TR105_MOUSE
ID TR105_MOUSE Reviewed; 300 AA.
AC Q9JKT4;
DT 11-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Taste receptor type 2 member 105;
DE Short=T2R105;
DE AltName: Full=Taste receptor type 2 member 5;
DE Short=T2R5;
DE AltName: Full=Taste receptor type 2 member 9;
DE Short=T2R9;
GN Name=Tas2r105; Synonyms=Tas2r5, Tas2r9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TOPOLOGY.
RC STRAIN=129/SvJ;
RX PubMed=10761934; DOI=10.1016/s0092-8674(00)80705-9;
RA Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P.,
RA Zuker C.S.;
RT "A novel family of mammalian taste receptors.";
RL Cell 100:693-702(2000).
RN [2]
RP FUNCTION, VARIANTS ILE-44; ASP-155 AND ARG-294, AND POLYMORPHISM.
RX PubMed=10761935; DOI=10.1016/s0092-8674(00)80706-0;
RA Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W.,
RA Zuker C.S., Ryba N.J.P.;
RT "T2Rs function as bitter taste receptors.";
RL Cell 100:703-711(2000).
RN [3]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=15759003; DOI=10.1038/nature03352;
RA Mueller K.L., Hoon M.A., Erlenbach I., Chandrashekar J., Zuker C.S.,
RA Ryba N.J.;
RT "The receptors and coding logic for bitter taste.";
RL Nature 434:225-229(2005).
RN [4]
RP REVIEW.
RX PubMed=12139982; DOI=10.1016/s0959-4388(02)00345-8;
RA Montmayeur J.-P., Matsunami H.;
RT "Receptors for bitter and sweet taste.";
RL Curr. Opin. Neurobiol. 12:366-371(2002).
RN [5]
RP REVIEW.
RX PubMed=11696554; DOI=10.1074/jbc.r100054200;
RA Margolskee R.F.;
RT "Molecular mechanisms of bitter and sweet taste transduction.";
RL J. Biol. Chem. 277:1-4(2002).
RN [6]
RP REVIEW.
RX PubMed=12581520; DOI=10.1016/s0092-8674(03)00071-0;
RA Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D.,
RA Zuker C.S., Ryba N.J.;
RT "Coding of sweet, bitter, and umami tastes: different receptor cells
RT sharing similar signaling pathways.";
RL Cell 112:293-301(2003).
CC -!- FUNCTION: Gustducin-coupled cycloheximide receptor implicated in the
CC perception of bitter compounds in the oral cavity and the
CC gastrointestinal tract. Signals through PLCB2 and the calcium-regulated
CC cation channel TRPM5. {ECO:0000269|PubMed:10761935,
CC ECO:0000269|PubMed:15759003}.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the
CC tongue and palate epithelium and exclusively in gustducin-positive
CC cells. Expressed in gastric and duodenal tissues.
CC -!- POLYMORPHISM: Variations in Tas2r105 are associated with avoidance of
CC cycloheximide at low concentrations. {ECO:0000269|PubMed:10761935}.
CC -!- DISRUPTION PHENOTYPE: Mice fail to avoid cycloheximide at low
CC concentrations and show a lack of cycloheximide-induced action
CC potentials in a principal nerve innervating taste receptor cells of the
CC tongue. {ECO:0000269|PubMed:15759003}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000305}.
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DR EMBL; AF227147; AAF43920.1; -; Genomic_DNA.
DR CCDS; CCDS20612.1; -.
DR RefSeq; NP_065247.1; NM_020501.1.
DR AlphaFoldDB; Q9JKT4; -.
DR SMR; Q9JKT4; -.
DR STRING; 10090.ENSMUSP00000058006; -.
DR ChEMBL; CHEMBL3714703; -.
DR GlyGen; Q9JKT4; 1 site.
DR PaxDb; Q9JKT4; -.
DR PRIDE; Q9JKT4; -.
DR DNASU; 57252; -.
DR Ensembl; ENSMUST00000053652; ENSMUSP00000058006; ENSMUSG00000051153.
DR GeneID; 57252; -.
DR KEGG; mmu:57252; -.
DR UCSC; uc009eiz.1; mouse.
DR CTD; 57252; -.
DR MGI; MGI:2681195; Tas2r105.
DR VEuPathDB; HostDB:ENSMUSG00000051153; -.
DR eggNOG; ENOG502T3AX; Eukaryota.
DR GeneTree; ENSGT00960000186648; -.
DR HOGENOM; CLU_072337_3_0_1; -.
DR InParanoid; Q9JKT4; -.
DR OMA; SRIFIVW; -.
DR OrthoDB; 1010573at2759; -.
DR PhylomeDB; Q9JKT4; -.
DR TreeFam; TF335891; -.
DR BioGRID-ORCS; 57252; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q9JKT4; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9JKT4; protein.
DR Bgee; ENSMUSG00000051153; Expressed in lumbar dorsal root ganglion and 16 other tissues.
DR ExpressionAtlas; Q9JKT4; differential.
DR Genevisible; Q9JKT4; MM.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0008527; F:taste receptor activity; TAS:UniProtKB.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
DR GO; GO:0050913; P:sensory perception of bitter taste; IMP:MGI.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 1: Evidence at protein level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..300
FT /note="Taste receptor type 2 member 105"
FT /id="PRO_0000082359"
FT TOPO_DOM 1..7
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..43
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 65..87
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 88..108
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 109..128
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 129..149
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 150..181
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 182..202
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 203..233
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..259
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 260..280
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 281..300
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 161
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 44
FT /note="T -> I (in strain: BALB/c, C3H/He, CBA/Ca and DBA/
FT 2J)"
FT /evidence="ECO:0000269|PubMed:10761935"
FT VARIANT 155
FT /note="G -> D (in strain: BALB/c, C3H/He, CBA/Ca and DBA/
FT 2J)"
FT /evidence="ECO:0000269|PubMed:10761935"
FT VARIANT 294
FT /note="L -> R (in strain: BALB/c, C3H/He, CBA/Ca and DBA/
FT 2J)"
FT /evidence="ECO:0000269|PubMed:10761935"
SQ SEQUENCE 300 AA; 34416 MW; 92AD449C68FB85EB CRC64;
MLSAAEGILL SIATVEAGLG VLGNTFIALV NCMDWAKNNK LSMTGFLLIG LATSRIFIVW
LLTLDAYAKL FYPSKYFSSS LIEIISYIWM TVNHLTVWFA TSLSIFYFLK IANFSDCVFL
WLKRRTDKAF VFLLGCLLTS WVISFSFVVK VMKDGKVNHR NRTSEMYWEK RQFTINYVFL
NIGVISLFMM TLTACFLLIM SLWRHSRQMQ SGVSGFRDLN TEAHVKAIKF LISFIILFVL
YFIGVSIEII CIFIPENKLL FIFGFTTASI YPCCHSFILI LSNSQLKQAF VKVLQGLKFF
