TPRG1_MOUSE
ID TPRG1_MOUSE Reviewed; 279 AA.
AC Q8CB49;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Tumor protein p63-regulated gene 1 protein {ECO:0000305};
DE AltName: Full=Protein FAM79B {ECO:0000250|UniProtKB:Q6ZUI0};
GN Name=Tprg1 {ECO:0000312|MGI:MGI:1918588};
GN Synonyms=Fam79b {ECO:0000250|UniProtKB:Q6ZUI0},
GN Tprg {ECO:0000303|PubMed:18256694};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Vagina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=18256694; DOI=10.1038/jid.2008.12;
RA Antonini D., Dentice M., Mahtani P., De Rosa L., Della Gatta G.,
RA Mandinova A., Salvatore D., Stupka E., Missero C.;
RT "Tprg, a gene predominantly expressed in skin, is a direct target of the
RT transcription factor p63.";
RL J. Invest. Dermatol. 128:1676-1685(2008).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18256694}.
CC -!- TISSUE SPECIFICITY: Highly expressed in skin. Also detected at low
CC levels in tongue and esophagus. {ECO:0000269|PubMed:18256694}.
CC -!- DEVELOPMENTAL STAGE: Detected from embryonic stage 15.5 onwards. At
CC stage 17.5 dpc, detected in epidermis and developing hair follicles.
CC Expression levels in skin increase 4 days after birth and are mainly
CC restricted to differentiated layers of the epidermis.
CC -!- SIMILARITY: Belongs to the TPRG1 family. {ECO:0000305}.
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DR EMBL; AK036796; BAC29579.1; -; mRNA.
DR CCDS; CCDS28084.1; -.
DR RefSeq; NP_780374.1; NM_175165.3.
DR RefSeq; XP_006522644.1; XM_006522581.2.
DR AlphaFoldDB; Q8CB49; -.
DR STRING; 10090.ENSMUSP00000052585; -.
DR PhosphoSitePlus; Q8CB49; -.
DR PaxDb; Q8CB49; -.
DR PRIDE; Q8CB49; -.
DR ProteomicsDB; 259070; -.
DR Antibodypedia; 46848; 47 antibodies from 12 providers.
DR Ensembl; ENSMUST00000056087; ENSMUSP00000052585; ENSMUSG00000048399.
DR GeneID; 71338; -.
DR KEGG; mmu:71338; -.
DR UCSC; uc007yum.1; mouse.
DR CTD; 71338; -.
DR MGI; MGI:1918588; Tprg.
DR VEuPathDB; HostDB:ENSMUSG00000048399; -.
DR eggNOG; ENOG502QSYP; Eukaryota.
DR GeneTree; ENSGT00390000001652; -.
DR HOGENOM; CLU_066718_0_0_1; -.
DR InParanoid; Q8CB49; -.
DR OMA; FAFPGMS; -.
DR OrthoDB; 1377646at2759; -.
DR PhylomeDB; Q8CB49; -.
DR TreeFam; TF333472; -.
DR BioGRID-ORCS; 71338; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Tprg; mouse.
DR PRO; PR:Q8CB49; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q8CB49; protein.
DR Bgee; ENSMUSG00000048399; Expressed in esophagus and 24 other tissues.
DR GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR InterPro; IPR034753; hSac2.
DR InterPro; IPR022158; Inositol_phosphatase.
DR InterPro; IPR040242; TPRG1-like.
DR PANTHER; PTHR31108; PTHR31108; 1.
DR Pfam; PF12456; hSac2; 1.
DR PROSITE; PS51791; HSAC2; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..279
FT /note="Tumor protein p63-regulated gene 1 protein"
FT /id="PRO_0000268826"
FT DOMAIN 72..259
FT /note="hSac2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01127"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 279 AA; 31269 MW; E3CAF36B38E65464 CRC64;
MSTIGSFDGF QPVSLKQEEE DQPSENDHLS TKEGNSGKDP GSRRISRQQS ITKATLYPNP
YRQPYVSRKY FVTRPGAIET AVEDLKGHIA QTSGETVQGF WLLTEIDHWN NEKEKILLLT
DKTLLICKYD FIMLSCVQVQ QVPLNAICCI CLGKFVFPGM SLDKRPGDGL RIFWGSTEGW
SLLSRWNPWS TEVPYATFTE HPMKQTSEKF LEICKLSEFT SKLVPAIENA HKNSAGSGSG
KELVVLTQPI LIETYTGLMS FIGNRNKLGY SLARGSIGF
