ID   TR104_RAT               Reviewed;         302 AA.
AC   Q67ES9;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Taste receptor type 2 member 104;
DE            Short=T2R104;
DE   AltName: Full=Taste receptor type 2 member 21;
DE            Short=T2R21;
GN   Name=Tas2r104 {ECO:0000250|UniProtKB:Q7M723}; Synonyms=Tas2r21;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:AAR13350.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAR13350.1};
RA   Conte C., Ebeling M., Marcuz A., Andres-Barquin P.J.;
RT   "Identification of new putative rat taste receptors belonging to the T2R
RT   family.";
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative taste receptor which may play a role in the
CC       perception of bitterness. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC       taste receptor cell. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000255}.
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DR   EMBL; AY362741; AAR13350.1; -; Genomic_DNA.
DR   RefSeq; NP_001160153.1; NM_001166681.1.
DR   AlphaFoldDB; Q67ES9; -.
DR   SMR; Q67ES9; -.
DR   STRING; 10116.ENSRNOP00000040435; -.
DR   GlyGen; Q67ES9; 2 sites.
DR   PaxDb; Q67ES9; -.
DR   Ensembl; ENSRNOT00000048210; ENSRNOP00000040435; ENSRNOG00000032448.
DR   GeneID; 100310879; -.
DR   KEGG; rno:100310879; -.
DR   UCSC; RGD:2314259; rat.
DR   CTD; 387340; -.
DR   RGD; 2314259; Tas2r104.
DR   eggNOG; ENOG502T3AX; Eukaryota.
DR   GeneTree; ENSGT00960000186648; -.
DR   HOGENOM; CLU_072337_3_0_1; -.
DR   InParanoid; Q67ES9; -.
DR   OMA; IANYSHC; -.
DR   OrthoDB; 1010573at2759; -.
DR   PhylomeDB; Q67ES9; -.
DR   TreeFam; TF335891; -.
DR   PRO; PR:Q67ES9; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IBA:GO_Central.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR007960; TAS2R.
DR   Pfam; PF05296; TAS2R; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..302
FT                   /note="Taste receptor type 2 member 104"
FT                   /id="PRO_0000248249"
FT   TOPO_DOM        1..7
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        8..28
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        29..43
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        44..64
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        65..87
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        88..108
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        109..128
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        150..182
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        183..203
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        204..233
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        234..254
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        255..257
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        279..302
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        160
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        161
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   302 AA;  35103 MW;  77DDDA8E2123C9E2 CRC64;
     MLSMLESILL SVATSEAMLG ILGNIFIVLV NCTNWVRNKK LSKINFILTG LAISRVFTIW
     IITLDAYTKV FFLTTLMPSN LHECISYIWV IINHLSVWFA TSLSIFYFLK IANFSHYIFL
     WLKRRADKVF VFLIGYLIIT WLASFPLAVT VIKNIKVHHN NTSWLIQLEK RELLINYVFA
     NMGPISLFMV AVFTCFLLTI SLWRHRRRMQ STGSKFRDLN TEVHVKAMKV LISFIILFIL
     YFMGVLIETL CLFLTENILL FIFGFTLSST YPCCHSFILI LTSRELKQAS MRALQRLKCC
     ET