TPTE_HUMAN
ID TPTE_HUMAN Reviewed; 551 AA.
AC P56180; B2RAP7; C9J6D6; C9JKK8; Q6XPS4; Q6XPS5; Q71JA8; Q8NCS8;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 3.
DT 03-AUG-2022, entry version 180.
DE RecName: Full=Putative tyrosine-protein phosphatase TPTE;
DE EC=3.1.3.48;
DE AltName: Full=Cancer/testis antigen 44;
DE Short=CT44;
DE AltName: Full=Transmembrane phosphatase with tensin homology;
DE AltName: Full=Tumor antigen BJ-HCC-5;
GN Name=TPTE;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND VARIANTS
RP GLU-386 AND PRO-470.
RC TISSUE=Testis;
RX PubMed=10598804; DOI=10.1007/s004390051122;
RA Chen H., Rossier C., Morris M.A., Scott H.S., Gos A., Bairoch A.,
RA Antonarakis S.E.;
RT "A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine
RT phosphatase and maps to the pericentromeric region of human chromosomes 21
RT and 13, and to chromosomes 15, 22, and Y.";
RL Hum. Genet. 105:399-409(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4), AND VARIANTS GLU-386 AND
RP PRO-470.
RX PubMed=14659893; DOI=10.1016/j.gene.2003.09.038;
RA Tapparel C., Reymond A., Girardet C., Guillou L., Lyle R., Lamon C.,
RA Hutter P., Antonarakis S.E.;
RT "The TPTE gene family: cellular expression, subcellular localization and
RT alternative splicing.";
RL Gene 323:189-199(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND VARIANT GLU-386.
RC TISSUE=Hepatoma;
RA Dong X.-Y., Chen W.-F.;
RT "Cloning and identification of genes which are differentially expressed in
RT hepatocellular carcinoma.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLU-386.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANTS GLU-386
RP AND PRO-470.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP VARIANT [LARGE SCALE ANALYSIS] GLN-144.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: Could be involved in signal transduction.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC -!- INTERACTION:
CC P56180; Q9Y490: TLN1; NbExp=3; IntAct=EBI-3914809, EBI-2462036;
CC P56180-2; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-11960323, EBI-16439278;
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1; Synonyms=Alpha;
CC IsoId=P56180-1; Sequence=Displayed;
CC Name=2; Synonyms=Beta;
CC IsoId=P56180-2; Sequence=VSP_017321;
CC Name=3; Synonyms=Gamma;
CC IsoId=P56180-3; Sequence=VSP_017320;
CC Name=4; Synonyms=Delta;
CC IsoId=P56180-4; Sequence=VSP_017319;
CC -!- TISSUE SPECIFICITY: Exclusively expressed in testis.
CC {ECO:0000269|PubMed:10598804}.
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DR EMBL; AF007118; AAC34574.1; -; mRNA.
DR EMBL; AY219886; AAP45143.1; -; mRNA.
DR EMBL; AY219887; AAP45144.1; -; mRNA.
DR EMBL; AY219888; AAP45145.1; -; mRNA.
DR EMBL; AF495908; AAQ06674.1; -; mRNA.
DR EMBL; AK314285; BAG36944.1; -; mRNA.
DR EMBL; AF254982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF254983; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL078471; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL163201; CAB90528.1; -; Genomic_DNA.
DR EMBL; BC028719; AAH28719.1; -; mRNA.
DR CCDS; CCDS74771.1; -. [P56180-1]
DR CCDS; CCDS74772.1; -. [P56180-2]
DR CCDS; CCDS74773.1; -. [P56180-3]
DR CCDS; CCDS77617.1; -. [P56180-4]
DR RefSeq; NP_001277153.1; NM_001290224.1. [P56180-4]
DR RefSeq; NP_954868.1; NM_199259.3. [P56180-2]
DR RefSeq; NP_954869.1; NM_199260.3. [P56180-3]
DR RefSeq; NP_954870.2; NM_199261.3. [P56180-1]
DR AlphaFoldDB; P56180; -.
