TPRN_RAT
ID TPRN_RAT Reviewed; 753 AA.
AC Q5XHX2;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Taperin;
GN Name=Tprn;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 223-753.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-274 AND SER-458, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- SUBCELLULAR LOCATION: Cell projection, stereocilium {ECO:0000250}.
CC Note=Localized prominently at the taper regions of hair cell
CC stereocilia. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the taperin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH83928.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AABR03024111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC083928; AAH83928.1; ALT_INIT; mRNA.
DR RefSeq; NP_001019480.2; NM_001024309.2.
DR AlphaFoldDB; Q5XHX2; -.
DR STRING; 10116.ENSRNOP00000014489; -.
DR iPTMnet; Q5XHX2; -.
DR PhosphoSitePlus; Q5XHX2; -.
DR PaxDb; Q5XHX2; -.
DR PRIDE; Q5XHX2; -.
DR Ensembl; ENSRNOT00000014489; ENSRNOP00000014489; ENSRNOG00000010896.
DR GeneID; 499749; -.
DR KEGG; rno:499749; -.
DR UCSC; RGD:1562935; rat.
DR CTD; 286262; -.
DR RGD; 1562935; Tprn.
DR eggNOG; ENOG502RHCM; Eukaryota.
DR GeneTree; ENSGT00530000064035; -.
DR HOGENOM; CLU_023685_1_0_1; -.
DR InParanoid; Q5XHX2; -.
DR OMA; KAKVPCS; -.
DR OrthoDB; 732540at2759; -.
DR PhylomeDB; Q5XHX2; -.
DR TreeFam; TF333324; -.
DR PRO; PR:Q5XHX2; -.
DR Proteomes; UP000002494; Chromosome 3.
DR Bgee; ENSRNOG00000010896; Expressed in testis and 19 other tissues.
DR Genevisible; Q5XHX2; RN.
DR GO; GO:0032420; C:stereocilium; ISS:UniProtKB.
DR GO; GO:0120044; C:stereocilium base; ISO:RGD.
DR GO; GO:0019902; F:phosphatase binding; IEA:InterPro.
DR GO; GO:0060088; P:auditory receptor cell stereocilium organization; ISO:RGD.
DR GO; GO:0007605; P:sensory perception of sound; ISS:UniProtKB.
DR GO; GO:0120045; P:stereocilium maintenance; ISO:RGD.
DR InterPro; IPR025903; Phostensin/Taperin_N_dom.
DR InterPro; IPR025907; Phostensin/Taperin_PP1-bd_dom.
DR InterPro; IPR026671; PPP1R18/Tprn.
DR InterPro; IPR033359; TPRN.
DR PANTHER; PTHR21685; PTHR21685; 1.
DR PANTHER; PTHR21685:SF1; PTHR21685:SF1; 1.
DR Pfam; PF13914; Phostensin; 1.
DR Pfam; PF13916; Phostensin_N; 1.
PE 1: Evidence at protein level;
KW Cell projection; Hearing; Phosphoprotein; Reference proteome.
FT CHAIN 1..753
FT /note="Taperin"
FT /id="PRO_0000330311"
FT REGION 141..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 544..583
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..198
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..315
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 316..339
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..583
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 645..671
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 274
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 402
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q4KMQ1"
FT MOD_RES 458
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
FT MOD_RES 502
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:A2AI08"
SQ SEQUENCE 753 AA; 80272 MW; 9E754FCBA2FB582A CRC64;
MAGLGRLDPG PRTVMPAWKR EILERRRAKL AALSGGPGSG AAPDGPNERL VLAESLGPLS
QNPFMRLESE RRRGARPAQQ LLELYCRVPG VRTIRADNIL IIESAPGFPP AVPPASSIRA
AEVVVYEEPQ PGRVSRLLEK FDSPAAPRRR GSPERFRPAL PQLPVAPASA ATRAPTNRSL
APAPPVLPSQ PAPPISPVPV AQRAGQRSAC CEPAHPDGTA GPGARRSDFL QKTGSNSFTV
HPRGLPGSAV NRSLSNGPMT QESPAGPANG LSGSPPVPGK WKPKVESKEP SLHPPPSPGT
PSATPVGPPA FLAPSPASAT PSQRQWVSSA TSANDSFEIR PSSKPDMETI PIGDLQARAL
ANLRVNSRNS FVLIPKRKAP GNYPSAAGRQ FEEPKGEVGW ASQSQGLGSQ LVSTVDGAPA
LEKSSLAAEM QWAVREGGCP RPAISDTDKS VRRQRPASPP PFLPATTEAE PAEGLGVPGL
TKNGQEPVRP GLPVTFIDEV DSEEAAFQEA KLPSSAVGVP SQYHLHPSTP GHTSELLNRG
SNTFTVVPKR KPGTLQEPHL SQTNGQFQQG AEEQDADSLS GPHTTLENAL KKRYPTVNEI
EVIGGYLALQ KSCLIKAGSS RKKMKISFND KSLHTTFEYP SESSLAQEEA EEEEEEEEEE
EGEDGEEEEV GPDSEKSFTV LLPRATFVSS VGPESSSGLS SYTPKHSMAF SKWQEQTLVQ
APTEVELPPK EVMLTPASQN DLSDFRSEPA LYF
