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TPRN_MOUSE
ID   TPRN_MOUSE              Reviewed;         749 AA.
AC   A2AI08; Q3TAJ8; Q3TMR8; Q5FWB3; Q7TNG3; Q8BNM5; Q8R1G4;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Taperin;
GN   Name=Tprn;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J, and NOD; TISSUE=Diencephalon;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 135-749.
RC   STRAIN=FVB/N; TISSUE=Brain, and Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-457 AND SER-501, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA   Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA   Thibault P.;
RT   "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL   Immunity 30:143-154(2009).
RN   [5]
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=20170899; DOI=10.1016/j.ajhg.2010.01.030;
RA   Rehman A.U., Morell R.J., Belyantseva I.A., Khan S.Y., Boger E.T.,
RA   Shahzad M., Ahmed Z.M., Riazuddin S., Khan S.N., Riazuddin S.,
RA   Friedman T.B.;
RT   "Targeted capture and next-generation sequencing identifies C9orf75,
RT   encoding taperin, as the mutated gene in nonsyndromic deafness DFNB79.";
RL   Am. J. Hum. Genet. 86:378-388(2010).
RN   [6]
RP   TISSUE SPECIFICITY.
RX   PubMed=20170898; DOI=10.1016/j.ajhg.2010.02.003;
RA   Li Y., Pohl E., Boulouiz R., Schraders M., Nurnberg G., Charif M.,
RA   Admiraal R.J., von Ameln S., Baessmann I., Kandil M., Veltman J.A.,
RA   Nurnberg P., Kubisch C., Barakat A., Kremer H., Wollnik B.;
RT   "Mutations in TPRN cause a progressive form of autosomal-recessive
RT   nonsyndromic hearing loss.";
RL   Am. J. Hum. Genet. 86:479-484(2010).
RN   [7]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-457 AND SER-501, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Kidney, Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBCELLULAR LOCATION: Cell projection, stereocilium
CC       {ECO:0000269|PubMed:20170899}. Note=Localized prominently at the taper
CC       regions of hair cell stereocilia.
CC   -!- TISSUE SPECIFICITY: Expressed in the sensory epithelia of the organ of
CC       Corti and vestibular end organs and, to a lesser extent, in Reisner's
CC       membrane and the spiral ligament (at protein level). At postnatal day
CC       2, expression is detected in cochlea, liver, brain, kidney, heart and
CC       lung. {ECO:0000269|PubMed:20170898, ECO:0000269|PubMed:20170899}.
CC   -!- SIMILARITY: Belongs to the taperin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH89508.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAC38669.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAC38669.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=BAE38373.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAE42670.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=BAE42670.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AK082888; BAC38669.1; ALT_SEQ; mRNA.
DR   EMBL; AK165772; BAE38373.1; ALT_INIT; mRNA.
DR   EMBL; AK171799; BAE42670.1; ALT_SEQ; mRNA.
DR   EMBL; AL732309; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC024573; AAH24573.1; -; mRNA.
DR   EMBL; BC055478; AAH55478.1; -; mRNA.
DR   EMBL; BC089508; AAH89508.1; ALT_INIT; mRNA.
DR   CCDS; CCDS15759.2; -.
DR   RefSeq; NP_780495.2; NM_175286.4.
DR   AlphaFoldDB; A2AI08; -.
DR   STRING; 10090.ENSMUSP00000109975; -.
DR   iPTMnet; A2AI08; -.
DR   PhosphoSitePlus; A2AI08; -.
DR   EPD; A2AI08; -.
DR   MaxQB; A2AI08; -.
DR   PaxDb; A2AI08; -.
DR   PeptideAtlas; A2AI08; -.
DR   PRIDE; A2AI08; -.
DR   ProteomicsDB; 259072; -.
DR   Antibodypedia; 18953; 40 antibodies from 13 providers.
DR   Ensembl; ENSMUST00000114336; ENSMUSP00000109975; ENSMUSG00000048707.
DR   GeneID; 97031; -.
DR   KEGG; mmu:97031; -.
DR   UCSC; uc008ira.2; mouse.
DR   CTD; 286262; -.
DR   MGI; MGI:2139535; Tprn.
DR   VEuPathDB; HostDB:ENSMUSG00000048707; -.
DR   eggNOG; ENOG502RHCM; Eukaryota.
DR   GeneTree; ENSGT00530000064035; -.
DR   HOGENOM; CLU_023685_1_0_1; -.
DR   InParanoid; A2AI08; -.
DR   OMA; KAKVPCS; -.
DR   OrthoDB; 732540at2759; -.
DR   PhylomeDB; A2AI08; -.
