TPRA1_DANRE
ID TPRA1_DANRE Reviewed; 378 AA.
AC Q4V8X0;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Transmembrane protein adipocyte-associated 1 homolog;
DE AltName: Full=Integral membrane protein GPR175;
GN Name=tpra1; Synonyms=gpr175; ORFNames=zgc:114103;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the UPF0359 family. {ECO:0000305}.
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DR EMBL; BC097163; AAH97163.1; -; mRNA.
DR RefSeq; NP_001025422.1; NM_001030251.1.
DR AlphaFoldDB; Q4V8X0; -.
DR STRING; 7955.ENSDARP00000071677; -.
DR PaxDb; Q4V8X0; -.
DR Ensembl; ENSDART00000077209; ENSDARP00000071677; ENSDARG00000054930.
DR GeneID; 570573; -.
DR KEGG; dre:570573; -.
DR CTD; 131601; -.
DR ZFIN; ZDB-GENE-030131-4146; tpra1.
DR eggNOG; KOG4536; Eukaryota.
DR GeneTree; ENSGT00390000016807; -.
DR HOGENOM; CLU_056255_0_0_1; -.
DR InParanoid; Q4V8X0; -.
DR OMA; GGMLFWF; -.
DR OrthoDB; 948626at2759; -.
DR PhylomeDB; Q4V8X0; -.
DR TreeFam; TF314072; -.
DR PRO; PR:Q4V8X0; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 6.
DR Bgee; ENSDARG00000054930; Expressed in spleen and 20 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR InterPro; IPR018781; TPRA1/CAND2/CAND8.
DR PANTHER; PTHR15876; PTHR15876; 1.
DR Pfam; PF10160; Tmemb_40; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..378
FT /note="Transmembrane protein adipocyte-associated 1
FT homolog"
FT /id="PRO_0000076103"
FT TRANSMEM 61..81
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 247..267
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 278..298
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT REGION 316..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 16
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 25
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 36
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 378 AA; 41703 MW; 2125907B6BF41AF7 CRC64;
MLETVTDVAS FVHYGNTSVF PTADNSSEII PDGESNISKP HRCLQVLYDD IGTSRVRYWD
VMLLIPNVAF LVFLMWKLPS ARAKIRLTSS PIFVAFYILV FVVAAVGITR AIVSMTVSTS
SAATLIDKVL WEITRFFLLA IELSVIILGL AFGHLESKSS IKRVLAITAV LSLAYSITQG
TLEIRFPDKH LSAKDFNIYG HGGRHFWLAS SCFFFLVYSL IVILPKTPIR ERISLPSKRS
FYVYSGILAL LNLVQGLGSA LLCADIIEGL CCVDVTTFLY FSVFAPLIYV TFLKGFFGSE
PKILFSYKSQ IDEPEDSDVH LPHTSSSGLG RKDLDRGSYS STQIDGSGAY LDDVVSGPFG
GAHSINSVDS DRWRSINT
