TPR3_ORYSJ
ID TPR3_ORYSJ Reviewed; 1133 AA.
AC Q10NY2; B9F327;
DT 16-MAR-2016, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Protein TPR3 {ECO:0000303|PubMed:24336200};
DE AltName: Full=Aberrant spikelet and panicle1-related 1 {ECO:0000303|PubMed:22136599};
DE AltName: Full=Protein ASP1-RELATED 1 {ECO:0000303|PubMed:22136599};
DE Short=OsASPR1 {ECO:0000303|PubMed:22136599};
DE AltName: Full=Topless-related protein 1 {ECO:0000303|PubMed:26601214};
DE Short=OsTPR1 {ECO:0000303|PubMed:26601214};
DE AltName: Full=Topless-related protein 3 {ECO:0000303|PubMed:24336200};
GN Name=TPR3 {ECO:0000303|PubMed:24336200};
GN Synonyms=ASPR1 {ECO:0000303|PubMed:22136599},
GN TPR1 {ECO:0000303|PubMed:26601214};
GN OrderedLocusNames=Os03g0254700 {ECO:0000312|EMBL:BAF11501.1},
GN LOC_Os03g14980 {ECO:0000312|EMBL:ABF95023.1};
GN ORFNames=OsJ_08437 {ECO:0000312|EMBL:EEE57834.1};
OS Oryza sativa subsp. japonica (Rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX NCBI_TaxID=39947 {ECO:0000312|EMBL:ABF95023.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], GENE FAMILY, AND NOMENCLATURE.
RX PubMed=22136599; DOI=10.1111/j.1365-313x.2011.04872.x;
RA Yoshida A., Ohmori Y., Kitano H., Taguchi-Shiobara F., Hirano H.;
RT "Aberrant spikelet and panicle1, encoding a TOPLESS-related transcriptional
RT co-repressor, is involved in the regulation of meristem fate in rice.";
RL Plant J. 70:327-339(2012).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16109971; DOI=10.1101/gr.3869505;
RG The rice chromosome 3 sequencing consortium;
RA Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA Jin W., Lee H.R., Jiang J., Jackson S.;
RT "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT and diverged grass species.";
RL Genome Res. 15:1284-1291(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=16100779; DOI=10.1038/nature03895;
RG International rice genome sequencing project (IRGSP);
RT "The map-based sequence of the rice genome.";
RL Nature 436:793-800(2005).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=18089549; DOI=10.1093/nar/gkm978;
RG The rice annotation project (RAP);
RT "The rice annotation project database (RAP-DB): 2008 update.";
RL Nucleic Acids Res. 36:D1028-D1033(2008).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=cv. Nipponbare;
RX PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT "Improvement of the Oryza sativa Nipponbare reference genome using next
RT generation sequence and optical map data.";
RL Rice 6:4-4(2013).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Nipponbare;
RX PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT "The genomes of Oryza sativa: a history of duplications.";
RL PLoS Biol. 3:266-281(2005).
RN [7]
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND GENE FAMILY.
RX PubMed=22020753; DOI=10.1007/s00425-011-1532-7;
RA Gao X., Chen Z., Zhang J., Li X., Chen G., Li X., Wu C.;
RT "OsLIS-L1 encoding a lissencephaly type-1-like protein with WD40 repeats is
RT required for plant height and male gametophyte formation in rice.";
RL Planta 235:713-727(2012).
RN [8]
RP INTERACTION WITH D53, GENE FAMILY, AND NOMENCLATURE.
RX PubMed=24336200; DOI=10.1038/nature12870;
RA Jiang L., Liu X., Xiong G., Liu H., Chen F., Wang L., Meng X., Liu G.,
RA Yu H., Yuan Y., Yi W., Zhao L., Ma H., He Y., Wu Z., Melcher K., Qian Q.,
RA Xu H.E., Wang Y., Li J.;
RT "DWARF 53 acts as a repressor of strigolactone signalling in rice.";
RL Nature 504:401-405(2013).
RN [9]
RP INTERACTION WITH WOX1.
RX PubMed=25697101; DOI=10.1016/j.jgg.2014.12.005;
RA Lu Z., Shao G., Xiong J., Jiao Y., Wang J., Liu G., Meng X., Liang Y.,
RA Xiong G., Wang Y., Li J.;
RT "MONOCULM 3, an ortholog of WUSCHEL in rice, is required for tiller bud
RT formation.";
RL J. Genet. Genomics 42:71-78(2015).
RN [10]
RP NOMENCLATURE.
