TPPP_CAEEL
ID TPPP_CAEEL Reviewed; 180 AA.
AC P91127;
DT 12-FEB-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Tubulin polymerization-promoting protein homolog {ECO:0000312|WormBase:C32E8.3};
GN Name=tppp-1 {ECO:0000312|WormBase:C32E8.3};
GN ORFNames=C32E8.3 {ECO:0000312|WormBase:C32E8.3};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP STRUCTURE BY NMR OF 1-115.
RX PubMed=14739645; DOI=10.1023/b:jnmr.0000012832.71049.bf;
RA Monleon D., Chiang Y., Aramini J.M., Swapna G.V., Macapagal D.,
RA Gunsalus K.C., Kim S., Szyperski T., Montelione G.T.;
RT "Backbone 1H, 15N and 13C assignments for the 21 kDa Caenorhabditis elegans
RT homologue of 'brain-specific' protein.";
RL J. Biomol. NMR 28:91-92(2004).
CC -!- FUNCTION: Regulator of microtubule dynamics.
CC {ECO:0000250|UniProtKB:O94811}.
CC -!- SIMILARITY: Belongs to the TPPP family. {ECO:0000305}.
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DR EMBL; FO080749; CCD66401.1; -; Genomic_DNA.
DR PIR; T25598; T25598.
DR RefSeq; NP_491219.1; NM_058818.3.
DR PDB; 1PUL; NMR; -; A=1-115.
DR PDBsum; 1PUL; -.
DR AlphaFoldDB; P91127; -.
DR BMRB; P91127; -.
DR SMR; P91127; -.
DR BioGRID; 37422; 3.
DR STRING; 6239.C32E8.3; -.
DR EPD; P91127; -.
DR PaxDb; P91127; -.
DR PeptideAtlas; P91127; -.
DR EnsemblMetazoa; C32E8.3.1; C32E8.3.1; WBGene00016321.
DR GeneID; 171948; -.
DR KEGG; cel:CELE_C32E8.3; -.
DR UCSC; C32E8.3; c. elegans.
DR CTD; 171948; -.
DR WormBase; C32E8.3; CE08527; WBGene00016321; tppp-1.
DR eggNOG; KOG4070; Eukaryota.
DR GeneTree; ENSGT00940000153875; -.
DR HOGENOM; CLU_091734_0_0_1; -.
DR InParanoid; P91127; -.
DR OMA; HMYGLVA; -.
DR OrthoDB; 1317210at2759; -.
DR PhylomeDB; P91127; -.
DR EvolutionaryTrace; P91127; -.
DR PRO; PR:P91127; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00016321; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR GO; GO:0032273; P:positive regulation of protein polymerization; IBA:GO_Central.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR008907; P25-alpha.
DR PANTHER; PTHR12932; PTHR12932; 1.
DR Pfam; PF05517; p25-alpha; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome.
FT CHAIN 1..180
FT /note="Tubulin polymerization-promoting protein homolog"
FT /evidence="ECO:0000305"
FT /id="PRO_0000221140"
FT REGION 136..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..155
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 11..24
FT /evidence="ECO:0007829|PDB:1PUL"
FT STRAND 27..30
FT /evidence="ECO:0007829|PDB:1PUL"
FT HELIX 34..44
FT /evidence="ECO:0007829|PDB:1PUL"
FT STRAND 49..52
FT /evidence="ECO:0007829|PDB:1PUL"
FT HELIX 54..64
FT /evidence="ECO:0007829|PDB:1PUL"
FT STRAND 67..69
FT /evidence="ECO:0007829|PDB:1PUL"
FT HELIX 73..91
FT /evidence="ECO:0007829|PDB:1PUL"
FT HELIX 95..108
FT /evidence="ECO:0007829|PDB:1PUL"
SQ SEQUENCE 180 AA; 19406 MW; 81C57534B04BD390 CRC64;
MAAAAGFNWD DADVKKRWDA FTKFGAATAT EMTGKNFDKW LKDAGVLDNK AITGTMTGIA
FSKVTGPKKK ATFDETKKVL AFVAEDRARQ SKKPIQDELD AITEKLAKLE APSVGGAAKA
NAAGVYSRLT DHTKYTGAHK ERFDAEGKGK GKSGRADTTE NTGYVGAYKN KDSYDKTHGK