DR SMR; P56180; -.
DR BioGRID; 113031; 128.
DR IntAct; P56180; 84.
DR MINT; P56180; -.
DR STRING; 9606.ENSP00000484403; -.
DR DEPOD; TPTE; -.
DR iPTMnet; P56180; -.
DR PhosphoSitePlus; P56180; -.
DR BioMuta; TPTE; -.
DR DMDM; 313104272; -.
DR jPOST; P56180; -.
DR MassIVE; P56180; -.
DR PaxDb; P56180; -.
DR PeptideAtlas; P56180; -.
DR PRIDE; P56180; -.
DR ProteomicsDB; 56895; -. [P56180-1]
DR ProteomicsDB; 56896; -. [P56180-2]
DR ProteomicsDB; 56897; -. [P56180-3]
DR ProteomicsDB; 56898; -. [P56180-4]
DR Antibodypedia; 73437; 308 antibodies from 34 providers.
DR DNASU; 7179; -.
DR Ensembl; ENST00000427445.6; ENSP00000482488.1; ENSG00000274391.5. [P56180-3]
DR Ensembl; ENST00000612746.1; ENSP00000483087.1; ENSG00000274391.5. [P56180-4]
DR Ensembl; ENST00000618007.5; ENSP00000484403.1; ENSG00000274391.5. [P56180-1]
DR Ensembl; ENST00000622113.4; ENSP00000482040.1; ENSG00000274391.5. [P56180-2]
DR GeneID; 7179; -.
DR KEGG; hsa:7179; -.
DR MANE-Select; ENST00000618007.5; ENSP00000484403.1; NM_199261.4; NP_954870.3.
DR UCSC; uc002yip.2; human. [P56180-1]
DR CTD; 7179; -.
DR DisGeNET; 7179; -.
DR GeneCards; TPTE; -.
DR HGNC; HGNC:12023; TPTE.
DR HPA; ENSG00000274391; Tissue enriched (testis).
DR MIM; 604336; gene.
DR neXtProt; NX_P56180; -.
DR OpenTargets; ENSG00000274391; -.
DR PharmGKB; PA36702; -.
DR VEuPathDB; HostDB:ENSG00000274391; -.
DR eggNOG; KOG2283; Eukaryota.
DR GeneTree; ENSGT00940000154335; -.
DR HOGENOM; CLU_020105_3_0_1; -.
DR InParanoid; P56180; -.
DR OMA; THGGVEN; -.
DR OrthoDB; 639380at2759; -.
DR PhylomeDB; P56180; -.
DR TreeFam; TF354329; -.
DR PathwayCommons; P56180; -.
DR Reactome; R-HSA-1660514; Synthesis of PIPs at the Golgi membrane.
DR SignaLink; P56180; -.
DR BioGRID-ORCS; 7179; 28 hits in 1033 CRISPR screens.
DR ChiTaRS; TPTE; human.
DR GeneWiki; TPTE; -.
DR GenomeRNAi; 7179; -.
DR Pharos; P56180; Tbio.
DR PRO; PR:P56180; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; P56180; protein.
DR Bgee; ENSG00000274391; Expressed in right testis and 25 other tissues.
DR ExpressionAtlas; P56180; baseline and differential.
DR Genevisible; P56180; HS.
DR GO; GO:0042995; C:cell projection; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; TAS:ProtInc.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0016314; F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity; IBA:GO_Central.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IBA:GO_Central.
DR GO; GO:0048870; P:cell motility; IBA:GO_Central.
DR GO; GO:0016311; P:dephosphorylation; IBA:GO_Central.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0014065; P:phosphatidylinositol 3-kinase signaling; IBA:GO_Central.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IBA:GO_Central.
DR GO; GO:0006470; P:protein dephosphorylation; IBA:GO_Central.
