TPPJ_ARATH
ID TPPJ_ARATH Reviewed; 370 AA.
AC Q5HZ05; Q9FJQ1;
DT 13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Probable trehalose-phosphate phosphatase J;
DE Short=AtTPPJ;
DE EC=3.1.3.12;
DE AltName: Full=Trehalose 6-phosphate phosphatase;
GN Name=TPPJ; OrderedLocusNames=At5g65140; ORFNames=MQN23.7;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9734815; DOI=10.1093/dnares/5.3.203;
RA Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence
RT features of the regions of 1,367,185 bp covered by 19 physically assigned
RT P1 and TAC clones.";
RL DNA Res. 5:203-216(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Kim C.J., Chen H., Cheuk R.F., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP INDUCTION BY CADMIUM.
RX PubMed=11520870; DOI=10.1093/jexbot/52.362.1817;
RA Vogel G., Fiehn O., Jean-Richard-dit-Bressel L., Boller T., Wiemken A.,
RA Aeschbacher R.A., Wingler A.;
RT "Trehalose metabolism in Arabidopsis: occurrence of trehalose and molecular
RT cloning and characterization of trehalose-6-phosphate synthase
RT homologues.";
RL J. Exp. Bot. 52:1817-1826(2001).
RN [6]
RP GENE FAMILY.
RX PubMed=12508064; DOI=10.1093/jxb/erg039;
RA Eastmond P.J., Li Y., Graham I.A.;
RT "Is trehalose-6-phosphate a regulator of sugar metabolism in plants?";
RL J. Exp. Bot. 54:533-537(2003).
RN [7]
RP NOMENCLATURE.
RX PubMed=15181209; DOI=10.1104/pp.104.039503;
RA Schluepmann H., van Dijken A.J.H., Aghdasi M., Wobbes B., Paul M.,
RA Smeekens S.C.M.;
RT "Trehalose mediated growth inhibition of Arabidopsis seedlings is due to
RT trehalose-6-phosphate accumulation.";
RL Plant Physiol. 135:879-890(2004).
CC -!- FUNCTION: Removes the phosphate from trehalose 6-phosphate to produce
CC free trehalose. Trehalose accumulation in plant may improve abiotic
CC stress tolerance (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha,alpha-trehalose 6-phosphate + H2O = alpha,alpha-
CC trehalose + phosphate; Xref=Rhea:RHEA:23420, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:16551, ChEBI:CHEBI:43474, ChEBI:CHEBI:58429; EC=3.1.3.12;
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000250};
CC -!- PATHWAY: Glycan biosynthesis; trehalose biosynthesis.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q5HZ05-1; Sequence=Displayed;
CC -!- INDUCTION: By cadmium in roots (at protein level).
CC {ECO:0000269|PubMed:11520870}.
CC -!- SIMILARITY: Belongs to the trehalose phosphatase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB11650.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB013395; BAB11650.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED98007.1; -; Genomic_DNA.
DR EMBL; BT020466; AAW38967.1; -; mRNA.
DR EMBL; BT020519; AAW39020.1; -; mRNA.
DR EMBL; AK221501; BAD94722.1; -; mRNA.
DR RefSeq; NP_201319.2; NM_125913.5. [Q5HZ05-1]
DR AlphaFoldDB; Q5HZ05; -.
DR SMR; Q5HZ05; -.
DR STRING; 3702.AT5G65140.1; -.
DR iPTMnet; Q5HZ05; -.
DR PaxDb; Q5HZ05; -.
DR PRIDE; Q5HZ05; -.
DR ProteomicsDB; 228322; -. [Q5HZ05-1]
DR EnsemblPlants; AT5G65140.1; AT5G65140.1; AT5G65140. [Q5HZ05-1]
DR GeneID; 836638; -.
DR Gramene; AT5G65140.1; AT5G65140.1; AT5G65140. [Q5HZ05-1]
DR KEGG; ath:AT5G65140; -.
DR Araport; AT5G65140; -.
DR TAIR; locus:2171850; AT5G65140.
DR eggNOG; KOG1050; Eukaryota.
DR HOGENOM; CLU_037265_1_2_1; -.
DR InParanoid; Q5HZ05; -.
DR OMA; ITSKMRR; -.
DR OrthoDB; 974358at2759; -.
DR PhylomeDB; Q5HZ05; -.
DR UniPathway; UPA00299; -.
DR PRO; PR:Q5HZ05; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q5HZ05; baseline and differential.
DR Genevisible; Q5HZ05; AT.
DR GO; GO:0005730; C:nucleolus; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0004805; F:trehalose-phosphatase activity; IBA:GO_Central.
DR GO; GO:0046686; P:response to cadmium ion; IEP:TAIR.
DR GO; GO:0005992; P:trehalose biosynthetic process; IBA:GO_Central.
DR Gene3D; 3.40.50.1000; -; 2.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR006379; HAD-SF_hydro_IIB.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR044651; OTSB-like.
DR InterPro; IPR003337; Trehalose_PPase.
DR PANTHER; PTHR43768; PTHR43768; 1.
DR Pfam; PF02358; Trehalose_PPase; 1.
DR SUPFAM; SSF56784; SSF56784; 1.
DR TIGRFAMs; TIGR01484; HAD-SF-IIB; 1.
DR TIGRFAMs; TIGR00685; T6PP; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Hydrolase; Reference proteome; Stress response.
FT CHAIN 1..370
FT /note="Probable trehalose-phosphate phosphatase J"
FT /id="PRO_0000417652"
SQ SEQUENCE 370 AA; 41758 MW; 4ADEAB2EA5B5B3C5 CRC64;
MVSQNVVVSD AKTGIITVST VSNSSVFTPT AQKPPTAPGY ISVSKKKLLK NLEINGADQS
QRLNSWVDSM RASSPTHLKS LSSFSSEEEH NSWIKRHPSA LNMFERIIEE ARGKQIVMFL
DYDGTLSPIV DDPDRAFMTS KMRRTVKKMA KCFPTSIVTG RCIDKVYSFV KLAELYYAGS
HGMDIKGPTK GFSRYNKDKP SVLYQPAGDF LPMIDEVYKQ LVEKTKSTPG AKVENNKFCL
SVHFRCVDEK KWSELASKVR SVVKNYPTLK LSQGRKVFEI RPIIKWNKGK ALEFLLESLG
FENCNDVFPI YIGDDKTDED AFKLLRGRGQ GFGILVSKFP KDTSASYSLQ DPPEVMNFLG
RLVEWKQMQQ
