TPRG1_HUMAN
ID TPRG1_HUMAN Reviewed; 275 AA.
AC Q6ZUI0;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Tumor protein p63-regulated gene 1 protein;
DE AltName: Full=Protein FAM79B;
GN Name=TPRG1; Synonyms=FAM79B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=18256694; DOI=10.1038/jid.2008.12;
RA Antonini D., Dentice M., Mahtani P., De Rosa L., Della Gatta G.,
RA Mandinova A., Salvatore D., Stupka E., Missero C.;
RT "Tprg, a gene predominantly expressed in skin, is a direct target of the
RT transcription factor p63.";
RL J. Invest. Dermatol. 128:1676-1685(2008).
CC -!- INTERACTION:
CC Q6ZUI0; P02654: APOC1; NbExp=3; IntAct=EBI-17249488, EBI-1220105;
CC Q6ZUI0; P55056: APOC4; NbExp=3; IntAct=EBI-17249488, EBI-18302142;
CC Q6ZUI0; Q13520: AQP6; NbExp=3; IntAct=EBI-17249488, EBI-13059134;
CC Q6ZUI0; Q99675: CGRRF1; NbExp=3; IntAct=EBI-17249488, EBI-2130213;
CC Q6ZUI0; Q9UHD4: CIDEB; NbExp=3; IntAct=EBI-17249488, EBI-7062247;
CC Q6ZUI0; O00559: EBAG9; NbExp=3; IntAct=EBI-17249488, EBI-8787095;
CC Q6ZUI0; Q8NBQ5: HSD17B11; NbExp=3; IntAct=EBI-17249488, EBI-1052304;
CC Q6ZUI0; Q7Z5P4: HSD17B13; NbExp=3; IntAct=EBI-17249488, EBI-18053395;
CC Q6ZUI0; Q5SR56: MFSD14B; NbExp=3; IntAct=EBI-17249488, EBI-373355;
CC Q6ZUI0; Q9H6H4: REEP4; NbExp=3; IntAct=EBI-17249488, EBI-7545592;
CC Q6ZUI0; Q86VR2: RETREG3; NbExp=3; IntAct=EBI-17249488, EBI-10192441;
CC Q6ZUI0; Q6NTF9-3: RHBDD2; NbExp=3; IntAct=EBI-17249488, EBI-17589229;
CC Q6ZUI0; Q9NY72: SCN3B; NbExp=3; IntAct=EBI-17249488, EBI-17247926;
CC Q6ZUI0; Q3KNW5: SLC10A6; NbExp=3; IntAct=EBI-17249488, EBI-18159983;
CC Q6ZUI0; Q9NQQ7-3: SLC35C2; NbExp=3; IntAct=EBI-17249488, EBI-17295964;
CC Q6ZUI0; Q9BXJ8: TMEM120A; NbExp=3; IntAct=EBI-17249488, EBI-727322;
CC Q6ZUI0; Q9Y320: TMX2; NbExp=3; IntAct=EBI-17249488, EBI-6447886;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8CB49}.
CC -!- TISSUE SPECIFICITY: Expressed in the epidermal layer of the skin.
CC {ECO:0000269|PubMed:18256694}.
CC -!- SIMILARITY: Belongs to the TPRG1 family. {ECO:0000305}.
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DR EMBL; AK123232; BAC85565.1; -; mRNA.
DR EMBL; AK125682; BAC86245.1; -; mRNA.
DR EMBL; BC101550; AAI01551.1; -; mRNA.
DR EMBL; BC101552; AAI01553.1; -; mRNA.
DR CCDS; CCDS3292.1; -.
DR RefSeq; NP_940887.1; NM_198485.3.
DR RefSeq; XP_016861750.1; XM_017006261.1.
DR AlphaFoldDB; Q6ZUI0; -.
DR BioGRID; 130099; 28.
DR IntAct; Q6ZUI0; 17.
