ID   TPRGL_BOVIN             Reviewed;         275 AA.
AC   Q32LJ4; A5D9I0;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2017, sequence version 2.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Tumor protein p63-regulated gene 1-like protein;
DE   AltName: Full=Mossy fiber terminal-associated vertebrate-specific presynaptic protein;
DE   AltName: Full=Protein FAM79A;
GN   Name=TPRG1L; Synonyms=FAM79A, MOVER;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Abomasum {ECO:0000312|EMBL:ABQ13039.1};
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=Crossbred X Angus; TISSUE=Liver {ECO:0000312|EMBL:AAI09548.1};
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Presynaptic protein involved in the synaptic transmission
CC       tuning. Regulates synaptic release probability by decreasing the
CC       calcium sensitivity of release. {ECO:0000250|UniProtKB:A8WCF8}.
CC   -!- SUBUNIT: Forms homomultimers. Multimerization appears to be important
CC       for presynaptic targeting. Interacts with BSN.
CC       {ECO:0000250|UniProtKB:A8WCF8, ECO:0000250|UniProtKB:Q9DBS2}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic
CC       vesicle membrane {ECO:0000250|UniProtKB:A8WCF8}; Peripheral membrane
CC       protein {ECO:0000250|UniProtKB:A8WCF8}. Presynaptic active zone
CC       {ECO:0000250|UniProtKB:A8WCF8}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q32LJ4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q32LJ4-2; Sequence=VSP_058919;
CC   -!- PTM: Phosphorylated. Phosphorylation promotes association with synaptic
CC       vesicle membranes. {ECO:0000250|UniProtKB:A8WCF8}.
CC   -!- SIMILARITY: Belongs to the TPRG1 family. {ECO:0000305}.
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DR   EMBL; BT030599; ABQ13039.1; -; mRNA.
DR   EMBL; BC109547; AAI09548.1; -; mRNA.
DR   RefSeq; NP_001069886.2; NM_001076418.2. [Q32LJ4-1]
DR   AlphaFoldDB; Q32LJ4; -.
DR   STRING; 9913.ENSBTAP00000021078; -.
DR   PaxDb; Q32LJ4; -.
DR   PRIDE; Q32LJ4; -.
DR   GeneID; 616333; -.
DR   KEGG; bta:616333; -.
DR   CTD; 127262; -.
DR   eggNOG; ENOG502QTYQ; Eukaryota.
DR   InParanoid; Q32LJ4; -.
DR   OrthoDB; 1377646at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0044305; C:calyx of Held; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0048786; C:presynaptic active zone; IEA:UniProtKB-SubCell.
DR   GO; GO:0008021; C:synaptic vesicle; ISS:UniProtKB.
DR   GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0051966; P:regulation of synaptic transmission, glutamatergic; ISS:UniProtKB.
DR   InterPro; IPR034753; hSac2.
DR   InterPro; IPR022158; Inositol_phosphatase.
DR   InterPro; IPR040242; TPRG1-like.
DR   PANTHER; PTHR31108; PTHR31108; 1.
DR   Pfam; PF12456; hSac2; 1.
DR   PROSITE; PS51791; HSAC2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell projection; Cytoplasmic vesicle; Membrane;
KW   Phosphoprotein; Reference proteome; Synapse.
FT   CHAIN           1..275
FT                   /note="Tumor protein p63-regulated gene 1-like protein"
FT                   /id="PRO_0000269185"
FT   DOMAIN          68..240
FT                   /note="hSac2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01127"
FT   REGION          21..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          61..100
FT                   /note="Important for homomultimer formation and
FT                   localization to presynaptic regions"
FT                   /evidence="ECO:0000250|UniProtKB:A8WCF8"
FT   REGION          189..275
FT                   /note="Important for homomultimer formation"
FT                   /evidence="ECO:0000250|UniProtKB:A8WCF8"
FT   MOD_RES         10
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9DBS2"
FT   MOD_RES         14
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:A8WCF8"
FT   MOD_RES         43
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5T0D9"
FT   VAR_SEQ         25..70
FT                   /note="Missing (in isoform 2)"
FT                   /id="VSP_058919"
SQ   SEQUENCE   275 AA;  30303 MW;  C9396A89CF75A175 CRC64;
     MLQLRDSVDS AGTSPTALLA AGEEVGPGSG GGGGGGGRPG VGTPLRQTLW PLSVHDPTRR
     ARVKEYFVFR PGTIEQAVEE IRVVVRPVED GDIQGVWLLT EVDHWNNEKE RLVLITDQAL
     LICKYDFISL QCQQVVRVAL NAVDTISYGE FQFPPKSLNK REGFGIRIQW DKQSRPSFIS
     RWNPWSTSVP YTTFIEHPMA GVDEKTASLC QLDGFKALLI QAVKKAQKES PLPGQEGGVL
     VLECPLLIET YVGLMSFINN EAKLGYSMTR GKIGF