ID   TP_NEOBT                Reviewed;         564 AA.
AC   Q6F5E3;
DT   30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Aspyridones efflux protein {ECO:0000303|PubMed:14745177};
GN   Name=TP;
OS   Neocamarosporium betae (Beet black rot fungus) (Pleospora betae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae;
OC   Neocamarosporium.
OX   NCBI_TaxID=1979465;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND IDENTIFICATION OF GENE CLUSTER.
RC   STRAIN=PS-16;
RX   PubMed=14745177; DOI=10.1271/bbb.68.146;
RA   Toyomasu T., Nakaminami K., Toshima H., Mie T., Watanabe K., Ito H.,
RA   Matsui H., Mitsuhashi W., Sassa T., Oikawa H.;
RT   "Cloning of a gene cluster responsible for the biosynthesis of diterpene
RT   aphidicolin, a specific inhibitor of DNA polymerase alpha.";
RL   Biosci. Biotechnol. Biochem. 68:146-152(2004).
CC   -!- FUNCTION: Efflux pump that may be involved in the secretion of leporins
CC       (PubMed:14745177). {ECO:0000305|PubMed:14745177}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. TCR/Tet
CC       family. {ECO:0000305}.
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DR   EMBL; AB114137; BAD29973.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q6F5E3; -.
DR   SMR; Q6F5E3; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Glycoprotein; Membrane; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..564
FT                   /note="Aspyridones efflux protein"
FT                   /id="PRO_0000438564"
FT   TRANSMEM        66..86
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        216..236
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        260..280
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        335..355
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        368..388
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        392..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        416..436
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        454..474
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        528..548
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..42
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        415
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        524
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   564 AA;  60191 MW;  203CE6B6DD79F3F5 CRC64;
     MHPDQADTAA MQQQTTTECS DRSRPEKAEE GHAREHTVTR TCSREPEQTA TATKPTGLKL
     ICLTTAICLT IFLISVDFSI LATAIPAITA EFKSVADIGW YGSSYLLTTA SSQLLLGKCY
     TVFDLKWTFL LALLTFEVGS IICATAPSSV VLIIGRAIAG CGNAGLLSGA LLILTHSVPL
     EKRPLFMAMT GGTYGVAAIA GPPLGGVFTD KLSWRWCFWI NLPIGALTFL VIVFLFKSPP
     RSGFDGSRSW LAKVMRFDPV GTLMFMPAII CVLLALQWGG TTHAWNSGIV VALLVVGGVL
     VIAFGIVQWL MHDDATIPLR IIKKRTIWAC AAYQFALGAA FFVFIYFLPI WFQGVQGASA
     IQSGVRTLPM LVGNIVATAV SGVLVTIIGY YAPFMILGTI LASVGAGLLL LFTPNVTAAS
     WIGYQAIVGL GIGFGWQQPF VAVQTVLDIK DVPIATATLS FAQTLGGTLF VSVAQTAFST
     KLTQELVSQV PQLDPASILH EGGAAELDKL VPEQYLPDVV LSYNNSLLSA FFVATIMAIM
     SLVGCTFVEW NSVKGKKADA VPAA