DR GO; GO:0051896; P:regulation of protein kinase B signaling; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR CDD; cd14510; PTP_VSP_TPTE; 1.
DR Gene3D; 1.20.120.350; -; 1.
DR Gene3D; 3.90.190.10; -; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR045102; PTP_VSP_TPTE.
DR InterPro; IPR014020; Tensin_C2-dom.
DR InterPro; IPR029023; Tensin_phosphatase.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR Pfam; PF10409; PTEN_C2; 1.
DR SMART; SM01326; PTEN_C2; 1.
DR SUPFAM; SSF49562; SSF49562; 1.
DR SUPFAM; SSF52799; SSF52799; 1.
DR PROSITE; PS51182; C2_TENSIN; 1.
DR PROSITE; PS51181; PPASE_TENSIN; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Hydrolase; Membrane; Protein phosphatase;
KW Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..551
FT /note="Putative tyrosine-protein phosphatase TPTE"
FT /id="PRO_0000215907"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 228..404
FT /note="Phosphatase tensin-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00590"
FT DOMAIN 411..540
FT /note="C2 tensin-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00589"
FT REGION 1..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 338
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..138
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14659893"
FT /id="VSP_017319"
FT VAR_SEQ 41..78
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14659893"
FT /id="VSP_017320"
FT VAR_SEQ 41..58
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14659893,
FT ECO:0000303|PubMed:15489334, ECO:0000303|Ref.3"
FT /id="VSP_017321"
FT VARIANT 144
FT /note="R -> Q (in a breast cancer sample; somatic mutation;
FT dbSNP:rs144333919)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_036516"
FT VARIANT 195
FT /note="R -> Q (in dbSNP:rs1810856)"
FT /id="VAR_057347"
FT VARIANT 386
FT /note="K -> E (in dbSNP:rs212146)"
FT /evidence="ECO:0000269|PubMed:10598804,
FT ECO:0000269|PubMed:14659893, ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.3"
FT /id="VAR_065097"
FT VARIANT 470
FT /note="L -> P (in dbSNP:rs150482)"
FT /evidence="ECO:0000269|PubMed:10598804,
FT ECO:0000269|PubMed:14659893, ECO:0000269|PubMed:15489334"
FT /id="VAR_025400"
FT VARIANT 482
FT /note="Y -> S (in dbSNP:rs9996)"
FT /id="VAR_061895"
FT VARIANT 549
FT /note="G -> E (in dbSNP:rs169758)"
FT /id="VAR_057348"
SQ SEQUENCE 551 AA; 64322 MW; 48C2F28BEAA0DDA6 CRC64;
MNESPDPTDL AGVIIELGPN DSPQTSEFKG ATEEAPAKES PHTSEFKGAA RVSPISESVL
ARLSKFEVED AENVASYDSK IKKIVHSIVS SFAFGLFGVF LVLLDVTLIL ADLIFTDSKL
YIPLEYRSIS LAIALFFLMD VLLRVFVERR QQYFSDLFNI LDTAIIVILL LVDVVYIFFD
IKLLRNIPRW THLLRLLRLI ILLRIFHLFH QKRQLEKLIR RRVSENKRRY TRDGFDLDLT
YVTERIIAMS FPSSGRQSFY RNPIKEVVRF LDKKHRNHYR VYNLCSERAY DPKHFHNRVV
RIMIDDHNVP TLHQMVVFTK EVNEWMAQDL ENIVAIHCKG GTDRTGTMVC AFLIASEICS
TAKESLYYFG ERRTDKTHSE KFQGVKTPSQ KRYVAYFAQV KHLYNWNLPP RRILFIKHFI
IYSIPRYVRD LKIQIEMEKK VVFSTISLGK CSVLDNITTD KILIDVFDGL PLYDDVKVQF
FYSNLPTYYD NCSFYFWLHT SFIENNRLYL PKNELDNLHK QKARRIYPSD FAVEILFGEK
MTSSDVVAGS D
