TPS3_ARATH
ID TPS3_ARATH Reviewed; 783 AA.
AC Q9SHG0; F4I628;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-JAN-2012, sequence version 3.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Probable alpha,alpha-trehalose-phosphate synthase [UDP-forming] 3;
DE EC=2.4.1.15;
DE AltName: Full=Trehalose-6-phosphate synthase 3;
DE Short=AtTPS3;
GN Name=TPS3; OrderedLocusNames=At1g17000; ORFNames=F20D23.30;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11701378; DOI=10.1016/s1360-1385(01)02125-2;
RA Leyman B., Van Dijck P., Thevelein J.M.;
RT "An unexpected plethora of trehalose biosynthesis genes in Arabidopsis
RT thaliana.";
RL Trends Plant Sci. 6:510-513(2001).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glucose 6-phosphate + UDP-alpha-D-glucose = alpha,alpha-
CC trehalose 6-phosphate + H(+) + UDP; Xref=Rhea:RHEA:18889,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:58429,
CC ChEBI:CHEBI:58885, ChEBI:CHEBI:61548; EC=2.4.1.15;
CC -!- SIMILARITY: In the N-terminal section; belongs to the
CC glycosyltransferase 20 family. {ECO:0000305}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the trehalose
CC phosphatase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD50035.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC007651; AAD50035.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE29529.1; -; Genomic_DNA.
DR PIR; F86305; F86305.
DR RefSeq; NP_173143.4; NM_101560.5.
DR AlphaFoldDB; Q9SHG0; -.
DR SMR; Q9SHG0; -.
DR STRING; 3702.AT1G17000.1; -.
DR CAZy; GT20; Glycosyltransferase Family 20.
DR PaxDb; Q9SHG0; -.
DR PeptideAtlas; Q9SHG0; -.
DR PRIDE; Q9SHG0; -.
DR ProteomicsDB; 228383; -.
DR GeneID; 838270; -.
DR KEGG; ath:AT1G17000; -.
DR Araport; AT1G17000; -.
DR eggNOG; KOG1050; Eukaryota.
DR HOGENOM; CLU_358125_0_0_1; -.
DR InParanoid; Q9SHG0; -.
DR OrthoDB; 772297at2759; -.
DR PRO; PR:Q9SHG0; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SHG0; baseline and differential.
DR Genevisible; Q9SHG0; AT.
DR GO; GO:0003825; F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity; IBA:GO_Central.
DR GO; GO:0005992; P:trehalose biosynthetic process; IBA:GO_Central.
DR GO; GO:0070413; P:trehalose metabolism in response to stress; IBA:GO_Central.
DR CDD; cd03788; GT20_TPS; 1.
DR InterPro; IPR001830; Glyco_trans_20.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR003337; Trehalose_PPase.
DR PANTHER; PTHR10788; PTHR10788; 1.
DR Pfam; PF00982; Glyco_transf_20; 1.
DR Pfam; PF02358; Trehalose_PPase; 1.
DR SUPFAM; SSF56784; SSF56784; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase; Reference proteome; Transferase.
FT CHAIN 1..783
FT /note="Probable alpha,alpha-trehalose-phosphate synthase
FT [UDP-forming] 3"
FT /id="PRO_0000324824"
FT REGION 11..456
FT /note="Glycosyltransferase"
SQ SEQUENCE 783 AA; 89483 MW; 262F05A09098887E CRC64;
MGYDNVCGER QTLLVVANRL PASAKRTGEH SWSLEMSPGG KFNLLVEKDA VSKSLAEMKC
IPVFLNEVFD QYYNGYSNGI LWPILHHMGL PQEYDHDTIK TFETQYDAYK KANRMFLDVI
KENYKDGDIV WCQDYHLMFL PQYLKEYNNK IKVGWFLHSP FPSSEIYKTL PSRSELLRSV
LAADLISFHT YDFARHFVNT CTRILGVEGT HEGVVYQGRV TRVVVLPMGI YPNRFIKTCK
LPEVIQQMNE LKDRFSGKKV ILGVDRLDMI KGIPQKYLGF EKFLDENPNW RDKIVLVQIA
VPTRNEVPEY QKLKNQVHRL VGRINGRFGS VSSLPIHHMD CSVDSNYLCA LYAISDVMLV
TSLRDGLNLV SHEFVACQEA KRGVLILSEF AGAGQSLGAG ALLVNPWNVT EVSSAIKKAL
NMPYEERETR HRVNFKYVKT HSAEKWGFDF LSELNDAFDE SELQIRKIPH ELPQQDVIQR
YSLSNNRLII LGFYGTITEP RNSLSKEMDL KLNPELKETL KALCNDPKTT VVVLSRSGKN
ILDKNFGEYK IWLAAENGMF LKHTTEEWVT NMPQNMNLDW VDGLKNVFKY FTDRTPRSFF
EASKTSLVWN YEYADVEFGR AQARDLLQYL WAGPISNASA EVVRGKYSVE VHAIGVTKEP
EIGHILGEIV HKKAMTTPID YVFCSGYFLE KDEDIYTFFE SEILSPKLSH ETRSKSSSSN
HSLEKKVSLN VLDLKQENYF STAIGQARTK ARYVVDSSHN VVNLLHKLAV ANTTTTSVKK
PNV
