ID   TPX_CLOPA               Reviewed;          20 AA.
AC   P81361;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Thiol peroxidase;
DE            Short=Tpx;
DE            EC=1.11.1.24 {ECO:0000250|UniProtKB:P0A862};
DE   AltName: Full=CP 42;
DE   AltName: Full=Peroxiredoxin tpx;
DE            Short=Prx;
DE   AltName: Full=Thioredoxin peroxidase;
DE   AltName: Full=Thioredoxin-dependent peroxiredoxin;
DE   Flags: Fragment;
GN   Name=tpx;
OS   Clostridium pasteurianum.
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=1501;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   STRAIN=ATCC 6013 / DSM 525 / NCIB 9486 / VKM B-1774 / W5;
RX   PubMed=9629918; DOI=10.1002/elps.1150190533;
RA   Flengsrud R., Skjeldal L.;
RT   "Two-dimensional gel electrophoresis separation and N-terminal sequence
RT   analysis of proteins from Clostridium pasteurianum W5.";
RL   Electrophoresis 19:802-806(1998).
CC   -!- FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of
CC       hydrogen peroxide and organic hydroperoxides to water and alcohols,
CC       respectively. Plays a role in cell protection against oxidative stress
CC       by detoxifying peroxides. {ECO:0000250|UniProtKB:P0A862}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-
CC         disulfide + an alcohol + H2O; Xref=Rhea:RHEA:62620, Rhea:RHEA-
CC         COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:29950, ChEBI:CHEBI:30879, ChEBI:CHEBI:35924,
CC         ChEBI:CHEBI:50058; EC=1.11.1.24;
CC         Evidence={ECO:0000250|UniProtKB:P0A862};
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P0A862}.
CC   -!- MISCELLANEOUS: On the 2D-gel the determined pI of this protein is: 4.6,
CC       its MW is: 20.2 kDa.
CC   -!- SIMILARITY: Belongs to the peroxiredoxin family. Tpx subfamily.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; P81361; -.
DR   GO; GO:0004601; F:peroxidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0051920; F:peroxiredoxin activity; IEA:UniProtKB-EC.
PE   1: Evidence at protein level;
KW   Antioxidant; Direct protein sequencing; Oxidoreductase; Peroxidase.
FT   CHAIN           1..>20
FT                   /note="Thiol peroxidase"
FT                   /id="PRO_0000187874"
FT   NON_TER         20
SQ   SEQUENCE   20 AA;  2193 MW;  08178FCD2782E765 CRC64;
     MKVTFQGNEV TLQGKEVKVG