TPRX1_HUMAN
ID TPRX1_HUMAN Reviewed; 411 AA.
AC Q8N7U7; A5D8Y3; B2RPL5;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 3.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Tetra-peptide repeat homeobox protein 1 {ECO:0000305};
GN Name=TPRX1 {ECO:0000312|HGNC:HGNC:32174};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N7U7-2; P54253: ATXN1; NbExp=3; IntAct=EBI-14115717, EBI-930964;
CC Q8N7U7-2; O15287: FANCG; NbExp=3; IntAct=EBI-14115717, EBI-81610;
CC Q8N7U7-2; Q08379: GOLGA2; NbExp=3; IntAct=EBI-14115717, EBI-618309;
CC Q8N7U7-2; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-14115717, EBI-5916454;
CC Q8N7U7-2; Q0VD86: INCA1; NbExp=3; IntAct=EBI-14115717, EBI-6509505;
CC Q8N7U7-2; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-14115717, EBI-10241353;
CC Q8N7U7-2; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-14115717, EBI-11962084;
CC Q8N7U7-2; Q13064: MKRN3; NbExp=3; IntAct=EBI-14115717, EBI-2340269;
CC Q8N7U7-2; Q8WX92-2: NELFB; NbExp=3; IntAct=EBI-14115717, EBI-22734860;
CC Q8N7U7-2; O43482: OIP5; NbExp=5; IntAct=EBI-14115717, EBI-536879;
CC Q8N7U7-2; P86480: PRR20D; NbExp=3; IntAct=EBI-14115717, EBI-12754095;
CC Q8N7U7-2; Q9UJW9: SERTAD3; NbExp=3; IntAct=EBI-14115717, EBI-748621;
CC Q8N7U7-2; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-14115717, EBI-739895;
CC Q8N7U7-2; Q8WWF5: ZNRF4; NbExp=3; IntAct=EBI-14115717, EBI-2129267;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N7U7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N7U7-2; Sequence=VSP_027444;
CC -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
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DR EMBL; AK097640; BAC05130.1; -; mRNA.
DR EMBL; AC008745; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC137501; AAI37502.1; -; mRNA.
DR EMBL; BC141863; AAI41864.1; -; mRNA.
DR RefSeq; NP_940881.2; NM_198479.2. [Q8N7U7-1]
DR AlphaFoldDB; Q8N7U7; -.
DR SMR; Q8N7U7; -.
DR BioGRID; 129840; 19.
DR IntAct; Q8N7U7; 14.
DR STRING; 9606.ENSP00000323455; -.
DR iPTMnet; Q8N7U7; -.
DR PhosphoSitePlus; Q8N7U7; -.
DR BioMuta; TPRX1; -.
DR DMDM; 269849733; -.
DR MassIVE; Q8N7U7; -.
DR PaxDb; Q8N7U7; -.
DR PeptideAtlas; Q8N7U7; -.
DR PRIDE; Q8N7U7; -.
DR Antibodypedia; 31633; 97 antibodies from 22 providers.
DR DNASU; 284355; -.
DR Ensembl; ENST00000322175.7; ENSP00000323455.3; ENSG00000178928.8. [Q8N7U7-1]
DR GeneID; 284355; -.
DR KEGG; hsa:284355; -.
DR UCSC; uc002php.3; human. [Q8N7U7-1]
DR CTD; 284355; -.
DR GeneCards; TPRX1; -.
DR HGNC; HGNC:32174; TPRX1.
DR HPA; ENSG00000178928; Tissue enhanced (retina, testis).
DR MIM; 611166; gene.
DR neXtProt; NX_Q8N7U7; -.
DR OpenTargets; ENSG00000178928; -.
DR PharmGKB; PA142670706; -.
DR VEuPathDB; HostDB:ENSG00000178928; -.
DR eggNOG; KOG2251; Eukaryota.
DR GeneTree; ENSGT00940000164595; -.
DR HOGENOM; CLU_055641_0_0_1; -.
DR InParanoid; Q8N7U7; -.
DR OMA; KDSGSQY; -.
DR OrthoDB; 1270742at2759; -.
DR PathwayCommons; Q8N7U7; -.
DR SignaLink; Q8N7U7; -.
DR BioGRID-ORCS; 284355; 6 hits in 1069 CRISPR screens.
DR GenomeRNAi; 284355; -.
DR Pharos; Q8N7U7; Tdark.
DR PRO; PR:Q8N7U7; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8N7U7; protein.
DR Bgee; ENSG00000178928; Expressed in left testis and 3 other tissues.
DR ExpressionAtlas; Q8N7U7; baseline and differential.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Repeat.
FT CHAIN 1..411
FT /note="Tetra-peptide repeat homeobox protein 1"
FT /id="PRO_0000285591"
FT DNA_BIND 3..24
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 20..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 88..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..246
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 315..335
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 206..209
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027444"
FT CONFLICT 206
FT /note="P -> L (in Ref. 1; BAC05130)"
FT /evidence="ECO:0000305"
FT CONFLICT 304
FT /note="P -> L (in Ref. 1; BAC05130)"
FT /evidence="ECO:0000305"
FT CONFLICT 329
FT /note="A -> V (in Ref. 3; AAI41864)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 411 AA; 40603 MW; 22507B5AC5EFD40C CRC64;
MLSLREQQLQ VWFKNRRAKL ARERRLQQQP QRVPGQRGRG ARAAPLVPAA SASAPQRGPS
GILPAAEPTI CSLHQAWGGP GCRAQKGIPA ALSPGPGPIP APIPGPAQIP GPLPGSIPGP
IPGPAQIPSP IPAPIPGPIS GPVQIPGPFR GPIPGPISGP APIPGPISGP FSGPNPGPIP
GPNPGPIPGP ISGPIPGPIS VPIPGPIPGP ISGPISGPNP GPIPGPIPGP ISGPNPGPIP
GPISGPNPGL IPGPIPGPIS GPGPIIGPIP SPAQIPGPGR LQGPGPILSP GRMRSPGSLP
GLAPILGPGS GPGSGSVPAP IPGPGSLPAP APLWPQSPDA SDFLPDTQLF PHFTELLLPL
DPLEGSSVST MTSQYQEGDD SMGKKHSGSQ PQEEGGSVNE NHSGPRLLLD L
