TPRN_HUMAN
ID TPRN_HUMAN Reviewed; 711 AA.
AC Q4KMQ1; B7ZKU5; Q5VSG5; Q5VSG6; Q6IPP2; Q8NCH2;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Taperin;
GN Name=TPRN; Synonyms=C9orf75;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 189-711 (ISOFORM 1).
RC TISSUE=Brain, and Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT networks.";
RL Cell 127:635-648(2006).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP INVOLVEMENT IN DFNB79.
RX PubMed=20170899; DOI=10.1016/j.ajhg.2010.01.030;
RA Rehman A.U., Morell R.J., Belyantseva I.A., Khan S.Y., Boger E.T.,
RA Shahzad M., Ahmed Z.M., Riazuddin S., Khan S.N., Riazuddin S.,
RA Friedman T.B.;
RT "Targeted capture and next-generation sequencing identifies C9orf75,
RT encoding taperin, as the mutated gene in nonsyndromic deafness DFNB79.";
RL Am. J. Hum. Genet. 86:378-388(2010).
RN [7]
RP TISSUE SPECIFICITY, AND INVOLVEMENT IN DFNB79.
RX PubMed=20170898; DOI=10.1016/j.ajhg.2010.02.003;
RA Li Y., Pohl E., Boulouiz R., Schraders M., Nurnberg G., Charif M.,
RA Admiraal R.J., von Ameln S., Baessmann I., Kandil M., Veltman J.A.,
RA Nurnberg P., Kubisch C., Barakat A., Kremer H., Wollnik B.;
RT "Mutations in TPRN cause a progressive form of autosomal-recessive
RT nonsyndromic hearing loss.";
RL Am. J. Hum. Genet. 86:479-484(2010).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-241 AND SER-362, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q4KMQ1; P62136: PPP1CA; NbExp=3; IntAct=EBI-3942777, EBI-357253;
CC Q4KMQ1-2; O00299: CLIC1; NbExp=8; IntAct=EBI-11978969, EBI-347404;
CC Q4KMQ1-2; O15247: CLIC2; NbExp=3; IntAct=EBI-11978969, EBI-6286019;
CC Q4KMQ1-2; Q9Y696: CLIC4; NbExp=4; IntAct=EBI-11978969, EBI-1057480;
CC Q4KMQ1-2; Q9NZA1-2: CLIC5; NbExp=6; IntAct=EBI-11978969, EBI-13076412;
CC Q4KMQ1-2; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-11978969, EBI-14103818;
CC Q4KMQ1-2; P62136: PPP1CA; NbExp=6; IntAct=EBI-11978969, EBI-357253;
CC Q4KMQ1-2; P36873: PPP1CC; NbExp=3; IntAct=EBI-11978969, EBI-356283;
CC Q4KMQ1-2; Q9P202: WHRN; NbExp=7; IntAct=EBI-11978969, EBI-310886;
CC -!- SUBCELLULAR LOCATION: Cell projection, stereocilium {ECO:0000250}.
CC Note=Localized prominently at the taper regions of hair cell
CC stereocilia. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q4KMQ1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q4KMQ1-2; Sequence=VSP_033027;
CC Name=3;
CC IsoId=Q4KMQ1-3; Sequence=VSP_033027, VSP_033028;
CC Name=4;
CC IsoId=Q4KMQ1-4; Sequence=VSP_039038, VSP_039039;
CC -!- TISSUE SPECIFICITY: Expression is detected in fetal cochlea.
CC {ECO:0000269|PubMed:20170898}.
CC -!- DISEASE: Deafness, autosomal recessive, 79 (DFNB79) [MIM:613307]: A
CC form of non-syndromic deafness characterized by progressive and severe
CC sensorineural hearing loss. There are no symptoms of vestibular
CC dysfunction. {ECO:0000269|PubMed:20170898,
CC ECO:0000269|PubMed:20170899}. Note=The disease is caused by variants
CC affecting the gene represented in this entry.
CC -!- SIMILARITY: Belongs to the taperin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAI11501.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK074735; BAC11169.1; -; mRNA.
DR EMBL; AL929554; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC071831; AAH71831.1; -; mRNA.
