TR102_MOUSE
ID TR102_MOUSE Reviewed; 329 AA.
AC Q7M717; Q71QD0;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 25-MAY-2022, entry version 85.
DE RecName: Full=Taste receptor type 2 member 102;
DE Short=T2R102;
DE Short=mT2R51;
DE AltName: Full=STC9-7;
GN Name=Tas2r102 {ECO:0000312|MGI:MGI:2681171};
GN Synonyms=T2r51 {ECO:0000303|PubMed:12679530};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAL85203.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11854532; DOI=10.1073/pnas.042617699;
RA Wu S.V., Rozengurt N., Yang M., Young S.H., Sinnett-Smith J., Rozengurt E.;
RT "Expression of bitter taste receptors of the T2R family in the
RT gastrointestinal tract and enteroendocrine STC-1 cells.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:2392-2397(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000305, ECO:0000312|EMBL:DAA01219.1}
RP IDENTIFICATION.
RX PubMed=12679530; DOI=10.1093/molbev/msg083;
RA Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT "Adaptive diversification of bitter taste receptor genes in mammalian
RT evolution.";
RL Mol. Biol. Evol. 20:805-814(2003).
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL85203.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF412306; AAL85203.1; ALT_INIT; Genomic_DNA.
DR EMBL; AC152822; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BK001080; DAA01219.1; -; Genomic_DNA.
DR AlphaFoldDB; Q7M717; -.
DR SMR; Q7M717; -.
DR STRING; 10090.ENSMUSP00000068332; -.
DR GlyGen; Q7M717; 1 site.
DR PaxDb; Q7M717; -.
DR PRIDE; Q7M717; -.
DR MGI; MGI:2681171; Tas2r102.
DR eggNOG; ENOG502TE6X; Eukaryota.
DR InParanoid; Q7M717; -.
DR PhylomeDB; Q7M717; -.
DR PRO; PR:Q7M717; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q7M717; protein.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
DR GO; GO:0032467; P:positive regulation of cytokinesis; ISO:MGI.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..329
FT /note="Taste receptor type 2 member 102"
FT /id="PRO_0000248246"
FT TOPO_DOM 1..9
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..30
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31..47
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 69..85
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..108
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..129
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 130..150
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 151..181
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..231
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..252
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 253..262
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 263..283
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 284..329
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 161
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 60
FT /note="L -> N (in Ref. 1; AAL85203)"
FT /evidence="ECO:0000305"
FT CONFLICT 155
FT /note="F -> V (in Ref. 1; AAL85203)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 329 AA; 38450 MW; 6E14E739082C9672 CRC64;
MNMESVLHNF ATVLIYVEFI FGNLSNGFIV LSNFLDWVIK QKLSLIDKIL LTLAISRITL
IWEIYAWFKS LYDPSSFLIG IEFQIIYFSW VLSSHFSLWL ATTLSVFYLL RIANCSWQIF
LYLKWRLKQL IVGMLLGSLV FLLGNLMQSM LEERFYQYGR NTSVNTMSND LAMWTELIFF
NMAMFSVIPF TLALISFLLL IFSLWKHLQK MQLISRRHRD PSTKAHMNAL RIMVSFLLLY
TMHFLSLLIS WIAQKHQSEL ADIIGMITEL MYPSVHSCIL ILGNSKLKQT SLCMLRHLRC
RLKGENITIA YSNQITSFCV FCVANKSMR
