ID   TR103_RAT               Reviewed;         312 AA.
AC   Q67ET5;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=Taste receptor type 2 member 103;
DE            Short=T2R103;
DE   AltName: Full=Taste receptor type 2 member 15;
DE            Short=T2R15;
GN   Name=Tas2r103 {ECO:0000250|UniProtKB:Q9JKA3}; Synonyms=Tas2r15;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:AAR13344.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAR13344.1};
RA   Conte C., Ebeling M., Marcuz A., Andres-Barquin P.J.;
RT   "Identification of new putative rat taste receptors belonging to the T2R
RT   family.";
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Gustducin-coupled receptor implicated in the perception of
CC       bitter compounds in the oral cavity and the gastrointestinal tract.
CC       Signals through PLCB2 and the calcium-regulated cation channel TRPM5
CC       (By similarity). {ECO:0000250|UniProtKB:Q9JKA3}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Several bitter taste receptors with distinct ligand
CC       specificities are expressed in a single taste receptor cell.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000255}.
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DR   EMBL; AY362735; AAR13344.1; -; Genomic_DNA.
DR   RefSeq; NP_001160162.1; NM_001166690.1.
DR   AlphaFoldDB; Q67ET5; -.
DR   SMR; Q67ET5; -.
DR   STRING; 10116.ENSRNOP00000050711; -.
DR   GlyGen; Q67ET5; 1 site.
DR   PaxDb; Q67ET5; -.
DR   GeneID; 100310886; -.
DR   KEGG; rno:100310886; -.
DR   UCSC; RGD:2314265; rat.
DR   CTD; 667992; -.
DR   RGD; 2314265; Tas2r103.
DR   eggNOG; ENOG502SKRK; Eukaryota.
DR   InParanoid; Q67ET5; -.
DR   PhylomeDB; Q67ET5; -.
DR   PRO; PR:Q67ET5; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0033038; F:bitter taste receptor activity; ISO:RGD.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008527; F:taste receptor activity; ISO:RGD.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:RGD.
DR   InterPro; IPR007960; TAS2R.
DR   Pfam; PF05296; TAS2R; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..312
FT                   /note="Taste receptor type 2 member 103"
FT                   /id="PRO_0000247659"
FT   TOPO_DOM        1..16
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        17..37
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        38..65
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        66..86
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        87..92
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        93..113
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        114..133
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        155..184
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        185..205
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        206..229
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        230..250
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        251..264
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        265..285
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        286..312
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        170
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   312 AA;  34961 MW;  2945D09CFAE68D1A CRC64;
     MVVTMRAALR LMLISTVSLE LIIGILANVF IALVNIIDWI KRGKISAVDK IYMGLAISRT
     AFVLSVITGF LIAFLDPASL GIGIMIRLLT MSWTVTNHFS VWFATCLSIF YFLKITNFSN
     TVFLALKWKV KKVVSVTLVV SLIILFINVI VIHIYTDRFQ VNMVQKCGAN NTLRAYGLFL
     SISTVFTFIP FTASLTMFLL LIFSLWRHLK TMHHNATGSR DVSTVAHIKG LQTVVAFLLL
     YTVFAMSLFS QSLSIDAQHT NLLSHFLRCI GVAFPSGHSC ALILGNNKLR QASLSVIFWL
     RCKYKHTENQ GP