TPRA1_RAT
ID TPRA1_RAT Reviewed; 369 AA.
AC Q791F6;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Transmembrane protein adipocyte-associated 1;
DE AltName: Full=Integral membrane protein GPR175;
DE AltName: Full=TPRA40;
DE AltName: Full=Transmembrane domain protein of 40 kDa regulated in adipocytes;
GN Name=Tpra1; Synonyms=Gpr175, Tpra40;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BDIX;
RX PubMed=11267675; DOI=10.1016/s0167-4781(00)00309-2;
RA Fujimoto K., Mizukami Y., Kimura M., Mogami K., Todoroki-Ikeda N.,
RA Kobayashi S., Matsuzaki M.;
RT "Molecular cloning of rat transmembrane domain protein of 40-kDa regulated
RT in adipocytes and its expression in H9c2 cells exposed to ischemic hypoxia
RT and reoxygenation.";
RL Biochim. Biophys. Acta 1518:173-177(2001).
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- INDUCTION: Decreased throughout ischemic hypoxia and reoxygenation.
CC -!- SIMILARITY: Belongs to the UPF0359 family. {ECO:0000305}.
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DR EMBL; AF292116; AAK00287.1; -; mRNA.
DR AlphaFoldDB; Q791F6; -.
DR STRING; 10116.ENSRNOP00000022534; -.
DR GlyGen; Q791F6; 2 sites.
DR PaxDb; Q791F6; -.
DR UCSC; RGD:620858; rat.
DR RGD; 620858; Tpra1.
DR eggNOG; KOG4536; Eukaryota.
DR InParanoid; Q791F6; -.
DR PhylomeDB; Q791F6; -.
DR PRO; PR:Q791F6; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0040016; P:embryonic cleavage; ISO:RGD.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:1901991; P:negative regulation of mitotic cell cycle phase transition; ISO:RGD.
DR InterPro; IPR018781; TPRA1/CAND2/CAND8.
DR PANTHER; PTHR15876; PTHR15876; 1.
DR Pfam; PF10160; Tmemb_40; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..369
FT /note="Transmembrane protein adipocyte-associated 1"
FT /id="PRO_0000076101"
FT TRANSMEM 45..65
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TRANSMEM 73..93
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..209
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TRANSMEM 237..257
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TRANSMEM 262..282
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT CARBOHYD 20
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 329
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 369 AA; 40578 MW; BACB74C431312443 CRC64;
MASLQEANGS TAWPPPTASN ISEPHQCLLL LYEDIGSSRV RYWDLLLLIP NVLFFIFLLW
KLPLARAKIR VTSSPIFITF YILVFVVALV GIARAVVSMT VSASDAATVA DKILWEITRF
FLLAIELSVI ILGLAFGHLE SKSSIKRVLA ITTVLSLAYS VTQGTLEILY PDSHLSAEDF
NIYGHGGRQF WLVSSCFFFL VYSLVVILPK TPLKERVSLP SRRSFYVYAG ILATLNLLQG
LGSALLCANI IVGLCCVDAT TFLYFSFFAP LIYVAFLRGF FGSEPKILFS YKCQVDEAEE
PDMHLPQPYA VARREGIESA GPACASAANY SSTQFDSAGV AYLDDIASMP CHTGSINSTD
SERWKAINA