DR EMBL; BC098411; AAH98411.1; -; mRNA.
DR EMBL; BC111500; AAI11501.1; ALT_INIT; mRNA.
DR EMBL; BC128601; AAI28602.1; -; mRNA.
DR EMBL; BC143385; AAI43386.1; -; mRNA.
DR CCDS; CCDS56594.1; -. [Q4KMQ1-1]
DR RefSeq; NP_001121700.2; NM_001128228.2. [Q4KMQ1-1]
DR PDB; 6Y9Q; X-ray; 1.31 A; D=452-468.
DR PDBsum; 6Y9Q; -.
DR AlphaFoldDB; Q4KMQ1; -.
DR SMR; Q4KMQ1; -.
DR BioGRID; 130345; 57.
DR IntAct; Q4KMQ1; 41.
DR MINT; Q4KMQ1; -.
DR STRING; 9606.ENSP00000387100; -.
DR GlyGen; Q4KMQ1; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q4KMQ1; -.
DR PhosphoSitePlus; Q4KMQ1; -.
DR BioMuta; TPRN; -.
DR DMDM; 187470857; -.
DR EPD; Q4KMQ1; -.
DR jPOST; Q4KMQ1; -.
DR MassIVE; Q4KMQ1; -.
DR MaxQB; Q4KMQ1; -.
DR PaxDb; Q4KMQ1; -.
DR PeptideAtlas; Q4KMQ1; -.
DR PRIDE; Q4KMQ1; -.
DR ProteomicsDB; 62199; -. [Q4KMQ1-1]
DR ProteomicsDB; 62200; -. [Q4KMQ1-2]
DR ProteomicsDB; 62201; -. [Q4KMQ1-3]
DR ProteomicsDB; 62202; -. [Q4KMQ1-4]
DR Antibodypedia; 18953; 40 antibodies from 13 providers.
DR DNASU; 286262; -.
DR Ensembl; ENST00000409012.6; ENSP00000387100.4; ENSG00000176058.13. [Q4KMQ1-1]
DR GeneID; 286262; -.
DR KEGG; hsa:286262; -.
DR MANE-Select; ENST00000409012.6; ENSP00000387100.4; NM_001128228.3; NP_001121700.2.
DR UCSC; uc004clu.4; human. [Q4KMQ1-1]
DR CTD; 286262; -.
DR DisGeNET; 286262; -.
DR GeneCards; TPRN; -.
DR HGNC; HGNC:26894; TPRN.
DR HPA; ENSG00000176058; Tissue enhanced (brain, pancreas).
DR MalaCards; TPRN; -.
DR MIM; 613307; phenotype.
DR MIM; 613354; gene.
DR neXtProt; NX_Q4KMQ1; -.
DR OpenTargets; ENSG00000176058; -.
DR Orphanet; 90636; Autosomal recessive non-syndromic sensorineural deafness type DFNB.
DR PharmGKB; PA165586341; -.
DR VEuPathDB; HostDB:ENSG00000176058; -.
DR eggNOG; ENOG502RHCM; Eukaryota.
DR GeneTree; ENSGT00530000064035; -.
DR HOGENOM; CLU_023685_1_0_1; -.
DR InParanoid; Q4KMQ1; -.
DR OMA; KAKVPCS; -.
DR OrthoDB; 732540at2759; -.
DR PhylomeDB; Q4KMQ1; -.
DR TreeFam; TF333324; -.
DR PathwayCommons; Q4KMQ1; -.
DR Reactome; R-HSA-9662360; Sensory processing of sound by inner hair cells of the cochlea.
DR Reactome; R-HSA-9662361; Sensory processing of sound by outer hair cells of the cochlea.
DR SignaLink; Q4KMQ1; -.
DR BioGRID-ORCS; 286262; 12 hits in 1075 CRISPR screens.
DR ChiTaRS; TPRN; human.
DR GenomeRNAi; 286262; -.
DR Pharos; Q4KMQ1; Tbio.
DR PRO; PR:Q4KMQ1; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q4KMQ1; protein.
DR Bgee; ENSG00000176058; Expressed in mucosa of transverse colon and 139 other tissues.
