ID   TPPP2_BOVIN             Reviewed;         171 AA.
AC   Q3T077;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Tubulin polymerization-promoting protein family member 2 {ECO:0000250|UniProtKB:P59282};
GN   Name=TPPP2 {ECO:0000250|UniProtKB:P59282};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable regulator of microtubule dynamics required for sperm
CC       motility (By similarity). In contrast to other members of the family,
CC       has no microtubule bundling activity (By similarity).
CC       {ECO:0000250|UniProtKB:P59282, ECO:0000250|UniProtKB:Q0P5Y3}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P59282}. Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:Q0P5Y3}. Note=Present in the middle piece of
CC       sperm tail. {ECO:0000250|UniProtKB:Q0P5Y3}.
CC   -!- SIMILARITY: Belongs to the TPPP family. {ECO:0000305}.
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DR   EMBL; BC102535; AAI02536.1; -; mRNA.
DR   RefSeq; NP_001029456.1; NM_001034284.2.
DR   AlphaFoldDB; Q3T077; -.
DR   SMR; Q3T077; -.
DR   STRING; 9913.ENSBTAP00000000433; -.
DR   PaxDb; Q3T077; -.
DR   PRIDE; Q3T077; -.
DR   Ensembl; ENSBTAT00000000433; ENSBTAP00000000433; ENSBTAG00000000328.
DR   GeneID; 507212; -.
DR   KEGG; bta:507212; -.
DR   CTD; 122664; -.
DR   VEuPathDB; HostDB:ENSBTAG00000000328; -.
DR   VGNC; VGNC:36259; TPPP2.
DR   eggNOG; KOG4070; Eukaryota.
DR   GeneTree; ENSGT00940000153875; -.
DR   HOGENOM; CLU_091734_0_0_1; -.
DR   InParanoid; Q3T077; -.
DR   OMA; RAKNART; -.
DR   OrthoDB; 1317210at2759; -.
DR   TreeFam; TF314440; -.
DR   Proteomes; UP000009136; Chromosome 10.
DR   Bgee; ENSBTAG00000000328; Expressed in semen and 64 other tissues.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0036126; C:sperm flagellum; ISS:UniProtKB.
DR   GO; GO:0015631; F:tubulin binding; IEA:Ensembl.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0032273; P:positive regulation of protein polymerization; IBA:GO_Central.
DR   GO; GO:1901317; P:regulation of flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR008907; P25-alpha.
DR   InterPro; IPR030794; TPPP2.
DR   PANTHER; PTHR12932; PTHR12932; 1.
DR   PANTHER; PTHR12932:SF21; PTHR12932:SF21; 1.
DR   Pfam; PF05517; p25-alpha; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cytoplasm; Differentiation; Flagellum;
KW   Reference proteome; Spermatogenesis.
FT   CHAIN           1..171
FT                   /note="Tubulin polymerization-promoting protein family
FT                   member 2"
FT                   /id="PRO_0000289002"
FT   REGION          120..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        125..146
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   171 AA;  18564 MW;  CC7E795FA77BF30B CRC64;
     MASEAERTFQ RFAVFGESSS SGTEMNNKNF SKLCKDCGIM DGKTVTSTDV DIVFSKVKAK
     NARTITFQQF QEAMKELGQK RFKGKSPDEA LENIYKLMEG KDPATTGVTK ATTVGGVSRL
     TDTSKYTGTH KERFDESGKG KGIAGREDVT DNSGYVSGYK GAGTYDKKGS N