TPRA1_MOUSE
ID TPRA1_MOUSE Reviewed; 369 AA.
AC Q99MU1; Q80UD9; Q8C240; Q91Z36; Q9Z112;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Transmembrane protein adipocyte-associated 1;
DE AltName: Full=Integral membrane protein GPR175;
DE AltName: Full=TPRA40;
DE AltName: Full=Transmembrane domain protein of 40 kDa regulated in adipocytes;
GN Name=Tpra1; Synonyms=Gpr175, Tpra40;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], INDUCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Adipocyte;
RX PubMed=10342878; DOI=10.1210/endo.140.6.6830;
RA Yang H., Egan J.M., Rodgers B.D., Bernier M., Montrose-Rafizadeh C.;
RT "Differential expression of a novel seven transmembrane domain protein in
RT epididymal fat from aged and diabetic mice.";
RL Endocrinology 140:2859-2867(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Lung, and Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 25-148.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Ubiquitous, with higher levels in heart, brain,
CC lung, liver and kidney. {ECO:0000269|PubMed:10342878}.
CC -!- INDUCTION: Induced during adipocytes differentiation and in white fat
CC from aged and diabetics mice. {ECO:0000269|PubMed:10342878}.
CC -!- SIMILARITY: Belongs to the UPF0359 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD15788.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF051098; AAD15788.1; ALT_FRAME; mRNA.
DR EMBL; AK089317; BAC40839.1; -; mRNA.
DR EMBL; AK164913; BAE37962.1; -; mRNA.
DR EMBL; AK172045; BAE42796.1; -; mRNA.
DR EMBL; BC010244; AAH10244.1; -; mRNA.
DR EMBL; BC028977; AAH28977.1; -; mRNA.
DR EMBL; AY255531; AAO85043.1; -; mRNA.
DR CCDS; CCDS39555.1; -.
DR RefSeq; NP_036036.2; NM_011906.2.
DR RefSeq; XP_006506124.1; XM_006506061.2.
DR RefSeq; XP_006506125.1; XM_006506062.2.
DR RefSeq; XP_006506126.1; XM_006506063.2.
DR AlphaFoldDB; Q99MU1; -.
DR STRING; 10090.ENSMUSP00000063042; -.
DR GlyGen; Q99MU1; 2 sites.
DR PhosphoSitePlus; Q99MU1; -.
DR MaxQB; Q99MU1; -.
DR PaxDb; Q99MU1; -.
DR PRIDE; Q99MU1; -.
DR ProteomicsDB; 259504; -.
DR Antibodypedia; 17215; 292 antibodies from 30 providers.
DR Ensembl; ENSMUST00000055022; ENSMUSP00000063042; ENSMUSG00000002871.
DR Ensembl; ENSMUST00000203185; ENSMUSP00000145168; ENSMUSG00000002871.
DR Ensembl; ENSMUST00000204765; ENSMUSP00000145050; ENSMUSG00000002871.
DR GeneID; 24100; -.
DR KEGG; mmu:24100; -.
DR UCSC; uc009cvy.1; mouse.
DR CTD; 131601; -.
DR MGI; MGI:1345190; Tpra1.
DR VEuPathDB; HostDB:ENSMUSG00000002871; -.
DR eggNOG; KOG4536; Eukaryota.
DR GeneTree; ENSGT00390000016807; -.
DR HOGENOM; CLU_056255_0_0_1; -.
DR InParanoid; Q99MU1; -.
DR OMA; GGMLFWF; -.
DR OrthoDB; 948626at2759; -.
DR PhylomeDB; Q99MU1; -.
DR TreeFam; TF314072; -.
DR BioGRID-ORCS; 24100; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Tpra1; mouse.
DR PRO; PR:Q99MU1; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q99MU1; protein.
DR Bgee; ENSMUSG00000002871; Expressed in lip and 247 other tissues.
DR ExpressionAtlas; Q99MU1; baseline and differential.
DR Genevisible; Q99MU1; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0040016; P:embryonic cleavage; IMP:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:1901991; P:negative regulation of mitotic cell cycle phase transition; IMP:MGI.
DR InterPro; IPR018781; TPRA1/CAND2/CAND8.
DR PANTHER; PTHR15876; PTHR15876; 1.
DR Pfam; PF10160; Tmemb_40; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..369
FT /note="Transmembrane protein adipocyte-associated 1"
FT /id="PRO_0000076100"
FT TRANSMEM 45..65
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT CARBOHYD 20
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 329
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 369 AA; 40578 MW; BACB74C431312443 CRC64;
MASLQEANGS TAWPPPTASN ISEPHQCLLL LYEDIGSSRV RYWDLLLLIP NVLFFIFLLW
KLPLARAKIR VTSSPIFITF YILVFVVALV GIARAVVSMT VSASDAATVA DKILWEITRF
FLLAIELSVI ILGLAFGHLE SKSSIKRVLA ITTVLSLAYS VTQGTLEILY PDSHLSAEDF
NIYGHGGRQF WLVSSCFFFL VYSLVVILPK TPLKERVSLP SRRSFYVYAG ILATLNLLQG
LGSALLCANI IVGLCCVDAT TFLYFSFFAP LIYVAFLRGF FGSEPKILFS YKCQVDEAEE
PDMHLPQPYA VARREGIESA GPACASAANY SSTQFDSAGV AYLDDIASMP CHTGSINSTD
SERWKAINA
