ID   TPRX2_HUMAN             Reviewed;         301 AA.
AC   P0DV77;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   25-MAY-2022, sequence version 1.
DT   03-AUG-2022, entry version 2.
DE   RecName: Full=Tetrapeptide repeat homeobox protein 2 {ECO:0000305};
GN   Name=TPRX2 {ECO:0000312|HGNC:HGNC:32175};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=27412763; DOI=10.1038/srep28995;
RA   Madissoon E., Jouhilahti E.M., Vesterlund L., Toehoenen V., Krjutskov K.,
RA   Petropoulos S., Einarsdottir E., Linnarsson S., Lanner F., Maansson R.,
RA   Hovatta O., Buerglin T.R., Katayama S., Kere J.;
RT   "Characterization and target genes of nine human PRD-like homeobox domain
RT   genes expressed exclusively in early embryos.";
RL   Sci. Rep. 6:28995-28995(2016).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
CC   -!- FUNCTION: Transcription factor that acts as repressor.
CC       {ECO:0000269|PubMed:27412763}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in single blastomeres from 8-cell stage
CC       embryos. {ECO:0000269|PubMed:27412763}.
CC   -!- SIMILARITY: Belongs to the paired homeobox family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC024582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; LN901405; -; NOT_ANNOTATED_CDS; mRNA.
DR   HGNC; HGNC:32175; TPRX2.
DR   Proteomes; UP000005640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..301
FT                   /note="Tetrapeptide repeat homeobox protein 2"
FT                   /id="PRO_0000455535"
FT   DNA_BIND        20..79
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          273..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        16
FT                   /note="P -> T (in Ref. 1; LN901405)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        31
FT                   /note="Q -> R (in Ref. 1; LN901405)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   301 AA;  32608 MW;  88ECA2E2E00C8614 CRC64;
     MQDPGHLQGP PLALDPPRRQ RQERTVYTES QQKVLEFYFQ KDQYPNYDQR LNLAEMLSLR
     EQQLQVWFKN RRAKLARERR LQQQPQRVPG QRGRGARAAP LVPVAAASFP GGPEFPQGRG
     SWISPQPGPW GVLPAAEPKI YSLPRTWGGP ECGTQEGLKA VPAPGPGPIP APIPGPAQIP
     GPVPGPAPNL GPMSGPLSVS IPGPIPAPIS CPGPIPDPVL GRTLMPGPGS LPTPAPGALW
     PQSPYASNLS PDTQLYPDFT KLLPLLDRFE ESSLSTTTSQ YKEEDGFVDK NHSVPRSLLD
     L