ID   BTUFA_HALS3             Reviewed;         369 AA.
AC   B0R5G2;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Cobalamin-binding protein;
DE   AltName: Full=Vitamin B12-binding protein;
DE   Flags: Precursor;
GN   Name=btuF; OrderedLocusNames=OE_2951R;
OS   Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=478009;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29341 / DSM 671 / R1;
RX   PubMed=18313895; DOI=10.1016/j.ygeno.2008.01.001;
RA   Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K.,
RA   Ruepp A., Soppa J., Tittor J., Oesterhelt D.;
RT   "Evolution in the laboratory: the genome of Halobacterium salinarum strain
RT   R1 compared to that of strain NRC-1.";
RL   Genomics 91:335-346(2008).
CC   -!- FUNCTION: Required for corrinoid utilization. Probably part of the ABC
CC       transporter complex BtuCDF involved in cobalamin (vitamin B12) import.
CC       Probably binds cobalamin and delivers it to the surface of BtuC (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (BtuD),
CC       two transmembrane proteins (BtuC) and a solute-binding protein (BtuF).
CC       {ECO:0000250}.
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DR   EMBL; AM774415; CAP13979.1; -; Genomic_DNA.
DR   RefSeq; WP_010902993.1; NC_010364.1.
DR   AlphaFoldDB; B0R5G2; -.
DR   SMR; B0R5G2; -.
DR   EnsemblBacteria; CAP13979; CAP13979; OE_2951R.
DR   GeneID; 5954317; -.
DR   KEGG; hsl:OE_2951R; -.
DR   HOGENOM; CLU_038034_2_1_2; -.
DR   OMA; WQGINLE; -.
DR   PhylomeDB; B0R5G2; -.
DR   Proteomes; UP000001321; Chromosome.
DR   InterPro; IPR002491; ABC_transptr_periplasmic_BD.
DR   InterPro; IPR026469; Peripla_PGF_1.
DR   Pfam; PF01497; Peripla_BP_2; 1.
DR   TIGRFAMs; TIGR04281; peripla_PGF_1; 1.
DR   PROSITE; PS50983; FE_B12_PBP; 1.
PE   3: Inferred from homology;
KW   Signal; Transport.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..369
FT                   /note="Cobalamin-binding protein"
FT                   /id="PRO_0000408972"
FT   DOMAIN          62..319
FT                   /note="Fe/B12 periplasmic-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00344"
FT   REGION          322..343
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        322..342
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   369 AA;  37713 MW;  A0B96723BEB377C6 CRC64;
     MHRGRFATLV IVALAVTMTA PAGALAPQPP AQHADADRAC SFPVTEPDAS NTAITLDSEP
     ERVVTLNPSA AQTMWELGDR DAVVGVSQFG TYLPTASQRT VVSGGQPSQT NVEAVVGLDP
     DLVLAPNTVR NTTVTRLRSA GITVFQFRAA TSIDGVVEKT ATIGRLTGNC AAAAATTAEM
     RDRVAAIADA VPDTDSARPR VYYHLGDGYT AGPNTFIGAA IEAAGGHNIA ADVNTTSSYP
     QLSEEVIVSQ DPDVVVTGVS ADRLDATASA LVAPSSVVRN TTAYATGNVV AVNTNHINQP
     APRIVEPMAR MANAFHNTTI NTTLDAQPSA TTTATSTAPP TDAADGTAPG FGVAAAVCAL
     AGAALVARR