ID   TPPP3_XENTR             Reviewed;         176 AA.
AC   A4IIY2;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Tubulin polymerization-promoting protein family member 3;
GN   Name=tppp3;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulator of microtubule dynamic that has microtubule
CC       bundling activity. {ECO:0000250|UniProtKB:Q9BW30}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BW30}.
CC       Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9BW30}.
CC   -!- SIMILARITY: Belongs to the TPPP family. {ECO:0000305}.
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DR   EMBL; BC136199; AAI36200.1; -; mRNA.
DR   RefSeq; NP_001096466.1; NM_001102996.1.
DR   RefSeq; XP_012815936.1; XM_012960482.2.
DR   RefSeq; XP_012815938.1; XM_012960484.2.
DR   AlphaFoldDB; A4IIY2; -.
DR   SMR; A4IIY2; -.
DR   STRING; 8364.ENSXETP00000000724; -.
DR   PaxDb; A4IIY2; -.
DR   DNASU; 100125085; -.
DR   Ensembl; ENSXETT00000000724; ENSXETP00000000724; ENSXETG00000000345.
DR   GeneID; 100125085; -.
DR   KEGG; xtr:100125085; -.
DR   CTD; 51673; -.
DR   Xenbase; XB-GENE-955234; tppp3.
DR   eggNOG; KOG4070; Eukaryota.
DR   HOGENOM; CLU_091734_0_0_1; -.
DR   InParanoid; A4IIY2; -.
DR   OMA; GYVNAYK; -.
DR   OrthoDB; 1317210at2759; -.
DR   PhylomeDB; A4IIY2; -.
DR   TreeFam; TF314440; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000000345; Expressed in brain and 7 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0015631; F:tubulin binding; ISS:UniProtKB.
DR   GO; GO:0001578; P:microtubule bundle formation; ISS:UniProtKB.
DR   GO; GO:0046785; P:microtubule polymerization; IEA:InterPro.
DR   GO; GO:0032273; P:positive regulation of protein polymerization; IBA:GO_Central.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR008907; P25-alpha.
DR   InterPro; IPR030795; TPPP3.
DR   PANTHER; PTHR12932; PTHR12932; 1.
DR   PANTHER; PTHR12932:SF16; PTHR12932:SF16; 1.
DR   Pfam; PF05517; p25-alpha; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Cytoskeleton; Microtubule; Reference proteome.
FT   CHAIN           1..176
FT                   /note="Tubulin polymerization-promoting protein family
FT                   member 3"
FT                   /id="PRO_0000289008"
FT   REGION          126..152
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        129..151
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   176 AA;  19087 MW;  FFC4978D51E14A58 CRC64;
     MAENSDLTSL EESFRKFAIY GDTKATGQEM TGKNWAKLCK DCKVIDGKSV TGTDVDIVFS
     KVKGKSARVI TCEEFKKALE ELSGKRFKGK SKEEAYEAIC KLVVGKEPVS AGITKPAATG
     AVDRLTDTSK YTGSHKERFD ESGKGKGKGG RETIVENTGY VSSYKLAGTY DAKVKK