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TPS05_ARATH
ID   TPS05_ARATH             Reviewed;         596 AA.
AC   O22184; F4ILI0;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2011, sequence version 2.
DT   03-AUG-2022, entry version 120.
DE   RecName: Full=Putative terpenoid synthase 5;
DE            Short=AtTPS05;
DE            EC=4.2.3.-;
GN   Name=TPS05; OrderedLocusNames=At2g23230; ORFNames=T20D16.14;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA   Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA   Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA   Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA   Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=12207221; DOI=10.1007/s00438-002-0709-y;
RA   Aubourg S., Lecharny A., Bohlmann J.;
RT   "Genomic analysis of the terpenoid synthase (AtTPS) gene family of
RT   Arabidopsis thaliana.";
RL   Mol. Genet. Genomics 267:730-745(2002).
RN   [4]
RP   GENE FAMILY.
RX   PubMed=12777052; DOI=10.1023/a:1023005504702;
RA   Lange B.M., Ghassemian M.;
RT   "Genome organization in Arabidopsis thaliana: a survey for genes involved
RT   in isoprenoid and chlorophyll metabolism.";
RL   Plant Mol. Biol. 51:925-948(2003).
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC       Note=Binds 3 Mg(2+) or Mn(2+) ions per subunit. {ECO:0000250};
CC   -!- PATHWAY: Secondary metabolite biosynthesis; terpenoid biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- DOMAIN: The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for
CC       the catalytic activity, presumably through binding to Mg(2+).
CC   -!- SIMILARITY: Belongs to the terpene synthase family. Tpsa subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB87108.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=AEC07431.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC002391; AAB87108.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002685; AEC07431.1; ALT_SEQ; Genomic_DNA.
DR   PIR; T00509; T00509.
DR   RefSeq; NP_179904.3; NM_127887.4.
DR   AlphaFoldDB; O22184; -.
DR   SMR; O22184; -.
DR   STRING; 3702.AT2G23230.1; -.
DR   PaxDb; O22184; -.
DR   PRIDE; O22184; -.
DR   GeneID; 816855; -.
DR   KEGG; ath:AT2G23230; -.
DR   Araport; AT2G23230; -.
DR   TAIR; locus:2058608; AT2G23230.
DR   eggNOG; ENOG502QUCN; Eukaryota.
DR   HOGENOM; CLU_003125_7_2_1; -.
DR   InParanoid; O22184; -.
DR   PhylomeDB; O22184; -.
DR   UniPathway; UPA00213; -.
DR   PRO; PR:O22184; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; O22184; baseline and differential.
DR   Genevisible; O22184; AT.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009975; F:cyclase activity; IBA:GO_Central.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0010333; F:terpene synthase activity; IEA:InterPro.
DR   GO; GO:0016102; P:diterpenoid biosynthetic process; IEA:InterPro.
DR   GO; GO:0051762; P:sesquiterpene biosynthetic process; IBA:GO_Central.
DR   CDD; cd00684; Terpene_cyclase_plant_C1; 1.
DR   Gene3D; 1.10.600.10; -; 1.
DR   Gene3D; 1.50.10.130; -; 1.
DR   InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR   InterPro; IPR044814; Terpene_cyclase_plant_C1.
DR   InterPro; IPR001906; Terpene_synth_N.
DR   InterPro; IPR036965; Terpene_synth_N_sf.
DR   InterPro; IPR005630; Terpene_synthase_metal-bd.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   Pfam; PF01397; Terpene_synth; 1.
DR   Pfam; PF03936; Terpene_synth_C; 1.
DR   SUPFAM; SSF48239; SSF48239; 1.
DR   SUPFAM; SSF48576; SSF48576; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Lyase; Magnesium; Manganese; Metal-binding; Reference proteome.
FT   CHAIN           1..596
FT                   /note="Putative terpenoid synthase 5"
FT                   /id="PRO_0000403701"
FT   MOTIF           349..353
FT                   /note="DDXXD motif"
FT   BINDING         349
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         349
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         353
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         353
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         481
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000250"
FT   BINDING         489
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   596 AA;  68487 MW;  4B87DC47ADCEC589 CRC64;
     MKTLTFFGPK YGTQVSLLSP NVVSKLSRFP LTSFARKPTK PVCVKTTDCD LVESQRTFNK
     FPRSDWGDHF LRLPFNVSDM DMLTIEMNAL KSTIRKMLMY SQDVEETKER ILIIYLLVAL
     GMAYHFEDEI DDNLKHGFEN IETTMAGEND LSTVSVMFWV FRTYGYNLSS DMFRRFKGED
     GKFEECHTKD VKGLLSLYEA AQLGTSTEDI LDEAMSFSSS HLECLAGGTC PPHISRLIQN
     ELYMPQHHNA EILFASEYIS FYKQEDVHNK VLLEFAKLNF KFLQLHWIHE LKILTKWWND
     QDLLSKLPPY FRDRMVECHL YAVIYYFEPQ YSFGRIMLAK LLVLLTVVDD TCDRYGSVPE
     VAKLLDCVER WDPELGESLP DYLKTVFKFT LDVFEDCERA GKSEEGLSFN VDGALAEWAA
     AEKVPTVEEY LEVGGVAVTM YATIALGLLG LGPKAREHGY EWLKSRPKLV HDLATKGRLM
     NDMGGFKDDI GRGFLANVVN YYMKEYGTTE EETYKEFHKI VRDLEKSVNS EFLKINKGVP
     REILSRALNC GKMIDVTYRS GDGYTRPRGK FTEYVESLFV EHMDAPVMQY ASSSTL
 
 
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