TR106_MOUSE
ID TR106_MOUSE Reviewed; 308 AA.
AC Q7M724; Q3B817;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Taste receptor type 2 member 106;
DE Short=T2R106;
DE Short=mT2R44;
GN Name=Tas2r106 {ECO:0000312|EMBL:AAI07181.1};
GN Synonyms=T2r44 {ECO:0000303|PubMed:12679530};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000312|EMBL:AAI07181.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3] {ECO:0000305, ECO:0000312|EMBL:DAA01212.1}
RP IDENTIFICATION.
RX PubMed=12679530; DOI=10.1093/molbev/msg083;
RA Shi P., Zhang J., Yang H., Zhang Y.-P.;
RT "Adaptive diversification of bitter taste receptor genes in mammalian
RT evolution.";
RL Mol. Biol. Evol. 20:805-814(2003).
CC -!- FUNCTION: Putative taste receptor which may play a role in the
CC perception of bitterness. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC taste receptor cell. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000255}.
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DR EMBL; AC140204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC107179; AAI07180.1; -; mRNA.
DR EMBL; BC107180; AAI07181.1; -; mRNA.
DR EMBL; BK001073; DAA01212.1; -; Genomic_DNA.
DR CCDS; CCDS20610.1; -.
DR RefSeq; NP_996899.1; NM_207016.1.
DR AlphaFoldDB; Q7M724; -.
DR SMR; Q7M724; -.
DR STRING; 10090.ENSMUSP00000076043; -.
DR GlyGen; Q7M724; 1 site.
DR iPTMnet; Q7M724; -.
DR PhosphoSitePlus; Q7M724; -.
DR PaxDb; Q7M724; -.
DR PRIDE; Q7M724; -.
DR DNASU; 387341; -.
DR Ensembl; ENSMUST00000076756; ENSMUSP00000076043; ENSMUSG00000057754.
DR GeneID; 387341; -.
DR KEGG; mmu:387341; -.
DR UCSC; uc009eix.1; mouse.
DR CTD; 387341; -.
DR MGI; MGI:2681203; Tas2r106.
DR VEuPathDB; HostDB:ENSMUSG00000057754; -.
DR eggNOG; ENOG502T3AX; Eukaryota.
DR GeneTree; ENSGT00960000186648; -.
DR HOGENOM; CLU_072337_3_0_1; -.
DR InParanoid; Q7M724; -.
DR OMA; SHYIFFC; -.
DR OrthoDB; 1010573at2759; -.
DR PhylomeDB; Q7M724; -.
DR TreeFam; TF335891; -.
DR Reactome; R-MMU-418594; G alpha (i) signalling events.
DR Reactome; R-MMU-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR Reactome; R-MMU-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR BioGRID-ORCS; 387341; 0 hits in 70 CRISPR screens.
DR PRO; PR:Q7M724; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q7M724; protein.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0033038; F:bitter taste receptor activity; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:MGI.
DR InterPro; IPR007960; TAS2R.
DR Pfam; PF05296; TAS2R; 1.
PE 2: Evidence at transcript level;
KW G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..308
FT /note="Taste receptor type 2 member 106"
FT /id="PRO_0000248250"
FT TOPO_DOM 1..7
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 8..28
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 29..41
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 42..62
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..78
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 79..99
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 100..124
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 125..145
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..179
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 180..200
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 201..227
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 249..257
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 258..278
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 279..308
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 308 AA; 35498 MW; B6F978425DB8AFDE CRC64;
MLTVAEGILL CFVTSGSVLG VLGNGFILHA NYINCVRKKF STAGFILTGL AICRIFVICI
IISDGYLKLF SPHMVASDAH IIVISYIWVI INHTSIWFAT SLNLFYLLKI ANFSHYIFFC
LKRRINTVFI FLLGCLFISW SIAFPQTVKI FNVKKQHRNV SWQVYLYKNE FIVSHILLNL
GVIFFFMVAI ITCFLLIISL WKHNRKMQLY ASRFKSLNTE VHVKVMKVLI SFIILLILHF
IGILIETLSF LKYENKLLLI LGLIISCMYP CCHSFILILA NSQLKQASLK ALKQLKCHKK
DKDVRVTW