DR ExpressionAtlas; Q4KMQ1; baseline and differential.
DR Genevisible; Q4KMQ1; HS.
DR GO; GO:0032420; C:stereocilium; ISS:UniProtKB.
DR GO; GO:0120044; C:stereocilium base; IBA:GO_Central.
DR GO; GO:0019902; F:phosphatase binding; IEA:InterPro.
DR GO; GO:0060088; P:auditory receptor cell stereocilium organization; IBA:GO_Central.
DR GO; GO:0007605; P:sensory perception of sound; IMP:UniProtKB.
DR GO; GO:0120045; P:stereocilium maintenance; IBA:GO_Central.
DR InterPro; IPR025903; Phostensin/Taperin_N_dom.
DR InterPro; IPR025907; Phostensin/Taperin_PP1-bd_dom.
DR InterPro; IPR026671; PPP1R18/Tprn.
DR InterPro; IPR033359; TPRN.
DR PANTHER; PTHR21685; PTHR21685; 1.
DR PANTHER; PTHR21685:SF1; PTHR21685:SF1; 1.
DR Pfam; PF13914; Phostensin; 1.
DR Pfam; PF13916; Phostensin_N; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Cell projection; Deafness; Hearing;
KW Non-syndromic deafness; Phosphoprotein; Reference proteome.
FT CHAIN 1..711
FT /note="Taperin"
FT /id="PRO_0000330309"
FT REGION 134..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..535
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 572..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 642..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..183
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 256..275
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..535
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..624
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 241
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 362
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 418
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A2AI08"
FT MOD_RES 463
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A2AI08"
FT VAR_SEQ 1..306
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_033027"
FT VAR_SEQ 1..305
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_039038"
FT VAR_SEQ 306..311
FT /note="VMETIP -> MVSITG (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_039039"
FT VAR_SEQ 691
FT /note="M -> MVRCGGVERWGESDTRASPCVHILSSHFQ (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_033028"
FT CONFLICT 338
FT /note="K -> N (in Ref. 1; BAC11169)"
FT /evidence="ECO:0000305"
FT STRAND 455..457
FT /evidence="ECO:0007829|PDB:6Y9Q"
FT HELIX 458..460
FT /evidence="ECO:0007829|PDB:6Y9Q"
SQ SEQUENCE 711 AA; 75556 MW; B85D155DF1DD2147 CRC64;
MAALGRPGSG PRAAVPAWKR EILERKRAKL AALGGGAGPG AAEPEQRVLA ESLGPLRENP
FMLLEAERRR GGGAAGARLL ERYRRVPGVR ALRADSVLII ETVPGFPPAP PAPGAAQIRA
AEVLVYGAPP GRVSRLLERF DPPAAPRRRG SPERARPPPP PPPPAPPRPP PAAPSPPAAP
GPRGGGASPG ARRSDFLQKT GSNSFTVHPR GLHRGAGARL LSNGHSAPEP RAGPANRLAG
SPPGSGQWKP KVESGDPSLH PPPSPGTPSA TPASPPASAT PSQRQCVSAA TSTNDSFEIR
PAPKPVMETI PLGDLQARAL ASLRANSRNS FMVIPKSKAS GAPPPEGRQS VELPKGDLGP
ASPSQELGSQ PVPGGDGAPA LGKSPLEVEA QWAVEEGACP RTATALADRA IRWQRPSSPP
PFLPAASEEA EPAEGLRVPG LAKNSREYVR PGLPVTFIDE VDSEEAPQAA KLPYLPHPAR
PLHPARPGCV AELQPRGSNT FTVVPKRKPG TLQDQHFSQA NREPRPREAE EEEASCLLGP
TLKKRYPTVH EIEVIGGYLA LQKSCLTKAG SSRKKMKISF NDKSLQTTFE YPSESSLEQE
EEVDQQEEEE EEEEEEEEEE EGSGSEEKPF ALFLPRATFV SSVRPESSRL PEGSSGLSSY
TPKHSVAFSK WQEQALEQAP REAEPPPVEA MLTPASQNDL SDFRSEPALY F