RX PubMed=26601214; DOI=10.1126/sciadv.1500107;
RA Ke J., Ma H., Gu X., Thelen A., Brunzelle J.S., Li J., Xu H.E., Melcher K.;
RT "Structural basis for recognition of diverse transcriptional repressors by
RT the TOPLESS family of corepressors.";
RL Sci. Adv. 1:E1500107-E1500107(2015).
RN [11]
RP FUNCTION, AND INTERACTION WITH MODD AND HDAC1.
RX PubMed=27468891; DOI=10.1105/tpc.16.00171;
RA Tang N., Ma S., Zong W., Yang N., Lv Y., Yan C., Guo Z., Li J., Li X.,
RA Xiang Y., Song H., Xiao J., Li X., Xiong L.;
RT "MODD mediates deactivation and degradation of OsbZIP46 to negatively
RT regulate ABA signaling and drought resistance in rice.";
RL Plant Cell 28:2161-2177(2016).
RN [12]
RP INTERACTION WITH MOF1.
RX PubMed=32680975; DOI=10.1104/pp.20.00658;
RA Ren D., Rao Y., Yu H., Xu Q., Cui Y., Xia S., Yu X., Liu H., Hu H., Xue D.,
RA Zeng D., Hu J., Zhang G., Gao Z., Zhu L., Zhang Q., Shen L., Guo L.,
RA Qian Q.;
RT "MORE FLORET 1 encodes a MYB transcription factor that regulates spikelet
RT development in rice.";
RL Plant Physiol. 184:251-265(2020).
CC -!- FUNCTION: Probable downstream regulator of strigolactones signaling (By
CC similarity). Functions in a complex with MODD and HDAC1 to down-
CC regulate the histone acetylation level at BZIP46 target genes. BZIP46
CC is a positive regulator of abscisic acid (ABA) signaling and drought
CC stress tolerance (PubMed:27468891). {ECO:0000250|UniProtKB:Q0J7U6,
CC ECO:0000269|PubMed:27468891}.
CC -!- SUBUNIT: Tetramer (PubMed:26601214). Interacts with D53
CC (PubMed:24336200). Interacts with MODD and HDAC1 (PubMed:27468891).
CC Interacts with WOX1 (PubMed:25697101, PubMed:24336200, PubMed:26601214,
CC PubMed:27468891). Interacts with MOF1 (PubMed:32680975).
CC {ECO:0000269|PubMed:24336200, ECO:0000269|PubMed:25697101,
CC ECO:0000269|PubMed:26601214, ECO:0000269|PubMed:27468891,
CC ECO:0000269|PubMed:32680975}.
CC -!- TISSUE SPECIFICITY: Expressed in panicles, stems, leaves, spikelets and
CC seed endosperm. {ECO:0000269|PubMed:22020753}.
CC -!- DEVELOPMENTAL STAGE: Highest expression in endosperm at 21 days after
CC pollination. {ECO:0000269|PubMed:22020753}.
CC -!- DOMAIN: The N-terminal TOPLESS domain (TPD) (1-209) binds directly to a
CC 12-amino acid LxLxL EAR motif peptide. {ECO:0000269|PubMed:26601214}.
CC -!- SEQUENCE CAUTION:
CC Sequence=EEE57834.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB638270; BAL44267.1; -; mRNA.
DR EMBL; DP000009; ABF95023.1; -; Genomic_DNA.
DR EMBL; AP008209; BAF11501.1; -; Genomic_DNA.
DR EMBL; AP014959; BAS83314.1; -; Genomic_DNA.
DR EMBL; CM000139; EEE57834.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_015631118.1; XM_015775632.1.
DR RefSeq; XP_015631120.1; XM_015775634.1.
DR AlphaFoldDB; Q10NY2; -.
DR STRING; 4530.OS03T0254700-01; -.
DR iPTMnet; Q10NY2; -.
DR PaxDb; Q10NY2; -.
DR PRIDE; Q10NY2; -.
DR EnsemblPlants; Os03t0254700-01; Os03t0254700-01; Os03g0254700.
DR GeneID; 4332285; -.
DR Gramene; Os03t0254700-01; Os03t0254700-01; Os03g0254700.
DR KEGG; osa:4332285; -.
DR eggNOG; KOG0266; Eukaryota.
DR HOGENOM; CLU_003103_1_0_1; -.
DR InParanoid; Q10NY2; -.
DR OMA; NMLPMSF; -.
DR OrthoDB; 65958at2759; -.
DR PlantReactome; R-OSA-5632095; Brassinosteroid signaling.
DR PlantReactome; R-OSA-5654828; Strigolactone signaling.
DR Proteomes; UP000000763; Chromosome 3.
