TPRA1_CAEEL
ID TPRA1_CAEEL Reviewed; 458 AA.
AC Q18936; D3YT19;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Transmembrane protein adipocyte-associated 1 homolog;
GN Name=tpra-1; ORFNames=D1046.5;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-45, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC STRAIN=Bristol N2;
RX PubMed=17761667; DOI=10.1074/mcp.m600392-mcp200;
RA Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T.,
RA Taoka M., Takahashi N., Isobe T.;
RT "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis
RT elegans and suggests an atypical translocation mechanism for integral
RT membrane proteins.";
RL Mol. Cell. Proteomics 6:2100-2109(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a;
CC IsoId=Q18936-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q18936-2; Sequence=VSP_053715;
CC -!- SIMILARITY: Belongs to the UPF0359 family. {ECO:0000305}.
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DR EMBL; Z68160; CAA92293.2; -; Genomic_DNA.
DR EMBL; Z68215; CAA92293.2; JOINED; Genomic_DNA.
DR EMBL; Z68215; CBK19393.1; -; Genomic_DNA.
DR PIR; T20292; T20292.
DR RefSeq; NP_001255357.1; NM_001268428.1. [Q18936-1]
DR RefSeq; NP_001255358.1; NM_001268429.1. [Q18936-2]
DR AlphaFoldDB; Q18936; -.
DR SMR; Q18936; -.
DR STRING; 6239.D1046.5a; -.
DR iPTMnet; Q18936; -.
DR PaxDb; Q18936; -.
DR EnsemblMetazoa; D1046.5a.1; D1046.5a.1; WBGene00008366. [Q18936-1]
DR EnsemblMetazoa; D1046.5b.1; D1046.5b.1; WBGene00008366. [Q18936-2]
DR GeneID; 259586; -.
DR KEGG; cel:CELE_D1046.5; -.
DR UCSC; D1046.5; c. elegans. [Q18936-1]
DR CTD; 259586; -.
DR WormBase; D1046.5a; CE32845; WBGene00008366; tpra-1. [Q18936-1]
DR WormBase; D1046.5b; CE44691; WBGene00008366; tpra-1. [Q18936-2]
DR eggNOG; KOG4536; Eukaryota.
DR GeneTree; ENSGT00390000016807; -.
DR HOGENOM; CLU_702556_0_0_1; -.
DR InParanoid; Q18936; -.
DR OMA; FRIRYWD; -.
DR OrthoDB; 609919at2759; -.
DR PhylomeDB; Q18936; -.
DR PRO; PR:Q18936; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00008366; Expressed in larva and 3 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR018781; TPRA1/CAND2/CAND8.
DR PANTHER; PTHR15876; PTHR15876; 1.
DR Pfam; PF10160; Tmemb_40; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..458
FT /note="Transmembrane protein adipocyte-associated 1
FT homolog"
FT /id="PRO_0000076105"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..134
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 291..311
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 409..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..437
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 45
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:17761667"
FT CARBOHYD 323
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 324
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..395
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_053715"
SQ SEQUENCE 458 AA; 51812 MW; EDF7424A0E853C56 CRC64;
MSVIFHENPG TSLGSVVPDT NTSFERESQL SVKTSPEWID ELFPNVSFID SPTHQVIRGF
CRDVFVYRLP GGFRVRYWDA VILVPNILFL LFLILKCGSV IRKLRTGNSP VLRAFTLLVY
VSTLVNIIRC AYSMTLSMTD GLEQTVDQTL WIIIKFFYLT AEFCALTFGL LFGHLDNGKS
ILIALLGTLL VSIPHTAVQV IIEMKIIDNS WLPLTYFDIQ SDGGFLFWVF SSAVLALVYF
FIMCLPLVCC QKYTKLPSKG SFLIYCMMMV VLNVLQSMGA ALILFKSSDG LCFVGVSTYV
YFVLYPPIIY FTFLRKKLKT PPNNTSGLFM YRKHKDEQGS GDLPDSYYPR FSGLTSPSYD
DLFDYDRDAR FTHYDISRNE YVQNPHYNTY STPLIMTSVE TAESTVTTRT GSDDYAHHRD
SMLSEPSTGT TTRHLKGLGP QGSLVFEDDP SSLTSLRM
