose biosynthetic process; IBA:GO_Central.
DR   Gene3D; 3.40.50.1000; -; 1.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR006379; HAD-SF_hydro_IIB.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR044651; OTSB-like.
DR   InterPro; IPR003337; Trehalose_PPase.
DR   PANTHER; PTHR43768; PTHR43768; 1.
DR   Pfam; PF02358; Trehalose_PPase; 1.
DR   SUPFAM; SSF56784; SSF56784; 1.
DR   TIGRFAMs; TIGR01484; HAD-SF-IIB; 1.
DR   TIGRFAMs; TIGR00685; T6PP; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Hydrolase; Reference proteome; Stress response.
FT   CHAIN           1..369
FT                   /note="Probable trehalose-phosphate phosphatase I"
FT                   /id="PRO_0000417651"
SQ   SEQUENCE   369 AA;  41974 MW;  9656C70C0B3BFE7A CRC64;
     MSASQNIVVS ETTMSSIIPN NNNNNNNSSS QKLPPCLISI SKKKLLKNID IINGGGQRIN
     AWVDSMRASS PTHLKSLPSS ISTQQQLNSW IMQHPSALEK FEQIMEASRG KQIVMFLDYD
     GTLSPIVDDP DKAFMSSKMR RTVKKLAKCF PTAIVTGRCI DKVYNFVKLA ELYYAGSHGM
     DIKGPAKGFS RHKRVKQSLL YQPANDYLPM IDEVYRQLLE KTKSTPGAKV ENHKFCASVH
     FRCVDEKKWS ELVLQVRSVL KKFPTLQLTQ GRKVFEIRPM IEWDKGKALE FLLESLGFGN
     TNNVFPVYIG DDRTDEDAFK MLRDRGEGFG ILVSKFPKDT DASYSLQDPS EVMDFLRRLV
     EWKQMQPRM