ID   TPPP3_BOVIN             Reviewed;         176 AA.
AC   Q3ZCC8;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Tubulin polymerization-promoting protein family member 3;
GN   Name=TPPP3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=17105200; DOI=10.1021/bi061305e;
RA   Vincze O., Toekesi N., Olah J., Hlavanda E., Zotter A., Horvath I.,
RA   Lehotzky A., Tirian L., Medzihradszky K.F., Kovacs J., Orosz F., Ovadi J.;
RT   "Tubulin polymerization promoting proteins (TPPPs): members of a new family
RT   with distinct structures and functions.";
RL   Biochemistry 45:13818-13826(2006).
CC   -!- FUNCTION: Regulator of microtubule dynamic that has microtubule
CC       bundling activity (By similarity). Required for embryo implantation;
CC       possibly by regulating beta-catenin (By similarity). Also required for
CC       decidualization via regulation of beta-catenin (By similarity).
CC       {ECO:0000250|UniProtKB:Q9BW30, ECO:0000250|UniProtKB:Q9CRB6}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BW30}.
CC       Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9BW30}.
CC   -!- SIMILARITY: Belongs to the TPPP family. {ECO:0000305}.
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DR   EMBL; BC102515; AAI02516.1; -; mRNA.
DR   RefSeq; NP_001029946.1; NM_001034774.2.
DR   RefSeq; XP_005218783.1; XM_005218726.3.
DR   AlphaFoldDB; Q3ZCC8; -.
DR   SMR; Q3ZCC8; -.
DR   STRING; 9913.ENSBTAP00000026407; -.
DR   PaxDb; Q3ZCC8; -.
DR   GeneID; 614988; -.
DR   KEGG; bta:614988; -.
DR   CTD; 51673; -.
DR   eggNOG; KOG4070; Eukaryota.
DR   HOGENOM; CLU_091734_0_0_1; -.
DR   InParanoid; Q3ZCC8; -.
DR   OrthoDB; 1317210at2759; -.
DR   TreeFam; TF314440; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0015631; F:tubulin binding; ISS:UniProtKB.
DR   GO; GO:0046697; P:decidualization; ISS:UniProtKB.
DR   GO; GO:0007566; P:embryo implantation; ISS:UniProtKB.
DR   GO; GO:0001578; P:microtubule bundle formation; ISS:UniProtKB.
DR   GO; GO:0046785; P:microtubule polymerization; IEA:InterPro.
DR   GO; GO:0032273; P:positive regulation of protein polymerization; IBA:GO_Central.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR008907; P25-alpha.
DR   InterPro; IPR030795; TPPP3.
DR   PANTHER; PTHR12932; PTHR12932; 1.
DR   PANTHER; PTHR12932:SF16; PTHR12932:SF16; 1.
DR   Pfam; PF05517; p25-alpha; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Cytoplasm; Cytoskeleton; Microtubule; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BW30"
FT   CHAIN           2..176
FT                   /note="Tubulin polymerization-promoting protein family
FT                   member 3"
FT                   /id="PRO_0000289005"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BW30"
SQ   SEQUENCE   176 AA;  18942 MW;  9C631633754BB863 CRC64;
     MAASTDVAGL EESFRKFAIH GDPKASGHEM NGKNWAKLCK DCKVADGKAV TGTDVDIVFS
     KVKAKSARVI NYEEFKKALE ELAPKRFKGK SKEEAFDAIC QLVAGKEPAN VGVTKAKTGG
     AVERLTDTSK YTGSHKERFD ESGKGKGIAG RQDILDDSGY VSAYKNAGTY DAKVKK