DR   TreeFam; TF333324; -.
DR   BioGRID-ORCS; 97031; 1 hit in 73 CRISPR screens.
DR   PRO; PR:A2AI08; -.
DR   Proteomes; UP000000589; Chromosome 2.
DR   RNAct; A2AI08; protein.
DR   Bgee; ENSMUSG00000048707; Expressed in seminiferous tubule of testis and 148 other tissues.
DR   Genevisible; A2AI08; MM.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0032420; C:stereocilium; IDA:UniProtKB.
DR   GO; GO:0120044; C:stereocilium base; IDA:MGI.
DR   GO; GO:0019902; F:phosphatase binding; IEA:InterPro.
DR   GO; GO:0060088; P:auditory receptor cell stereocilium organization; IGI:MGI.
DR   GO; GO:0007605; P:sensory perception of sound; IMP:MGI.
DR   GO; GO:0120045; P:stereocilium maintenance; IMP:MGI.
DR   InterPro; IPR025903; Phostensin/Taperin_N_dom.
DR   InterPro; IPR025907; Phostensin/Taperin_PP1-bd_dom.
DR   InterPro; IPR026671; PPP1R18/Tprn.
DR   InterPro; IPR033359; TPRN.
DR   PANTHER; PTHR21685; PTHR21685; 1.
DR   PANTHER; PTHR21685:SF1; PTHR21685:SF1; 1.
DR   Pfam; PF13914; Phostensin; 1.
DR   Pfam; PF13916; Phostensin_N; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Hearing; Phosphoprotein; Reference proteome.
FT   CHAIN           1..749
FT                   /note="Taperin"
FT                   /id="PRO_0000330310"
FT   REGION          144..348
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          502..586
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          636..673
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          730..749
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        167..184
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        249..270
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        290..316
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        317..339
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        534..548
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        555..586
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        644..667
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         274
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q4KMQ1"
FT   MOD_RES         401
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q4KMQ1"
FT   MOD_RES         457
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:19144319,
FT                   ECO:0007744|PubMed:21183079"
FT   MOD_RES         501
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:19144319,
FT                   ECO:0007744|PubMed:21183079"
FT   CONFLICT        264
FT                   /note="P -> T (in Ref. 1; BAE38373)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        265
FT                   /note="T -> A (in Ref. 1; BAE42670)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        432
FT                   /note="A -> V (in Ref. 1; BAE42670)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        527
FT                   /note="A -> D (in Ref. 1; BAE42670)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        531..532
FT                   /note="HT -> DN (in Ref. 1; BAE42670)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        650
FT                   /note="Missing (in Ref. 1; BAE42670)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        671
FT                   /note="E -> G (in Ref. 3; AAH89508)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   749 AA;  80089 MW;  02E3D12D60051082 CRC64;
     MAGLGRLDPG PRTVMPAWKR EILERRRAKL AALSGGQGSG AAPDGPNERL VLAESLGPLS
     QNPFMRLESE RRRGTRPAQQ LLELYCRVPG VRTIRADNIL IIESAPGFPP AVPPAAGIRA
     AEVVVYEAPQ PGRVSRLLEK FDSPAAPCRR GSPERFRPAL PQLPVASASA ATRTPTNRSL
     APASPVRLSQ PAPPISPVPV AQRAGQRSAC CEPAHPDGTA GPGARRSDFL QKTGSNSFTV
     HPRGLPRSAV NRSLSNGPMT QESPTGPANG LSGSPPVPGK WKPKVESKEP SLHPPPSPGT
     PSATSVGPPA FPAPSPASAT PSQRQWVSSA TSANDSFEIR PSSKPDMETI PIGDLQARAL
     ANLRVNSRNS FVLIPKRKAP GNYPLAGRQF EEPKGEVGWA SQSQGLGSQL VSTVDGAPAL
     EKSPLAAEMQ WAVRKGACPR PAISDTDKCV RWQRPASPPP FLPATAEAEP AEGLGVPGLA
     KNGQEPVRPG LPVTFIDEVD SEEEAFQEAK LPSSAVGVPS QYHLHPARPG HTSELLNRGS
     NTFTVVPKRK PGTLQEPHLS QTNGQSQQGA EEQDAESLSG PHTTLENTLK KRYPTVHEIE
     VIGGYLALQK SCLIKAGSSR KKMKISFNDK SLHTTFEYPS ESSLAQEEAE EEEEEEGEED
     GEEEEVGPDS EKPFTVFLPR ATFVSSVGPE SSSGLSSYTP KHSMAFSKWQ EQTLVQTPTD
     VELPPKEVML TPASQNDLSD FRSEPALYF
 
 
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