TPS17_ARATH
ID TPS17_ARATH Reviewed; 601 AA.
AC Q9LRR2;
DT 11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Terpenoid synthase 17;
DE Short=AtTPS17;
DE EC=4.2.3.-;
GN Name=TPS17; OrderedLocusNames=At3g14490; ORFNames=MOA2.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12207221; DOI=10.1007/s00438-002-0709-y;
RA Aubourg S., Lecharny A., Bohlmann J.;
RT "Genomic analysis of the terpenoid synthase (AtTPS) gene family of
RT Arabidopsis thaliana.";
RL Mol. Genet. Genomics 267:730-745(2002).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=12566586; DOI=10.1105/tpc.007989;
RA Chen F., Tholl D., D'Auria J.C., Farooq A., Pichersky E., Gershenzon J.;
RT "Biosynthesis and emission of terpenoid volatiles from Arabidopsis
RT flowers.";
RL Plant Cell 15:481-494(2003).
RN [5]
RP GENE FAMILY.
RX PubMed=12777052; DOI=10.1023/a:1023005504702;
RA Lange B.M., Ghassemian M.;
RT "Genome organization in Arabidopsis thaliana: a survey for genes involved
RT in isoprenoid and chlorophyll metabolism.";
RL Plant Mol. Biol. 51:925-948(2003).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250};
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
CC Note=Binds 3 Mg(2+) or Mn(2+) ions per subunit. {ECO:0000250};
CC -!- PATHWAY: Secondary metabolite biosynthesis; terpenoid biosynthesis.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed exclusively in flowers.
CC {ECO:0000269|PubMed:12566586}.
CC -!- DOMAIN: The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for
CC the catalytic activity, presumably through binding to Mg(2+).
CC -!- SIMILARITY: Belongs to the terpene synthase family. Tpsa subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB01341.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB028617; BAB01341.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE75532.1; -; Genomic_DNA.
DR RefSeq; NP_188067.1; NM_112309.2.
DR AlphaFoldDB; Q9LRR2; -.
DR SMR; Q9LRR2; -.
DR STRING; 3702.AT3G14490.1; -.
DR PaxDb; Q9LRR2; -.
DR PRIDE; Q9LRR2; -.
DR EnsemblPlants; AT3G14490.1; AT3G14490.1; AT3G14490.
DR GeneID; 820672; -.
DR Gramene; AT3G14490.1; AT3G14490.1; AT3G14490.
DR KEGG; ath:AT3G14490; -.
DR Araport; AT3G14490; -.
DR TAIR; locus:2091687; AT3G14490.
DR eggNOG; ENOG502QUCN; Eukaryota.
DR HOGENOM; CLU_003125_7_2_1; -.
DR InParanoid; Q9LRR2; -.
DR OMA; RLRGYYM; -.
DR OrthoDB; 360509at2759; -.
DR PhylomeDB; Q9LRR2; -.
DR BioCyc; ARA:AT3G14490-MON; -.
DR UniPathway; UPA00213; -.
DR PRO; PR:Q9LRR2; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LRR2; baseline and differential.
DR Genevisible; Q9LRR2; AT.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009975; F:cyclase activity; IBA:GO_Central.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0010333; F:terpene synthase activity; IEA:InterPro.
DR GO; GO:0016102; P:diterpenoid biosynthetic process; IEA:InterPro.
DR GO; GO:0051762; P:sesquiterpene biosynthetic process; IBA:GO_Central.
DR CDD; cd00684; Terpene_cyclase_plant_C1; 1.
DR Gene3D; 1.10.600.10; -; 1.
DR Gene3D; 1.50.10.130; -; 1.
DR InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR InterPro; IPR034741; Terpene_cyclase-like_1_C.
DR InterPro; IPR044814; Terpene_cyclase_plant_C1.
DR InterPro; IPR001906; Terpene_synth_N.
DR InterPro; IPR036965; Terpene_synth_N_sf.
DR InterPro; IPR005630; Terpene_synthase_metal-bd.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR Pfam; PF01397; Terpene_synth; 1.
DR Pfam; PF03936; Terpene_synth_C; 1.
DR SFLD; SFLDG01019; Terpene_Cyclase_Like_1_C_Termi; 1.
DR SUPFAM; SSF48239; SSF48239; 1.
DR SUPFAM; SSF48576; SSF48576; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Lyase; Magnesium; Manganese; Metal-binding; Reference proteome.
FT CHAIN 1..601
FT /note="Terpenoid synthase 17"
FT /id="PRO_0000403708"
FT MOTIF 354..358
FT /note="DDXXD motif; degenerate"
FT BINDING 354
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 354
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 358
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="1"
FT /evidence="ECO:0000250"
FT BINDING 358
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="2"
FT /evidence="ECO:0000250"
FT BINDING 497
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
FT BINDING 501
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
FT BINDING 505
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /ligand_label="3"
FT /evidence="ECO:0000250"
SQ SEQUENCE 601 AA; 70179 MW; F8382AFBB22CE84B CRC64;
MEATRTSFGL HNAPLCPTTN PSLFPRRWLH KHTLSLKPAK QHHLVCVRAT ESNDNLESSR
PLAHFSPTLW GDHFLSVPLH VAEFDDFSRE IEVTMKPKVR DMLKSSKNSD NERIRLIHLL
MNLGIAYHFE IEIDEILGQA FGNLDDIIAK ENDLETISTM FEVFRLRGYY MPCYAFNRFK
GEDGRFKESL AEDIRGMLQL YEAAHLGTPS EDIMDEALSF TRYRLESLTS NHTATASPHL
SKHIQNALYR ARYHNLEILV AREYISFYEQ EEDHDETLLK FAKLNFNYCQ LHYIQELKDL
TKWWKELDLA SKLPYIRDRI VEVYFGALAL YFEPRYSLGR IIVTKITMIV TVFNDTCDAY
GTLPEVTSLV DSFQRWDLGD IEKLPSYVKI VFRGVFETLE EIEQEMRPQG RSRIVQVAVD
EIKKLGKAYL AISKWARASH VPTFEEYMEF GMQTSMDHFA AYSFIAMEDC DENQTCEWYK
SRPKMMEALN GVFRIKNDIN TFEQEMSRGE VAKGLNCYMK QHGVSKEEAI GEMNKIYSNY
YKIIMEEYLT TTAVPRPILV RCLNVSRPIH HFYKERDEFT DPYFGMLKEV ITSLFIHPIP
L
