ID   TR106_RAT               Reviewed;         307 AA.
AC   Q67ET1;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Taste receptor type 2 member 106;
DE            Short=T2R106;
DE   AltName: Full=Taste receptor type 2 member 19;
DE            Short=T2R19;
GN   Name=Tas2r106 {ECO:0000250|UniProtKB:Q7M724}; Synonyms=Tas2r19;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:AAR13348.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAR13348.1};
RA   Conte C., Ebeling M., Marcuz A., Andres-Barquin P.J.;
RT   "Identification of new putative rat taste receptors belonging to the T2R
RT   family.";
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative taste receptor which may play a role in the
CC       perception of bitterness. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Several bitter taste receptors are expressed in a single
CC       taste receptor cell. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC       {ECO:0000255}.
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DR   EMBL; AY362739; AAR13348.1; -; Genomic_DNA.
DR   RefSeq; NP_001160152.1; NM_001166680.1.
DR   AlphaFoldDB; Q67ET1; -.
DR   SMR; Q67ET1; -.
DR   STRING; 10116.ENSRNOP00000051235; -.
DR   GlyGen; Q67ET1; 1 site.
DR   PaxDb; Q67ET1; -.
DR   PRIDE; Q67ET1; -.
DR   Ensembl; ENSRNOT00000044029; ENSRNOP00000051235; ENSRNOG00000031185.
DR   GeneID; 100310878; -.
DR   KEGG; rno:100310878; -.
DR   UCSC; RGD:2314260; rat.
DR   CTD; 387341; -.
DR   RGD; 2314260; Tas2r106.
DR   eggNOG; ENOG502T3AX; Eukaryota.
DR   GeneTree; ENSGT00960000186648; -.
DR   HOGENOM; CLU_072337_3_0_1; -.
DR   InParanoid; Q67ET1; -.
DR   OMA; SHYIFFC; -.
DR   OrthoDB; 1010573at2759; -.
DR   PhylomeDB; Q67ET1; -.
DR   TreeFam; TF335891; -.
DR   Reactome; R-RNO-418594; G alpha (i) signalling events.
DR   Reactome; R-RNO-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
DR   Reactome; R-RNO-9717207; Sensory perception of sweet, bitter, and umami (glutamate) taste.
DR   PRO; PR:Q67ET1; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0033038; F:bitter taste receptor activity; ISO:RGD.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; ISO:RGD.
DR   InterPro; IPR007960; TAS2R.
DR   Pfam; PF05296; TAS2R; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Sensory transduction; Taste; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..307
FT                   /note="Taste receptor type 2 member 106"
FT                   /id="PRO_0000248251"
FT   TOPO_DOM        1..7
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        8..28
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        29..41
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        63..81
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..104
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        105..124
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        125..145
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        146..179
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        201..227
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        249..257
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        258..278
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        279..307
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        159
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   307 AA;  35326 MW;  79CCF7D3DB1BD695 CRC64;
     MLTIPEGILL CFITSGSVLG VLGNGFILHV NCTDCVRQKF STTGFIFTGL AISRICVICI
     IISDGYLKLF SPHMVASDAH IIGISYLWII TNHTSTCFAT ILNLFYFLKI ANFSHYIFFC
     LKRKLNTIFI FLLGCLFISW SVAFPQTVKI FNDKMKHRNT SWKFHLHKSK FIINHILLNL
     GVIFFCMVAI ITSFLLIISL WKHNRKMQLY VSRFKSLNTE VHLKVMKVLI SFIILLILHV
     IGILIETLSF LRYENKLLLI LGLNFSSMYP CCHSFILILA NNQLKQASLK ALKQFKCHKK
     DKDVRET