DR Proteomes; UP000007752; Chromosome 2.
DR Proteomes; UP000059680; Chromosome 3.
DR ExpressionAtlas; Q10NY2; baseline and differential.
DR GO; GO:0009791; P:post-embryonic development; IEA:UniProt.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0048608; P:reproductive structure development; IEA:UniProt.
DR GO; GO:0048367; P:shoot system development; IEA:UniProt.
DR Gene3D; 2.130.10.10; -; 3.
DR InterPro; IPR006595; CTLH_C.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR027728; Topless_fam.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR44083; PTHR44083; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00668; CTLH; 1.
DR SMART; SM00667; LisH; 1.
DR SMART; SM00320; WD40; 10.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF50998; SSF50998; 1.
DR PROSITE; PS50897; CTLH; 1.
DR PROSITE; PS50896; LISH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 1: Evidence at protein level;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..1133
FT /note="Protein TPR3"
FT /id="PRO_0000435823"
FT DOMAIN 4..36
FT /note="LisH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT DOMAIN 34..92
FT /note="CTLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00058"
FT REPEAT 348..388
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 410..449
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 455..496
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 499..540
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 543..586
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 590..629
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REPEAT 634..673
FT /note="WD 7"
FT /evidence="ECO:0000255"
FT REPEAT 771..810
FT /note="WD 8"
FT /evidence="ECO:0000255"
FT REPEAT 837..875
FT /note="WD 9"
FT /evidence="ECO:0000255"
FT REPEAT 878..918
FT /note="WD 10"
FT /evidence="ECO:0000255"
FT REPEAT 921..960
FT /note="WD 11"
FT /evidence="ECO:0000255"
FT REPEAT 1014..1053
FT /note="WD 12"
FT /evidence="ECO:0000255"
FT REGION 287..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1099..1133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1109..1133
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1133 AA; 125206 MW; E2885BCBA2FA098C CRC64;
MSSLSRELVF LILQFLDEEK FKETVHKLEQ ESGFYFNMKY FEDEVINGNW DEVERYLGGF
TKVDDNRYSM KIFFEIRKQK YLEALDKHDR SKAVEILVKD LKVFASFNEE LFKEITQLLT
LENFRENEQL SKYGDTKSAR AIMLVELKKL IEANPLFRDK LQFPNLKSSR LRTLINQSLN
WQHQLCKNPR PNPDIKTLFV DHSCGQPNGA RAPSPANNPL LGSIPKPGGF PPLGAHAPFQ
PAPTPVPPLA GWMSNPPAVT HPAVSGGAIG FGTPTNPAAI LKHPRTPTTA NPSMDYPSGD
SDHVSKRTRP VGMSEEVNLP VNMLPVTYPQ SHSYPQDDFH KNVARTLSQG STPMSMDFHP
VQQTLLLVGT NVGDIGLWDV GTKERLVLRN FKVWDLTKCS MALQASLVKD PTVSVNRIIW
SPDGTLFGVA YSRHIVQIYS YHGGDDIRQH LEIDAHVGGV NDIAFAHPNK QLCIITCGDD
KTIKVWEATS GAKQFTFEGH EAPVYSVCPH YKENIQFIFS TALDGKIKAW LYDNLGSRVD
YDAPGHWCTT MAYSADGSRL FSCGTSKDGE SHLVEWNESE GAVKRTYQGF RKRSMGVVQF
DTTRNRFLAA GDEFLIKIWD MDNTSLLTTI DADGGLPASP RVRFNKEGTL LAVSTHENGI
KILANADGVR LLRTLENRSF DASRSASETV TKPLMNPLTA AAAAAASAAA AGTSSGNAAP
PAITALNGDS RSLVDVKPRI ADEPLDKSKV WKLMEITESS QCRSLKLTDN MRTSKISRLI
YTNSGVAILA LASNAVHLLW KWPRNDRNSS GKATASVSPQ LWQPPSGILM TNDITDNPEE
AVHCFALSKN DSYVMSASGG KISLFNMMTF KTMTTFMPPP PAATFLAFHP QDNNIIAIGM
DDSTIQIYNV RIDEVKSKLR GHSKKITGLA FSNVLNVLVS SGADAQICVW STDGWDKLKS
RMLQIPSSRP SSIILDTRVQ FHQDQLHFLV VHETQIAIYE TTKLEPVKQW PVRENSSPIT
HAMFSCDSQL IYASFLDATV CIFNASSLRL QCRILPASYL PQNISSNVYP VVVAAHPSEA
NQFALGLTDG GVYVLEPLES ERKWGNPPPA ENGSTSALST PPNGASSSDQ PER
