ID   TPPP3_RAT               Reviewed;         176 AA.
AC   Q5PPN5;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Tubulin polymerization-promoting protein family member 3;
GN   Name=Tppp3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Regulator of microtubule dynamic that has microtubule
CC       bundling activity (By similarity). Required for embryo implantation;
CC       possibly by regulating beta-catenin (By similarity). Also required for
CC       decidualization via regulation of beta-catenin (By similarity).
CC       {ECO:0000250|UniProtKB:Q9BW30, ECO:0000250|UniProtKB:Q9CRB6}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BW30}.
CC       Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9BW30}.
CC   -!- SIMILARITY: Belongs to the TPPP family. {ECO:0000305}.
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DR   EMBL; BC087585; AAH87585.1; -; mRNA.
DR   RefSeq; NP_001009639.1; NM_001009639.1.
DR   RefSeq; XP_006255526.1; XM_006255464.3.
DR   AlphaFoldDB; Q5PPN5; -.
DR   BMRB; Q5PPN5; -.
DR   SMR; Q5PPN5; -.
DR   BioGRID; 253713; 1.
DR   STRING; 10116.ENSRNOP00000022863; -.
DR   iPTMnet; Q5PPN5; -.
DR   PhosphoSitePlus; Q5PPN5; -.
DR   PaxDb; Q5PPN5; -.
DR   PRIDE; Q5PPN5; -.
DR   Ensembl; ENSRNOT00000022863; ENSRNOP00000022863; ENSRNOG00000016890.
DR   GeneID; 291966; -.
DR   KEGG; rno:291966; -.
DR   UCSC; RGD:1305061; rat.
DR   CTD; 51673; -.
DR   RGD; 1305061; Tppp3.
DR   eggNOG; KOG4070; Eukaryota.
DR   GeneTree; ENSGT00940000153875; -.
DR   HOGENOM; CLU_091734_0_0_1; -.
DR   InParanoid; Q5PPN5; -.
DR   OMA; PKASGHE; -.
DR   OrthoDB; 1317210at2759; -.
DR   PhylomeDB; Q5PPN5; -.
DR   TreeFam; TF314440; -.
DR   PRO; PR:Q5PPN5; -.
DR   Proteomes; UP000002494; Chromosome 19.
DR   Bgee; ENSRNOG00000016890; Expressed in lung and 20 other tissues.
DR   Genevisible; Q5PPN5; RN.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0097427; C:microtubule bundle; IEA:Ensembl.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR   GO; GO:0015631; F:tubulin binding; ISS:UniProtKB.
DR   GO; GO:0046697; P:decidualization; ISS:UniProtKB.
DR   GO; GO:0007566; P:embryo implantation; ISS:UniProtKB.
DR   GO; GO:0001578; P:microtubule bundle formation; ISS:UniProtKB.
DR   GO; GO:0046785; P:microtubule polymerization; IEA:InterPro.
DR   GO; GO:0032273; P:positive regulation of protein polymerization; IBA:GO_Central.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR008907; P25-alpha.
DR   InterPro; IPR030795; TPPP3.
DR   PANTHER; PTHR12932; PTHR12932; 1.
DR   PANTHER; PTHR12932:SF16; PTHR12932:SF16; 1.
DR   Pfam; PF05517; p25-alpha; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Cytoskeleton; Microtubule; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BW30"
FT   CHAIN           2..176
FT                   /note="Tubulin polymerization-promoting protein family
FT                   member 3"
FT                   /id="PRO_0000289006"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9BW30"
SQ   SEQUENCE   176 AA;  18980 MW;  75BA1820E266B406 CRC64;
     MAASTDIAGL EESFRKFAIH GDPKASGQEM NGKNWAKLCK DCKVADGKAV TGTDVDIVFS
     KVKAKSARVI NYEEFKKALE ELATKRFKGK TKEEAFDAIC QLIAGKEPAN IGVTKAKTGG
     AVDRLTDTSK YTGSHKERFD ESGKGKGIAG RQDILDDSGY VSAYKNAGTY DAKVKK