ID   TPPP2_MACFA             Reviewed;         170 AA.
AC   Q4R3A0;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Tubulin polymerization-promoting protein family member 2;
GN   Name=TPPP2; ORFNames=QtsA-18383;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable regulator of microtubule dynamics required for sperm
CC       motility (By similarity). In contrast to other members of the family,
CC       has no microtubule bundling activity (By similarity).
CC       {ECO:0000250|UniProtKB:P59282, ECO:0000250|UniProtKB:Q0P5Y3}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P59282}. Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:Q0P5Y3}. Note=Present in the middle piece of
CC       sperm tail. {ECO:0000250|UniProtKB:Q0P5Y3}.
CC   -!- SIMILARITY: Belongs to the TPPP family. {ECO:0000305}.
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DR   EMBL; AB179366; BAE02417.1; -; mRNA.
DR   RefSeq; NP_001272207.1; NM_001285278.1.
DR   RefSeq; XP_005560799.1; XM_005560742.1.
DR   RefSeq; XP_015308720.1; XM_015453234.1.
DR   AlphaFoldDB; Q4R3A0; -.
DR   SMR; Q4R3A0; -.
DR   STRING; 9541.XP_005560798.1; -.
DR   Ensembl; ENSMFAT00000021973; ENSMFAP00000003313; ENSMFAG00000001424.
DR   GeneID; 101925360; -.
DR   KEGG; mcf:101925360; -.
DR   CTD; 122664; -.
DR   VEuPathDB; HostDB:ENSMFAG00000001424; -.
DR   eggNOG; KOG4070; Eukaryota.
DR   GeneTree; ENSGT00940000153875; -.
DR   OMA; RAKNART; -.
DR   OrthoDB; 1317210at2759; -.
DR   Proteomes; UP000233100; Chromosome 7.
DR   Bgee; ENSMFAG00000001424; Expressed in multicellular organism.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0036126; C:sperm flagellum; ISS:UniProtKB.
DR   GO; GO:0015631; F:tubulin binding; IEA:Ensembl.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:1901317; P:regulation of flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR008907; P25-alpha.
DR   InterPro; IPR030794; TPPP2.
DR   PANTHER; PTHR12932; PTHR12932; 1.
DR   PANTHER; PTHR12932:SF21; PTHR12932:SF21; 1.
DR   Pfam; PF05517; p25-alpha; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cytoplasm; Differentiation; Flagellum;
KW   Reference proteome; Spermatogenesis.
FT   CHAIN           1..170
FT                   /note="Tubulin polymerization-promoting protein family
FT                   member 2"
FT                   /id="PRO_0000289003"
FT   REGION          127..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..142
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   170 AA;  18420 MW;  B1B148C3A6192C34 CRC64;
     MASEAEKTFN RFAAFGESSS SGTEMNNKNF SKLCKDCGIM DGKTVTSTDV DIVFSKVKAK
     NARTITFQQF KEAVKELGQK RFKGKSPDEV LESIYGLMEG KDPATTGATK ATTVGAVDRL
     TDTSKYTGTH KERFDESGKG KGIAGREVMN DNTGYVSGYK GAGTYDKKTK