ID   TPPP3_XENLA             Reviewed;         176 AA.
AC   Q2VPM9;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Tubulin polymerization-promoting protein family member 3;
GN   Name=tppp3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of microtubule dynamic that has microtubule
CC       bundling activity. {ECO:0000250|UniProtKB:Q9BW30}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BW30}.
CC       Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9BW30}.
CC   -!- SIMILARITY: Belongs to the TPPP family. {ECO:0000305}.
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DR   EMBL; BC108514; AAI08515.1; -; mRNA.
DR   RefSeq; NP_001089831.1; NM_001096362.1.
DR   AlphaFoldDB; Q2VPM9; -.
DR   SMR; Q2VPM9; -.
DR   DNASU; 734897; -.
DR   GeneID; 734897; -.
DR   KEGG; xla:734897; -.
DR   CTD; 734897; -.
DR   Xenbase; XB-GENE-6078105; tppp3.L.
DR   OrthoDB; 1317210at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 734897; Expressed in brain and 14 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0015631; F:tubulin binding; ISS:UniProtKB.
DR   GO; GO:0001578; P:microtubule bundle formation; ISS:UniProtKB.
DR   GO; GO:0046785; P:microtubule polymerization; IEA:InterPro.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR008907; P25-alpha.
DR   InterPro; IPR030795; TPPP3.
DR   PANTHER; PTHR12932; PTHR12932; 1.
DR   PANTHER; PTHR12932:SF16; PTHR12932:SF16; 1.
DR   Pfam; PF05517; p25-alpha; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Microtubule; Reference proteome.
FT   CHAIN           1..176
FT                   /note="Tubulin polymerization-promoting protein family
FT                   member 3"
FT                   /id="PRO_0000289007"
FT   REGION          132..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   176 AA;  19094 MW;  F7CEE47F13581494 CRC64;
     MAENSDITSL EDSFRKFAIY GDTKATGQEM TGKNWSKLCK DCKVNDGKAV TGTDVDIVFS
     KVKAKSARVI TYEEFTKALE ELSAKRFKGK SKEEAYEAIC KLVAGKEPVS AGITKAAATG
     AVDRLTDTSK YTGSHKERFD QTGKGKGKSG RETIVENTGY VGSYKLAGTY DAKVKK