DR STRING; 9606.ENSP00000341031; -.
DR iPTMnet; Q6ZUI0; -.
DR PhosphoSitePlus; Q6ZUI0; -.
DR BioMuta; TPRG1; -.
DR DMDM; 74711985; -.
DR jPOST; Q6ZUI0; -.
DR MassIVE; Q6ZUI0; -.
DR PaxDb; Q6ZUI0; -.
DR PeptideAtlas; Q6ZUI0; -.
DR PRIDE; Q6ZUI0; -.
DR ProteomicsDB; 68332; -.
DR Antibodypedia; 46848; 47 antibodies from 12 providers.
DR DNASU; 285386; -.
DR Ensembl; ENST00000345063.8; ENSP00000341031.3; ENSG00000188001.10.
DR Ensembl; ENST00000433971.5; ENSP00000412547.1; ENSG00000188001.10.
DR GeneID; 285386; -.
DR KEGG; hsa:285386; -.
DR MANE-Select; ENST00000345063.8; ENSP00000341031.3; NM_198485.4; NP_940887.1.
DR UCSC; uc003frv.3; human.
DR CTD; 285386; -.
DR DisGeNET; 285386; -.
DR GeneCards; TPRG1; -.
DR HGNC; HGNC:24759; TPRG1.
DR HPA; ENSG00000188001; Tissue enhanced (esophagus, vagina).
DR neXtProt; NX_Q6ZUI0; -.
DR OpenTargets; ENSG00000188001; -.
DR PharmGKB; PA162406838; -.
DR VEuPathDB; HostDB:ENSG00000188001; -.
DR eggNOG; ENOG502QSYP; Eukaryota.
DR GeneTree; ENSGT00390000001652; -.
DR HOGENOM; CLU_066718_0_0_1; -.
DR InParanoid; Q6ZUI0; -.
DR OMA; FAFPGMS; -.
DR OrthoDB; 1377646at2759; -.
DR PhylomeDB; Q6ZUI0; -.
DR TreeFam; TF333472; -.
DR PathwayCommons; Q6ZUI0; -.
DR SignaLink; Q6ZUI0; -.
DR BioGRID-ORCS; 285386; 6 hits in 1058 CRISPR screens.
DR ChiTaRS; TPRG1; human.
DR GenomeRNAi; 285386; -.
DR Pharos; Q6ZUI0; Tdark.
DR PRO; PR:Q6ZUI0; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q6ZUI0; protein.
DR Bgee; ENSG00000188001; Expressed in calcaneal tendon and 137 other tissues.
DR ExpressionAtlas; Q6ZUI0; baseline and differential.
DR Genevisible; Q6ZUI0; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR InterPro; IPR034753; hSac2.
DR InterPro; IPR022158; Inositol_phosphatase.
DR InterPro; IPR040242; TPRG1-like.
DR PANTHER; PTHR31108; PTHR31108; 1.
DR Pfam; PF12456; hSac2; 1.
DR PROSITE; PS51791; HSAC2; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..275
FT /note="Tumor protein p63-regulated gene 1 protein"
FT /id="PRO_0000268825"
FT DOMAIN 68..240
FT /note="hSac2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01127"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..39
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 275 AA; 31230 MW; 6306B68136D411E5 CRC64;
MSTIGSFEGF QAVSLKQEGD DQPSETDHLS MEEEDPMPRQ ISRQSSVTES TLYPNPYHQP
YISRKYFATR PGAIETAMED LKGHVAETSG ETIQGFWLLT KIDHWNNEKE RILLVTDKTL
LICKYDFIML SCVQLQRIPL SAVYRICLGK FTFPGMSLDK RQGEGLRIYW GSPEEQSLLS
RWNPWSTEVP YATFTEHPMK YTSEKFLEIC KLSGFMSKLV PAIQNAHKNS TGSGRGKKLM
VLTEPILIET YTGLMSFIGN RNKLGYSLAR GSIGF
