TPS2_ARATH
ID TPS2_ARATH Reviewed; 822 AA.
AC Q9FZ57; F4I627;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Probable alpha,alpha-trehalose-phosphate synthase [UDP-forming] 2;
DE EC=2.4.1.15;
DE AltName: Full=Trehalose-6-phosphate synthase 2;
DE Short=AtTPS2;
GN Name=TPS2; OrderedLocusNames=At1g16980; ORFNames=F6I1.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11701378; DOI=10.1016/s1360-1385(01)02125-2;
RA Leyman B., Van Dijck P., Thevelein J.M.;
RT "An unexpected plethora of trehalose biosynthesis genes in Arabidopsis
RT thaliana.";
RL Trends Plant Sci. 6:510-513(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-
CC trehalose 6-phosphate + H(+) + UDP; Xref=Rhea:RHEA:18889,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:58429,
CC ChEBI:CHEBI:58885, ChEBI:CHEBI:61548; EC=2.4.1.15;
CC -!- SIMILARITY: In the N-terminal section; belongs to the
CC glycosyltransferase 20 family. {ECO:0000305}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the trehalose
CC phosphatase family. {ECO:0000305}.
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DR EMBL; AC051629; AAF99834.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29528.2; -; Genomic_DNA.
DR PIR; E86305; E86305.
DR RefSeq; NP_173142.2; NM_101559.2.
DR AlphaFoldDB; Q9FZ57; -.
DR SMR; Q9FZ57; -.
DR STRING; 3702.AT1G16980.1; -.
DR CAZy; GT20; Glycosyltransferase Family 20.
DR PaxDb; Q9FZ57; -.
DR PRIDE; Q9FZ57; -.
DR ProteomicsDB; 228332; -.
DR EnsemblPlants; AT1G16980.1; AT1G16980.1; AT1G16980.
DR GeneID; 838269; -.
DR Gramene; AT1G16980.1; AT1G16980.1; AT1G16980.
DR KEGG; ath:AT1G16980; -.
DR Araport; AT1G16980; -.
DR eggNOG; KOG1050; Eukaryota.
DR HOGENOM; CLU_002351_0_1_1; -.
DR InParanoid; Q9FZ57; -.
DR OrthoDB; 772297at2759; -.
DR PhylomeDB; Q9FZ57; -.
DR PRO; PR:Q9FZ57; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9FZ57; baseline and differential.
DR Genevisible; Q9FZ57; AT.
DR GO; GO:0003825; F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity; IBA:GO_Central.
DR GO; GO:0004805; F:trehalose-phosphatase activity; IEA:UniProt.
DR GO; GO:0005992; P:trehalose biosynthetic process; IBA:GO_Central.
DR GO; GO:0070413; P:trehalose metabolism in response to stress; IBA:GO_Central.
DR CDD; cd03788; GT20_TPS; 1.
DR Gene3D; 3.40.50.1000; -; 1.
DR InterPro; IPR001830; Glyco_trans_20.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR012766; Trehalose_OtsA.
DR InterPro; IPR003337; Trehalose_PPase.
DR PANTHER; PTHR10788; PTHR10788; 1.
DR Pfam; PF00982; Glyco_transf_20; 1.
DR Pfam; PF02358; Trehalose_PPase; 1.
DR SUPFAM; SSF56784; SSF56784; 1.
DR TIGRFAMs; TIGR02400; trehalose_OtsA; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase; Reference proteome; Transferase.
FT CHAIN 1..822
FT /note="Probable alpha,alpha-trehalose-phosphate synthase
FT [UDP-forming] 2"
FT /id="PRO_0000324823"
FT REGION 12..479
FT /note="Glycosyltransferase"
SQ SEQUENCE 822 AA; 93005 MW; 6270EB4998DBD7D5 CRC64;
MMDYDDARGE RPRLLVVANR LPVSAKRTGE NSWSLEMSPG GLVSGLLGIT SQFDTKWVGW
PGVDVHDEIE KNALTESLAE MKCIPVFLNG VFDQYYNGYC NGILWPILHH MGLPQEDQHD
TNQTFETQYD AYKKANRMFL DVIIDNYEEG DIVWCHDYHL MFLPQYLKEY NNKIKVGWFL
HSPFPSSEVY KTLPSRSELL RAILAADLLG FHTYDFARHF LSTCTRILGV EGTHEGVVYQ
GRVTRVAVFP IGIDPDRFIR TCKLPEVTQQ MNELQEKFAG KKVILGVDRL DMIKGIPQKY
LAFEKFLEEN PYWRDKVVLV QIAVPTRNDV PEYRKLKSQV HGLVGRINGR FGSVSSLPIH
HLDCSVDFNY LCAIYAIADV MLVTSLRDGM NLVSYEFVAC QEAKKGVLVL SEFAGAGQSL
GVGALIVNPW DVTEVSSAIK EALNMPAEER ETRHRSNFQY VCTHSAEKWG LDFMSELNGI
IPESEMQMRK IPLQLPEQDV IQQYSQSNNR LIILGFFGTL AEPMNSGTKE MDLKLNPELK
GTLKALCNDP KTTVVVLSRS GKNILNKNFG ESNIWLAAEN GMFEKQTTGE WVTNMPQNVN
LDWVDGVKNV FKYFTDRTPR SYFEASETSL VWNYEYADVE FGRAQARDLL QYLWAGPISN
ASVDVVRGNH SVEVHAIGET KGAAIGRILG EIVHRKSMTT PIDFVFCSGY FLEKDEDIYT
FFESKILSSK SPNGLDLKKE NYFSAAIGQA RTKARYVIDS AHGVVDLLHK LAVVADTTMT
DSFSDSEIYE PRDANANENS KRWINSVRRR KVEIGDTGQI GM
