TR104_MOUSE
ID TR104_MOUSE Reviewed; 302 AA.
AC Q7M723; A7MAX0;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Taste receptor type 2 member 104;
DE Short=T2R104;
DE Short=mT2R45;
GN Name=Tas2r104 {ECO:0000312|MGI:MGI:2681185};
GN Synonyms=T2r45 {ECO:0000303|PubMed:12679530};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3] {ECO:0000305, ECO:0000312|EMBL:DAA01213.1}
RP IDENTIFICATION.
RX PubMed=12679530; DOI=10.1093/molbev/msg083;
RA Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT "Adaptive diversification of bitter taste receptor genes in mammalian
RT evolution.";
RL Mol. Biol. Evol. 20:805-814(2003).
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000255}.
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DR EMBL; AC140204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC148229; AAI48230.1; -; mRNA.
DR EMBL; BK001074; DAA01213.1; -; Genomic_DNA.
DR CCDS; CCDS20611.1; -.
DR RefSeq; NP_996894.1; NM_207011.1.
DR AlphaFoldDB; Q7M723; -.
DR SMR; Q7M723; -.
DR STRING; 10090.ENSMUSP00000072237; -.
DR GlyGen; Q7M723; 1 site.
DR PaxDb; Q7M723; -.
DR PRIDE; Q7M723; -.
DR DNASU; 387340; -.
DR Ensembl; ENSMUST00000072404; ENSMUSP00000072237; ENSMUSG00000061977.
DR GeneID; 387340; -.
DR KEGG; mmu:387340; -.
DR UCSC; uc009eiy.1; mouse.
DR CTD; 387340; -.
DR MGI; MGI:2681185; Tas2r104.
DR VEuPathDB; HostDB:ENSMUSG00000061977; -.
DR eggNOG; ENOG502T3AX; Eukaryota.
DR GeneTree; ENSGT00960000186648; -.
DR HOGENOM; CLU_072337_3_0_1; -.
DR InParanoid; Q7M723; -.
DR OMA; IANYSHC; -.
DR OrthoDB; 1010573at2759; -.
DR PhylomeDB; Q7M723; -.
DR TreeFam; TF335891; -.
DR BioGRID-ORCS; 387340; 3 hits in 72 CRISPR screens.
DR PRO; PR:Q7M723; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q7M723; protein.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..302
FT /note="Taste receptor type 2 member 104"
FT /id="PRO_0000248248"
FT TOPO_DOM 1..7
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..43
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..87
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..128
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..182
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 183..203
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 204..229
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 230..250
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 251..259
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..302
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 161
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 302 AA; 34855 MW; D1A5BA3C8350E087 CRC64;
MLSALESILL SVATSEAMLG VLGNTFIVLV NYTDWVRNKK LSKINFILTG LAISRIFTIW
IITLDAYTKV FLLTMLMPSS LHECMSYIWV IINHLSVWFS TSLGIFYFLK IANFSHYIFL
WMKRRADKVF VFLIVFLIIT WLASFPLAVK VIKDVKIYQS NTSWLIHLEK SELLINYVFA
NMGPISLFIV AIIACFLLTI SLWRHSRQMQ SIGSGFRDLN TEAHMKAMKV LIAFIILFIL
YFLGILIETL CLFLTNNKLL FIFGFTLSAM YPCCHSFILI LTSRELKQAT MRALQRLKCC
ET
